Evaluation of machine learning algorithms and structural features for optimal MRI-based diagnostic prediction in psychosis

A relatively large number of studies have investigated the power of structural magnetic resonance imaging (sMRI) data to discriminate patients with schizophrenia from healthy controls. However, very few of them have also included patients with bipolar disorder, allowing the clinically relevant discrimination between both psychotic diagnostics. To assess the efficacy of sMRI data for diagnostic prediction in psychosis we objectively evaluated the discriminative power of a wide range of commonly used machine learning algorithms (ridge, lasso, elastic net and L0 norm regularized logistic regressions, a support vector classifier, regularized discriminant analysis, random forests and a Gaussian process classifier) on main sMRI features including grey and white matter voxel-based morphometry (VBM), vertex-based cortical thickness and volume, region of interest volumetric measures and wavelet-based morphometry (WBM) maps. All possible combinations of algorithms and data features were considered in pairwise classifications of matched samples of healthy controls (N = 127), patients with schizophrenia (N = 128) and patients with bipolar disorder (N = 128). Results show that the selection of feature type is important, with grey matter VBM (without data reduction) delivering the best diagnostic prediction rates (averaging over classifiers: schizophrenia vs. healthy 75%, bipolar disorder vs. healthy 63% and schizophrenia vs. bipolar disorder 62%) whereas algorithms usually yielded very similar results. Indeed, those grey matter VBM accuracy rates were not even improved by combining all feature types in a single prediction model. Further multi-class classifications considering the three groups simultaneously made evident a lack of predictive power for the bipolar group, probably due to its intermediate anatomical features, located between those observed in healthy controls and those found in patients with schizophrenia. Finally, we provide MRIPredict (https://www.nitrc.org/projects/mripredict/), a free tool for SPM, FSL and R, to easily carry out voxelwise predictions based on VBM images

CFLCA: High Performance based Heart disease Prediction System using Fuzzy Learning with Neural Networks

Human Diseases are increasing rapidly in today’s generation mainly due to the life style of people like poor diet, lack of exercises, drugs and alcohol consumption etc. But the most spreading disease that is commonly around 80% of people death direct and indirectly heart disease basis. In future (approximately after 10 years) maximum number of people may expire cause of heart diseases. Due to these reasons, many of researchers providing enormous remedy, data analysis in various proposed technologies for diagnosing heart diseases with plenty of medical data which is related to heart disease. In field of Medicine regularly receives very wide range of medical data in the form of text, image, audio, video, signal pockets, etc. This database contains raw dataset which consist of inconsistent and redundant data. The health care system is no doubt very rich in aspect of storing data but at the same time very poor in fetching knowledge. Data mining (DM) methods can help in extracting a valuable knowledge by applying DM terminologies like clustering, regression, segmentation, classification etc. After the collection of data when the dataset becomes larger and more complex than data mining algorithms and clustering algorithms (D-Tree, Neural Networks, K-means, etc.) are used. To get accuracy and precision values improved with proposed method of Cognitive Fuzzy Learning based Clustering Algorithm (CFLCA) method. CFLCA methodology creates advanced meta indexing for n-dimensional unstructured data. The heart disease dataset used after data enrichment and feature engineering with UCI machine learning algorithm, attain high level accurate and prediction rate. Through this proposed CFLCA algorithm is having high accuracy, precision and recall values of data analysis for heart diseases detection

Using attention methods to predict judicial outcomes

Legal Judgment Prediction is one of the most acclaimed fields for the combined area of NLP, AI, and Law. By legal prediction we mean an intelligent systems capable to predict specific judicial characteristics, such as judicial outcome, a judicial class, predict an specific case. In this research, we have used AI classifiers to predict judicial outcomes in the Brazilian legal system. For this purpose, we developed a text crawler to extract data from the official Brazilian electronic legal systems. These texts formed a dataset of second-degree murder and active corruption cases. We applied different classifiers, such as Support Vector Machines and Neural Networks, to predict judicial outcomes by analyzing textual features from the dataset. Our research showed that Regression Trees, Gated Recurring Units and Hierarchical Attention Networks presented higher metrics for different subsets. As a final goal, we explored the weights of one of the algorithms, the Hierarchical Attention Networks, to find a sample of the most important words used to absolve or convict defendants

Identifying prosodic prominence patterns for English text-to-speech synthesis

This thesis proposes to improve and enrich the expressiveness of English Text-to-Speech (TTS) synthesis by identifying and generating natural patterns of prosodic prominence. In most state-of-the-art TTS systems the prediction from text of prosodic prominence relations between words in an utterance relies on features that very loosely account for the combined effects of syntax, semantics, word informativeness and salience, on prosodic prominence. To improve prosodic prominence prediction we first follow up the classic approach in which prosodic prominence patterns are flattened into binary sequences of pitch accented and pitch unaccented words. We propose and motivate statistic and syntactic dependency based features that are complementary to the most predictive features proposed in previous works on automatic pitch accent prediction and show their utility on both read and spontaneous speech. Different accentuation patterns can be associated to the same sentence. Such variability rises the question on how evaluating pitch accent predictors when more patterns are allowed. We carry out a study on prosodic symbols variability on a speech corpus where different speakers read the same text and propose an information-theoretic definition of optionality of symbolic prosodic events that leads to a novel evaluation metric in which prosodic variability is incorporated as a factor affecting prediction accuracy. We additionally propose a method to take advantage of the optionality of prosodic events in unit-selection speech synthesis. To better account for the tight links between the prosodic prominence of a word and the discourse/sentence context, part of this thesis goes beyond the accent/no-accent dichotomy and is devoted to a novel task, the automatic detection of contrast, where contrast is meant as a (Information Structure’s) relation that ties two words that explicitly contrast with each other. This task is mainly motivated by the fact that contrastive words tend to be prosodically marked with particularly prominent pitch accents. The identification of contrastive word pairs is achieved by combining lexical information, syntactic information (which mainly aims to identify the syntactic parallelism that often activates contrast) and semantic information (mainly drawn from the Word- Net semantic lexicon), within a Support Vector Machines classifier. Once we have identified patterns of prosodic prominence we propose methods to incorporate such information in TTS synthesis and test its impact on synthetic speech naturalness trough some large scale perceptual experiments. The results of these experiments cast some doubts on the utility of a simple accent/no-accent distinction in Hidden Markov Model based speech synthesis while highlight the importance of contrastive accents

Linguistically-Informed Neural Architectures for Lexical, Syntactic and Semantic Tasks in Sanskrit

The primary focus of this thesis is to make Sanskrit manuscripts more accessible to the end-users through natural language technologies. The morphological richness, compounding, free word orderliness, and low-resource nature of Sanskrit pose significant challenges for developing deep learning solutions. We identify four fundamental tasks, which are crucial for developing a robust NLP technology for Sanskrit: word segmentation, dependency parsing, compound type identification, and poetry analysis. The first task, Sanskrit Word Segmentation (SWS), is a fundamental text processing task for any other downstream applications. However, it is challenging due to the sandhi phenomenon that modifies characters at word boundaries. Similarly, the existing dependency parsing approaches struggle with morphologically rich and low-resource languages like Sanskrit. Compound type identification is also challenging for Sanskrit due to the context-sensitive semantic relation between components. All these challenges result in sub-optimal performance in NLP applications like question answering and machine translation. Finally, Sanskrit poetry has not been extensively studied in computational linguistics. While addressing these challenges, this thesis makes various contributions: (1) The thesis proposes linguistically-informed neural architectures for these tasks. (2) We showcase the interpretability and multilingual extension of the proposed systems. (3) Our proposed systems report state-of-the-art performance. (4) Finally, we present a neural toolkit named SanskritShala, a web-based application that provides real-time analysis of input for various NLP tasks. Overall, this thesis contributes to making Sanskrit manuscripts more accessible by developing robust NLP technology and releasing various resources, datasets, and web-based toolkit.Comment: Ph.D. dissertatio

Learning from Audio, Vision and Language Modalities for Affect Recognition Tasks

The world around us as well as our responses to worldly events are multimodal in nature. For intelligent machines to integrate seamlessly into our world, it is imperative that they can process and derive useful information from multimodal signals. Such capabilities can be provided to machines by employing multimodal learning algorithms that consider both the individual characteristics of unimodal signals as well as the complementariness provided by multimodal signals. Based on the number of modalities available during the training and testing phases, learning algorithms can be of three categories: unimodal trained and unimodal tested, multimodal trained and multimodal tested, and multimodal trained and unimodal tested algorithms. This thesis provides three contributions, one for each category and focuses on three modalities that are important for human-human and human-machine communication, namely, audio (paralinguistic speech), vision (facial expressions) and language (linguistic speech) signals. For several applications, either due to hardware limitations or deployment specifications, unimodal trained and tested systems suffice. Our first contribution, for the unimodal trained and unimodal tested category, is an end-to-end deep neural network that uses raw speech signals as input for a computational paralinguistic task, namely, verbal conflict intensity estimation. Our model, which uses a convolutional recurrent architecture equipped with attention mechanism to focus on task-relevant instances of the input speech signal, eliminates the need for task-specific meta data or domain knowledge based manual refinement of hand-crafted generic features. The second contribution, for the multimodal trained and multimodal tested category, is a multimodal fusion framework that exploits both cross (inter) and intra-modal interactions for categorical emotion recognition from audiovisual clips. We explore the effectiveness of two types of attention mechanisms, namely, intra and cross-modal attention by creating two versions of our fusion framework. In many applications, multimodal signals might be available during model training phase, yet we cannot expect the availability of all modality signals during testing phase. Our third contribution addresses this situation wherein we propose a framework for cross-modal learning where paired audio-visual instances are used during training to develop test-time stand-alone unimodal models