234 research outputs found
Gaining Insight into Determinants of Physical Activity using Bayesian Network Learning
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228326pub.pdf (publisher's version ) (Open Access)BNAIC/BeneLearn 202
Semantic discovery and reuse of business process patterns
Patterns currently play an important role in modern information systems (IS) development and their use has mainly been restricted to the design and implementation phases of the development lifecycle. Given the increasing significance of business modelling in IS development, patterns have the potential of providing a viable solution for promoting reusability of recurrent generalized models in the very early stages of development. As a statement of research-in-progress this paper focuses on business process patterns and proposes an initial methodological framework for the discovery and reuse of business process patterns within the IS development lifecycle. The framework borrows ideas from the domain engineering literature and proposes the use of semantics to drive both the discovery of patterns as well as their reuse
AI of Brain and Cognitive Sciences: From the Perspective of First Principles
Nowadays, we have witnessed the great success of AI in various applications,
including image classification, game playing, protein structure analysis,
language translation, and content generation. Despite these powerful
applications, there are still many tasks in our daily life that are rather
simple to humans but pose great challenges to AI. These include image and
language understanding, few-shot learning, abstract concepts, and low-energy
cost computing. Thus, learning from the brain is still a promising way that can
shed light on the development of next-generation AI. The brain is arguably the
only known intelligent machine in the universe, which is the product of
evolution for animals surviving in the natural environment. At the behavior
level, psychology and cognitive sciences have demonstrated that human and
animal brains can execute very intelligent high-level cognitive functions. At
the structure level, cognitive and computational neurosciences have unveiled
that the brain has extremely complicated but elegant network forms to support
its functions. Over years, people are gathering knowledge about the structure
and functions of the brain, and this process is accelerating recently along
with the initiation of giant brain projects worldwide. Here, we argue that the
general principles of brain functions are the most valuable things to inspire
the development of AI. These general principles are the standard rules of the
brain extracting, representing, manipulating, and retrieving information, and
here we call them the first principles of the brain. This paper collects six
such first principles. They are attractor network, criticality, random network,
sparse coding, relational memory, and perceptual learning. On each topic, we
review its biological background, fundamental property, potential application
to AI, and future development.Comment: 59 pages, 5 figures, review articl
Generative-Discriminative Low Rank Decomposition for Medical Imaging Applications
In this thesis, we propose a method that can be used to extract biomarkers from medical images toward early diagnosis of abnormalities. Surge of demand for biomarkers and availability of medical images in the recent years call for accurate, repeatable, and interpretable approaches for extracting meaningful imaging features. However, extracting such information from medical images is a challenging task because the number of pixels (voxels) in a typical image is in order of millions while even a large sample-size in medical image dataset does not usually exceed a few hundred. Nevertheless, depending on the nature of an abnormality, only a parsimonious subset of voxels is typically relevant to the disease; therefore various notions of sparsity are exploited in this thesis to improve the generalization performance of the prediction task.
We propose a novel discriminative dimensionality reduction method that yields good classification performance on various datasets without compromising the clinical interpretability of the results. This is achieved by combining the modelling strength of generative learning framework and the classification performance of discriminative learning paradigm. Clinical interpretability can be viewed as an additional measure of evaluation and is also helpful in designing methods that account for the clinical prior such as association of certain areas in a brain to a particular cognitive task or connectivity of some brain regions via neural fibres.
We formulate our method as a large-scale optimization problem to solve a constrained matrix factorization. Finding an optimal solution of the large-scale matrix factorization renders off-the-shelf solver computationally prohibitive; therefore, we designed an efficient algorithm based on the proximal method to address the computational bottle-neck of the optimization problem. Our formulation is readily extended for different scenarios such as cases where a large cohort of subjects has uncertain or no class labels (semi-supervised learning) or a case where each subject has a battery of imaging channels (multi-channel), \etc. We show that by using various notions of sparsity as feasible sets of the optimization problem, we can encode different forms of prior knowledge ranging from brain parcellation to brain connectivity
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