Correlation of periodontal pathogens in concurrent endodontic-periodontal diseases

Objectives: This study investigated the correlation between Tannerella forsythia, Porphyromonas gingivalis, Fusobacterium nucleatum, and Aggregatibacter actinomycetemcomitans at dual sites in concurrent endodonticperiodontal diseases. Material and methods: Samples were collected from endodontium and periodontium in cases of concurrent endodontic-periodontal diseases from thirty participants. The sensitivity and specificity of SYBR Green real-time PCR was used to identify the targeted species. Absolute number of targeted genome copies in tested samples were extrapolated from respective calibration curve. Results: No statistical difference was found in the number of detected endodontic-periodontal pathogens between the endodontium and periodontium. The Pearson test detected significant correlation (P\u3c0.001) between targeted bacteria; T. forsythia, F. nucleatum, and P. gingivalis from endodontic-periodontal lesions. Synergistic component observed separately in endodontic biofilm was found only between T. forsythia and F. nucleatum (r=0.380, P=0.03) while in periodontal biofilm T. forsythia, F. nucleatum and P. gingivalis gave high synergism result (P\u3c0.0001). Correlation analysis showed that T. forsythia in primary endodontic infection and in periodontal lesion was significantly decreased with the increase of patients age (r=-0.308, P=0.017). Conclusions: Correlation between targeted bacterial species levels from concurrent endodonticperiodontal diseases confirmed that coronal and cervical dentinal tubules may represent a viable pathway that allows spreading and maintaining of dual sites infection. Periodontal bacteria detected in root canal of concurrent endodontic-periodontal infections may originate from the local periodontal lesions

Intellectual property rights and agro-based natural product: Malaysian legal perspective

Malaysia is a country which has been blessed with plethora of natural resources and product such as plants and animals. It is an established fact that the agriculture sector part of our natural product contributed substantially to the growth and development of the Malaysian economy. At the same time, it falls as part of the property which must be protected to ensure its sustainability. This paper will look into the right and protection of agro-based natural product specifically to the plant varieties and geographical indications from Intellectual Property Rights perspective in Malaysia

Macronutrient cycling in surface waters

The levels and relative proportions of macronutrients set the conditions for life in surface waters. Man-made disturbances to macronutrient cycling have caused environmental problems such as eutrophication, acidification and global change. In this thesis, macronutrient cycling was studied by performing spatial and temporal large-scale studies of aquatic, terrestrial and atmospheric national monitoring data. Trophic status was found to have a profound impact on nitrate-nitrogen (NO₃-N) concentrations in surface waters. Lakes and streams of the same trophic status displayed opposite NO₃-N patterns. These findings are of great importance when dealing with environmental assessment on the landscape scale, and an awareness of these patterns may also facilitate the design of sampling programs. Trophic status also seems important for trends in total phosphorus (TP) and total organic carbon (TOC) concentrations in boreal and alpine catchments. A temporal study of TP and TOC concentrations showed decreases in nutrient-poor catchments and increases in more nutrient-rich surface waters. Different responses of terrestrial organic matter production and decomposition to temperature increases may be responsible for the observed patterns. Consequently, continued global warming may lead to a stronger polarization between the nutrient-poor northern and the more nutrient-rich southern catchments. Further studies showed that nutrient conditions in soils and surface waters were strongly affected by atmospheric deposition. By using large data-sets on nutrient content in soils and nutrient concentrations in lakes, it was found that carbon to nitrogen ratios (C:N) in the organic soil layer and in lakes increased from the southern to the northern parts of Sweden, resulting in a strong relationship between soil and lake water C:N. The strong relationship was primarily due to the high correlation between nitrogen (N) in organic soil layer and lake N. Large-scale variations in soil C content were not strongly linked to lake C concentrations whereas soil N seemed to leach in the form of NO₃-N to lakes. By calculating catchment soil, lake and river mouth C stocks, it was estimated that about 10 % of Sweden's total terrestrial net ecosystem production is transported through lakes annually. This indicates that the amount of C exported from soils is substantial and that boreal soils maybe less important as a C sink as previously thought. Furthermore, it was found that the colored portion of C was selectively lost and that the decrease in water color was dependent on water retention time. This implies that under conditions predicted in future climate scenarios of increased precipitation, water reaching the seas will be more colored than today. The results from this thesis highlight the importance of atmospheric N deposition and trophic status to macronutrient cycling in both terrestrial and aquatic ecosystems

A predictive processing theory of sensorimotor contingencies: explaining the puzzle of perceptual presence and its absence in synesthesia

Normal perception involves experiencing objects within perceptual scenes as real, as existing in the world. This property of “perceptual presence” has motivated “sensorimotor theories” which understand perception to involve the mastery of sensorimotor contingencies. However, the mechanistic basis of sensorimotor contingencies and their mastery has remained unclear. Sensorimotor theory also struggles to explain instances of perception, such as synesthesia, that appear to lack perceptual presence and for which relevant sensorimotor contingencies are difficult to identify. On alternative “predictive processing” theories, perceptual content emerges from probabilistic inference on the external causes of sensory signals, however, this view has addressed neither the problem of perceptual presence nor synesthesia. Here, I describe a theory of predictive perception of sensorimotor contingencies which (1) accounts for perceptual presence in normal perception, as well as its absence in synesthesia, and (2) operationalizes the notion of sensorimotor contingencies and their mastery. The core idea is that generative models underlying perception incorporate explicitly counterfactual elements related to how sensory inputs would change on the basis of a broad repertoire of possible actions, even if those actions are not performed. These “counterfactually-rich” generative models encode sensorimotor contingencies related to repertoires of sensorimotor dependencies, with counterfactual richness determining the degree of perceptual presence associated with a stimulus. While the generative models underlying normal perception are typically counterfactually rich (reflecting a large repertoire of possible sensorimotor dependencies), those underlying synesthetic concurrents are hypothesized to be counterfactually poor. In addition to accounting for the phenomenology of synesthesia, the theory naturally accommodates phenomenological differences between a range of experiential states including dreaming, hallucination, and the like. It may also lead to a new view of the (in)determinacy of normal perception

Parameterized Concurrent Multi-Party Session Types

Session types have been proposed as a means of statically verifying implementations of communication protocols. Although prior work has been successful in verifying some classes of protocols, it does not cope well with parameterized, multi-actor scenarios with inherent asynchrony. For example, the sliding window protocol is inexpressible in previously proposed session type systems. This paper describes System-A, a new typing language which overcomes many of the expressiveness limitations of prior work. System-A explicitly supports asynchrony and parallelism, as well as multiple forms of parameterization. We define System-A and show how it can be used for the static verification of a large class of asynchronous communication protocols.Comment: In Proceedings FOCLASA 2012, arXiv:1208.432

Structure and shaping processes within the extended atmospheres of AGB stars

We present recent studies using the near-infrared instrument AMBER of the VLT Interferometer (VLTI) to investigate the structure and shaping processes within the extended atmosphere of AGB stars. Spectrally resolved near-infrared AMBER observations of the Mira variable S Ori have revealed wavelength-dependent apparent angular sizes. These data were successfully compared to dynamic model atmospheres, which predict wavelength-dependent radii because of geometrically extended molecular layers. Most recently, AMBER closure phase measurements of several AGB stars have also revealed wavelength-dependent deviations from 0/180 deg., indicating deviations from point symmetry. The variation of closure phase with wavelength indicates a complex non-spherical stratification of the extended atmosphere, and may reveal whether observed asymmetries are located near the photosphere or in the outer molecular layers. Concurrent observations of SiO masers located within the extended molecular layers provide us with additional information on the morphology, conditions, and kinematics of this shell. These observations promise to provide us with new important insights into the shaping processes at work during the AGB phase. With improved imaging capabilities at the VLTI, we expect to extend the successful story of imaging studies of planetary nebulae to the photosphere and extended outer atmosphere of AGB stars.Comment: 6 pages, Proc. of "Asymmetric Planetary Nebulae V", A.A. Zijlstra, F. Lykou, I. McDonald, and E. Lagadec (eds.), Jodrell Bank Centre for Astrophysics, Manchester, UK, 201

Petri Games: Synthesis of Distributed Systems with Causal Memory

We present a new multiplayer game model for the interaction and the flow of information in a distributed system. The players are tokens on a Petri net. As long as the players move in independent parts of the net, they do not know of each other; when they synchronize at a joint transition, each player gets informed of the causal history of the other player. We show that for Petri games with a single environment player and an arbitrary bounded number of system players, deciding the existence of a safety strategy for the system players is EXPTIME-complete.Comment: In Proceedings GandALF 2014, arXiv:1408.556

Design Environments for Complex Systems

The paper describes an approach for modeling complex systems by hiding as much formal details as possible from the user, still allowing verification and simulation of the model. The interface is based on UML to make the environment available to the largest audience. To carry out analysis, verification and simulation we automatically extract process algebras specifications from UML models. The results of the analysis is then reflected back in the UML model by annotating diagrams. The formal model includes stochastic information to handle quantitative parameters. We present here the stochastic -calculus and we discuss the implementation of its probabilistic support that allows simulation of processes. We exploit the benefits of our approach in two applicative domains: global computing and systems biology