Performance analysis of feedback-free collision resolution NDMA protocol

To support communications of a large number of deployed devices while guaranteeing limited signaling load, low energy consumption, and high reliability, future cellular systems require efficient random access protocols. However, how to address the collision resolution at the receiver is still the main bottleneck of these protocols. The network-assisted diversity multiple access (NDMA) protocol solves the issue and attains the highest potential throughput at the cost of keeping devices active to acquire feedback and repeating transmissions until successful decoding. In contrast, another potential approach is the feedback-free NDMA (FF-NDMA) protocol, in which devices do repeat packets in a pre-defined number of consecutive time slots without waiting for feedback associated with repetitions. Here, we investigate the FF-NDMA protocol from a cellular network perspective in order to elucidate under what circumstances this scheme is more energy efficient than NDMA. We characterize analytically the FF-NDMA protocol along with the multipacket reception model and a finite Markov chain. Analytic expressions for throughput, delay, capture probability, energy, and energy efficiency are derived. Then, clues for system design are established according to the different trade-offs studied. Simulation results show that FF-NDMA is more energy efficient than classical NDMA and HARQ-NDMA at low signal-to-noise ratio (SNR) and at medium SNR when the load increases.Peer ReviewedPostprint (published version

M-health review: joining up healthcare in a wireless world

In recent years, there has been a huge increase in the use of information and communication technologies (ICT) to deliver health and social care. This trend is bound to continue as providers (whether public or private) strive to deliver better care to more people under conditions of severe budgetary constraint

Proceedings of the ECCS 2005 satellite workshop: embracing complexity in design - Paris 17 November 2005

Embracing complexity in design is one of the critical issues and challenges of the 21st century. As the realization grows that design activities and artefacts display properties associated with complex adaptive systems, so grows the need to use complexity concepts and methods to understand these properties and inform the design of better artifacts. It is a great challenge because complexity science represents an epistemological and methodological swift that promises a holistic approach in the understanding and operational support of design. But design is also a major contributor in complexity research. Design science is concerned with problems that are fundamental in the sciences in general and complexity sciences in particular. For instance, design has been perceived and studied as a ubiquitous activity inherent in every human activity, as the art of generating hypotheses, as a type of experiment, or as a creative co-evolutionary process. Design science and its established approaches and practices can be a great source for advancement and innovation in complexity science. These proceedings are the result of a workshop organized as part of the activities of a UK government AHRB/EPSRC funded research cluster called Embracing Complexity in Design (www.complexityanddesign.net) and the European Conference in Complex Systems (complexsystems.lri.fr). Embracing complexity in design is one of the critical issues and challenges of the 21st century. As the realization grows that design activities and artefacts display properties associated with complex adaptive systems, so grows the need to use complexity concepts and methods to understand these properties and inform the design of better artifacts. It is a great challenge because complexity science represents an epistemological and methodological swift that promises a holistic approach in the understanding and operational support of design. But design is also a major contributor in complexity research. Design science is concerned with problems that are fundamental in the sciences in general and complexity sciences in particular. For instance, design has been perceived and studied as a ubiquitous activity inherent in every human activity, as the art of generating hypotheses, as a type of experiment, or as a creative co-evolutionary process. Design science and its established approaches and practices can be a great source for advancement and innovation in complexity science. These proceedings are the result of a workshop organized as part of the activities of a UK government AHRB/EPSRC funded research cluster called Embracing Complexity in Design (www.complexityanddesign.net) and the European Conference in Complex Systems (complexsystems.lri.fr)

The thermodynamics of computational copying in biochemical systems

Living cells use readout molecules to record the state of receptor proteins, similar to measurements or copies in typical computational devices. But is this analogy rigorous? Can cells be optimally efficient, and if not, why? We show that, as in computation, a canonical biochemical readout network generates correlations; extracting no work from these correlations sets a lower bound on dissipation. For general input, the biochemical network cannot reach this bound, even with arbitrarily slow reactions or weak thermodynamic driving. It faces an accuracy-dissipation trade-off that is qualitatively distinct from and worse than implied by the bound, and more complex steady-state copy processes cannot perform better. Nonetheless, the cost remains close to the thermodynamic bound unless accuracy is extremely high. Additionally, we show that biomolecular reactions could be used in thermodynamically optimal devices under exogenous manipulation of chemical fuels, suggesting an experimental system for testing computational thermodynamics.Comment: Accepted versio

Proceedings of the Second International Mobile Satellite Conference (IMSC 1990)

Presented here are the proceedings of the Second International Mobile Satellite Conference (IMSC), held June 17-20, 1990 in Ottawa, Canada. Topics covered include future mobile satellite communications concepts, aeronautical applications, modulation and coding, propagation and experimental systems, mobile terminal equipment, network architecture and control, regulatory and policy considerations, vehicle antennas, and speech compression

Patient-derived iPSCs show premature neural differentiation and neuron type-specific phenotypes relevant to neurodevelopment.

Ras/MAPK pathway signaling is a major participant in neurodevelopment, and evidence suggests that BRAF, a key Ras signal mediator, influences human behavior. We studied the role of the mutation BRAFQ257R, the most common cause of cardiofaciocutaneous syndrome (CFC), in an induced pluripotent stem cell (iPSC)-derived model of human neurodevelopment. In iPSC-derived neuronal cultures from CFC subjects, we observed decreased p-AKT and p-ERK1/2 compared to controls, as well as a depleted neural progenitor pool and rapid neuronal maturation. Pharmacological PI3K/AKT pathway manipulation recapitulated cellular phenotypes in control cells and attenuated them in CFC cells. CFC cultures displayed altered cellular subtype ratios and increased intrinsic excitability. Moreover, in CFC cells, Ras/MAPK pathway activation and morphological abnormalities exhibited cell subtype-specific differences. Our results highlight the importance of exploring specific cellular subtypes and of using iPSC models to reveal relevant human-specific neurodevelopmental events

Kinetic Intersections as a Source of Information on Rate Coefficients

C

Feedback Mechanisms for Centralized and Distributed Mobile Systems

The wireless communication market is expected to witness considerable growth in the immediate future due to increasing smart device usage to access real-time data. Mobile devices become the predominant method of Internet access via cellular networks (4G/5G) and the onset of virtual reality (VR), ushering in the wide deployment of multiple bands, ranging from TVWhite Spaces to cellular/WiFi bands and on to mmWave. Multi-antenna techniques have been considered to be promising approaches in telecommunication to optimize the utilization of radio spectrum and minimize the cost of system construction. The performance of multiple antenna technology depends on the utilization of radio propagation properties and feedback of such information in a timely manner. However, when a signal is transmitted, it is usually dispersed over time coming over different paths of different lengths due to reflections from obstacles or affected by Doppler shift in mobile environments. This motivates the design of novel feedback mechanisms that improve the performance of multi-antenna systems. Accurate channel state information (CSI) is essential to increasing throughput in multiinput, multi-output (MIMO) systems with digital beamforming. Channel-state information for the operation of MIMO schemes (such as transmit diversity or spatial multiplexing) can be acquired by feedback of CSI reports in the downlink direction, or inferred from uplink measurements assuming perfect channel reciprocity (CR). However, most works make the assumption that channels are perfectly reciprocal. This assumption is often incorrect in practice due to poor channel estimation and imperfect channel feedback. Instead, experiments have demonstrated that channel reciprocity can be easily broken by multiple factors. Specifically, channel reciprocity error (CRE) introduced by transmitter-receiver imbalance have been widely studied by both simulations and experiments, and the impact of mobility and estimation error have been fully investigated in this thesis. In particular, unmanned aerial vehicles (UAVs) have asymmetric behavior when communicating with one another and to the ground, due to differences in altitude that frequently occur. Feedback mechanisms are also affected by channel differences caused by the user’s body. While there has been work to specifically quantify the losses in signal reception, there has been little work on how these channel differences affect feedback mechanisms. In this dissertation, we perform system-level simulations, implement design with a software defined radio platform, conduct in-field experiments for various wireless communication systems to analyze different channel feedback mechanisms. To explore the feedback mechanism, we then explore two specific real world scenarios, including UAV-based beamforming communications, and user-induced feedback systems

Functional analysis of High-Throughput data for dynamic modeling in eukaryotic systems

Das Verhalten Biologischer Systeme wird durch eine Vielzahl regulatorischer Prozesse beeinflusst, die sich auf verschiedenen Ebenen abspielen. Die Forschung an diesen Regulationen hat stark von den großen Mengen von Hochdurchsatzdaten profitiert, die in den letzten Jahren verfügbar wurden. Um diese Daten zu interpretieren und neue Erkenntnisse aus ihnen zu gewinnen, hat sich die mathematische Modellierung als hilfreich erwiesen. Allerdings müssen die Daten vor der Integration in Modelle aggregiert und analysiert werden. Wir präsentieren vier Studien auf unterschiedlichen zellulären Ebenen und in verschiedenen Organismen. Zusätzlich beschreiben wir zwei Computerprogramme die den Vergleich zwischen Modell und Experimentellen Daten erleichtern. Wir wenden diese Programme in zwei Studien über die MAP Kinase (MAP, engl. mitogen-acticated-protein) Signalwege in Saccharomyces cerevisiae an, um Modellalternativen zu generieren und unsere Vorstellung des Systems an Daten anzupassen. In den zwei verbleibenden Studien nutzen wir bioinformatische Methoden, um Hochdurchsatz-Zeitreihendaten von Protein und mRNA Expression zu analysieren. Um die Daten interpretieren zu können kombinieren wir sie mit Netzwerken und nutzen Annotationen um Module identifizieren, die ihre Expression im Lauf der Zeit ändern. Im Fall der humanen somatischen Zell Reprogrammierung führte diese Analyse zu einem probabilistischen Boolschen Modell des Systems, welches wir nutzen konnten um neue Hypothesen über seine Funktionsweise aufzustellen. Bei der Infektion von Säugerzellen (Canis familiaris) mit dem Influenza A Virus konnten wir neue Verbindungen zwischen dem Virus und seinem Wirt herausfinden und unsere Zeitreihendaten in bestehende Netzwerke einbinden. Zusammenfassend zeigen viele unserer Ergebnisse die Wichtigkeit von Datenintegration in mathematische Modelle, sowie den hohen Grad der Verschaltung zwischen verschiedenen Regulationssystemen.The behavior of all biological systems is governed by numerous regulatory mechanisms, acting on different levels of time and space. The study of these regulations has greatly benefited from the immense amount of data that has become available from high-throughput experiments in recent years. To interpret this mass of data and gain new knowledge about studied systems, mathematical modeling has proven to be an invaluable method. Nevertheless, before data can be integrated into a model it needs to be aggregated, analyzed, and the most important aspects need to be extracted. We present four Systems Biology studies on different cellular organizational levels and in different organisms. Additionally, we describe two software applications that enable easy comparison of data and model results. We use these in two of our studies on the mitogen-activated-protein (MAP) kinase signaling in Saccharomyces cerevisiae to generate model alternatives and adapt our representation of the system to biological data. In the two remaining studies we apply Bioinformatic methods to analyze two high-throughput time series on proteins and mRNA expression in mammalian cells. We combine the results with network data and use annotations to identify modules and pathways that change in expression over time to be able to interpret the datasets. In case of the human somatic cell reprogramming (SCR) system this analysis leads to the generation of a probabilistic Boolean model which we use to generate new hypotheses about the system. In the last system we examined, the infection of mammalian (Canis familiaris) cells by the influenza A virus, we find new interconnections between host and virus and are able to integrate our data with existing networks. In summary, many of our findings show the importance of data integration into mathematical models and the high degree of connectivity between different levels of regulation

Split and Shift Methodology: Overcoming Hardware Limitations on Cellular Processor Arrays for Image Processing

Na era multimedia, o procesado de imaxe converteuse nun elemento de singular importancia nos dispositivos electrónicos. Dende as comunicacións (p.e. telemedicina), a seguranza (p.e. recoñecemento retiniano) ou control de calidade e de procesos industriais (p.e. orientación de brazos articulados, detección de defectos do produto), pasando pola investigación (p.e. seguimento de partículas elementais) e diagnose médica (p.e. detección de células estrañas, identificaciónn de veas retinianas), hai un sinfín de aplicacións onde o tratamento e interpretación automáticas de imaxe e fundamental. O obxectivo último será o deseño de sistemas de visión con capacidade de decisión. As tendencias actuais requiren, ademais, a combinación destas capacidades en dispositivos pequenos e portátiles con resposta en tempo real. Isto propón novos desafíos tanto no deseño hardware como software para o procesado de imaxe, buscando novas estruturas ou arquitecturas coa menor area e consumo de enerxía posibles sen comprometer a funcionalidade e o rendemento