Research in multi-cultural relationship building

This study aims to explore the ‘missing gap' between the values of an Accounting firm and the preference shown by Maaori on how they would like to be approached when wanting to build a trusted relationship within a business sense. This study makes use of qualitative approaches in which data is collected primarily through interviews and analysed to produce results and recommendations. The study found that Maaori would like to be approached in a way that makes sense to them and also identifies with their cultural proceedings. It also provides insight into how important trust is when establishing a relationship with Maaori. The study recommends that further studies conducted should interview a wider variety of focus groups to add different elements to this research and that FIRM A's small business department's offerings do not align with what Maaori want so need to be rethought to adapt to Maaor expectations

Using Large Language Models to Generate, Validate, and Apply User Intent Taxonomies

Log data can reveal valuable information about how users interact with web search services, what they want, and how satisfied they are. However, analyzing user intents in log data is not easy, especially for new forms of web search such as AI-driven chat. To understand user intents from log data, we need a way to label them with meaningful categories that capture their diversity and dynamics. Existing methods rely on manual or ML-based labeling, which are either expensive or inflexible for large and changing datasets. We propose a novel solution using large language models (LLMs), which can generate rich and relevant concepts, descriptions, and examples for user intents. However, using LLMs to generate a user intent taxonomy and apply it to do log analysis can be problematic for two main reasons: such a taxonomy is not externally validated, and there may be an undesirable feedback loop. To overcome these issues, we propose a new methodology with human experts and assessors to verify the quality of the LLM-generated taxonomy. We also present an end-to-end pipeline that uses an LLM with human-in-the-loop to produce, refine, and use labels for user intent analysis in log data. Our method offers a scalable and adaptable way to analyze user intents in web-scale log data with minimal human effort. We demonstrate its effectiveness by uncovering new insights into user intents from search and chat logs from Bing

Decoding Complexity in Metabolic Networks using Integrated Mechanistic and Machine Learning Approaches

How can we get living cells to do what we want? What do they actually ‘want’? What ‘rules’ do they observe? How can we better understand and manipulate them? Answers to fundamental research questions like these are critical to overcoming bottlenecks in metabolic engineering and optimizing heterologous pathways for synthetic biology applications. Unfortunately, biological systems are too complex to be completely described by physicochemical modeling alone. In this research, I developed and applied integrated mechanistic and data-driven frameworks to help uncover the mysteries of cellular regulation and control. These tools provide a computational framework for seeking answers to pertinent biological questions. Four major tasks were accomplished. First, I developed innovative tools for key areas in the genome-to-phenome mapping pipeline. An efficient gap filling algorithm (called BoostGAPFILL) that integrates mechanistic and machine learning techniques was developed for the refinement of genome-scale metabolic network reconstructions. Genome-scale metabolic network reconstructions are finding ever increasing applications in metabolic engineering for industrial, medical and environmental purposes. Second, I designed a thermodynamics-based framework (called REMEP) for mutant phenotype prediction (integrating metabolomics, fluxomics and thermodynamics data). These tools will go a long way in improving the fidelity of model predictions of microbial cell factories. Third, I designed a data-driven framework for characterizing and predicting the effectiveness of metabolic engineering strategies. This involved building a knowledgebase of historical microbial cell factory performance from published literature. Advanced machine learning concepts, such as ensemble learning and data augmentation, were employed in combination with standard mechanistic models to develop a predictive platform for important industrial biotechnology metrics such as yield, titer, and productivity. Fourth, my modeling tools and skills have been used for case studies on fungal lipid metabolism analyses, E. coli resource allocation balances, reconstruction of the genome-scale metabolic network for a non-model species, R. opacus, as well as the rapid prediction of bacterial heterotrophic fluxomics. In the long run, this integrated modeling approach will significantly shorten the “design-build-test-learn” cycle of metabolic engineering, as well as provide a platform for biological discovery