Laboratory medicine : a national status report

Although the U.S. ranks highest in per capita health care spending, there is overwhelming evidence of gaps between well-founded standards of care and health care practice. The Institute of Medicine reports, To Err is Human: Building a Safer Health System (1999) and Crossing the Quality Chasm: A New Health System for the 21st Century (2001), and other sentinel studies have focused national attention on improving the quality and safety of health care. Stakeholders agree that the quality of care delivered in the U.S. is inadequate and that the organization and delivery of health care must be improved.Given the shortfalls in quality and continued escalation in costs, health care must be assessed continually to inform decision-making, and redesign delivery and incentives as needed, to yield appropriate, high quality care. An integral component of care is laboratory medicine, which extends across research; screening, diagnosis, and treatment; and public health. Appropriate use of laboratory testing is essential for achieving safe, effective, and efficient care to patients.Health care must be informed by data derived from scientific assessment of efficacy and effectiveness of procedures, and must adapt to ongoing changes in science, technology, and practice. Laboratory medicine is not only responding to these changes, but is contributing to them in an environment of demographic, social, and economic change.The Centers for Disease Control and Prevention (CDC) has commissioned this report to contribute to the groundwork for transforming laboratory medicine over the next decade. CDC charged The Lewin Group, under subcontract to Battelle Memorial Institute, with drafting this document, Laboratory Medicine: A National Status Report. The report examines in detail the key factors affecting the laboratory medicine sector, and is organized into chapters on the following main topics:Value of laboratory medicine\ue2\u20ac\ua2 Market profile of the laboratory medicine sector\ue2\u20ac\ua2 Laboratory medicine workforce\ue2\u20ac\ua2 Quality and the total testing process\ue2\u20ac\ua2 Quality systems and performance measurement\ue2\u20ac\ua2 Laboratory information systems\ue2\u20ac\ua2 Federal regulatory oversight of laboratory medicine\ue2\u20ac\ua2 Reimbursement for laboratory medicinePrepared for: Division of Laboratory Systems, National Center for Preparedness, Detection, and Control of Infectious Diseases, Centers for Disease Control and Prevention; prepared by: The Lewin Group under subcontract to Battelle Memorial Institute.Acknowledgments -- Executive summary -- Introduction -- Methods and limitations -- I. The value of laboratory medicine to health care -- II. Market profile of the laboratory medicine sector -- III. Laboratory medicine workforce -- IV. Quality and the total testing process -- V. Quality systems and performance measurement -- VI. Laboratory information systems -- VII. Federal regulatory oversight of laboratory medicine -- VIII. Reimbursement for laboratory medicine -- Appendix A. Desirable characteristics for performance measures -- Appendix B. Summary of selected performance indicators used by stakeholders -- Appendix C. Development of the Medicare payment system

ABSTRACT BOOK 50th World Conference on Lung Health of the International Union Against Tuberculosis and Lung Disease (The Union)

The International Journal of Tuberculosis and Lung Disease is an official journal of The Union. The Journal’s main aim is the continuing education of physicians and other health personnel, and the dissemination of the most up-to-date infor mation in the field of tuberculosis and lung health. It publishes original articles and commissioned reviews not only on the clinical and biological and epidemiological aspects, but also—and more importantly—on community aspects: fundamental research and the elaboration, implementation and assessment of field projects and action programmes for tuberculosis control and the promo tion of lung health. The Journal welcomes articles submitted on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research

Boise State University Undergraduate Catalog: 1995-1996

https://scholarship.shu.edu/undergraduate_catalogues/1046/thumbnail.jp

General catalog, 1990-92

Course catalogs were published under the following titles: Catalogue of the officers and students of the Kansas State Agricultural College, with a brief history of the institution, 1st (1863/4); Annual catalogue of the officers and students of the Kansas State Agricultural College for, 2nd (1864/5)-4th (1868/9); Catalogue of the officers and students of the Kansas State Agricultural College for the year, 1869-1871/2; Hand-book of the Kansas State Agricultural College, Manhattan, Kansas, 1873/4; Biennial catalogue of the Kansas State Agricultural College, Manhattan, Kansas, calendar years, 1875/77; Catalogue of the State Agricultural College of Kansas, 1877/80-1896/97; Annual catalogue of the officers, students and graduates of the Kansas State Agricultural College, Manhattan, 35th (1897/98)-46th (1908/09); Catalogue, 47th (1909/10)-67th (1929/30); Complete catalogue number, 68th (1930/31)-81st (1943/1944); Catalogue, 1945/1946-1948/1949?; General catalogue, 1949/1950?-1958/1960; General catalog, 1960/1962-1990/1992. Course catalogs then split into undergraduate and graduate catalogs respectively: K-State undergraduate catalog, 1992/1994- ; K-State graduate catalog, 1993/1995-Citation: Kansas State University. (1990). General catalog, 1990-92. Manhattan, KS: Kansas State University.Call number: LD2668 .A24

Frameshift mutations at the C-terminus of HIST1H1E result in a specific DNA hypomethylation signature

BACKGROUND: We previously associated HIST1H1E mutations causing Rahman syndrome with a specific genome-wide methylation pattern. RESULTS: Methylome analysis from peripheral blood samples of six affected subjects led us to identify a specific hypomethylated profile. This "episignature" was enriched for genes involved in neuronal system development and function. A computational classifier yielded full sensitivity and specificity in detecting subjects with Rahman syndrome. Applying this model to a cohort of undiagnosed probands allowed us to reach diagnosis in one subject. CONCLUSIONS: We demonstrate an epigenetic signature in subjects with Rahman syndrome that can be used to reach molecular diagnosis

Aerospace Medicine and Biology - A continuing bibliography with indexes

Annotated bibliography and indexes on Aerospace Medicine and Biology - Dec. 196

Assuming Data Integrity and Empirical Evidence to The Contrary

Background: Not all respondents to surveys apply their minds or understand the posed questions, and as such provide answers which lack coherence, and this threatens the integrity of the research. Casual inspection and limited research of the 10-item Big Five Inventory (BFI-10), included in the dataset of the World Values Survey (WVS), suggested that random responses may be common. Objective: To specify the percentage of cases in the BRI-10 which include incoherent or contradictory responses and to test the extent to which the removal of these cases will improve the quality of the dataset. Method: The WVS data on the BFI-10, measuring the Big Five Personality (B5P), in South Africa (N=3 531), was used. Incoherent or contradictory responses were removed. Then the cases from the cleaned-up dataset were analysed for their theoretical validity. Results: Only 1 612 (45.7%) cases were identified as not including incoherent or contradictory responses. The cleaned-up data did not mirror the B5P- structure, as was envisaged. The test for common method bias was negative. Conclusion: In most cases the responses were incoherent. Cleaning up the data did not improve the psychometric properties of the BFI-10. This raises concerns about the quality of the WVS data, the BFI-10, and the universality of B5P-theory. Given these results, it would be unwise to use the BFI-10 in South Africa. Researchers are alerted to do a proper assessment of the psychometric properties of instruments before they use it, particularly in a cross-cultural setting

Leading Towards Voice and Innovation: The Role of Psychological Contract

Background: Empirical evidence generally suggests that psychological contract breach (PCB) leads to negative outcomes. However, some literature argues that, occasionally, PCB leads to positive outcomes. Aim: To empirically determine when these positive outcomes occur, focusing on the role of psychological contract (PC) and leadership style (LS), and outcomes such as employ voice (EV) and innovative work behaviour (IWB). Method: A cross-sectional survey design was adopted, using reputable questionnaires on PC, PCB, EV, IWB, and leadership styles. Correlation analyses were used to test direct links within the model, while regression analyses were used to test for the moderation effects. Results: Data with acceptable psychometric properties were collected from 11 organisations (N=620). The results revealed that PCB does not lead to substantial changes in IWB. PCB correlated positively with prohibitive EV, but did not influence promotive EV, which was a significant driver of IWB. Leadership styles were weak predictors of EV and IWB, and LS only partially moderated the PCB-EV relationship. Conclusion: PCB did not lead to positive outcomes. Neither did LS influencing the relationships between PCB and EV or IWB. Further, LS only partially influenced the relationships between variables, and not in a manner which positively influence IWB