3,422 research outputs found

    Inter-individual variation of the human epigenome & applications

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    Undergraduate Catalog of Studies, 2023-2024

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    Integrating expert-based objectivist and nonexpert-based subjectivist paradigms in landscape assessment

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    This thesis explores the integration of objective and subjective measures of landscape aesthetics, particularly focusing on crowdsourced geo-information. It addresses the increasing importance of considering public perceptions in national landscape governance, in line with the European Landscape Convention's emphasis on public involvement. Despite this, national landscape assessments often remain expert-centric and top-down, facing challenges in resource constraints and limited public engagement. The thesis leverages Web 2.0 technologies and crowdsourced geographic information, examining correlations between expert-based metrics of landscape quality and public perceptions. The Scenic-Or-Not initiative for Great Britain, GIS-based Wildness spatial layers, and LANDMAP dataset for Wales serve as key datasets for analysis. The research investigates the relationships between objective measures of landscape wildness quality and subjective measures of aesthetics. Multiscale geographically weighted regression (MGWR) reveals significant correlations, with different wildness components exhibiting varying degrees of association. The study suggests the feasibility of incorporating wildness and scenicness measures into formal landscape aesthetic assessments. Comparing expert and public perceptions, the research identifies preferences for water-related landforms and variations in upland and lowland typologies. The study emphasizes the agreement between experts and non-experts on extreme scenic perceptions but notes discrepancies in mid-spectrum landscapes. To overcome limitations in systematic landscape evaluations, an integrative approach is proposed. Utilizing XGBoost models, the research predicts spatial patterns of landscape aesthetics across Great Britain, based on the Scenic-Or-Not initiatives, Wildness spatial layers, and LANDMAP data. The models achieve comparable accuracy to traditional statistical models, offering insights for Landscape Character Assessment practices and policy decisions. While acknowledging data limitations and biases in crowdsourcing, the thesis discusses the necessity of an aggregation strategy to manage computational challenges. Methodological considerations include addressing the modifiable areal unit problem (MAUP) associated with aggregating point-based observations. The thesis comprises three studies published or submitted for publication, each contributing to the understanding of the relationship between objective and subjective measures of landscape aesthetics. The concluding chapter discusses the limitations of data and methods, providing a comprehensive overview of the research

    Numerical Simulations of Cavitating Bubbles in Elastic and Viscoelastic Materials for Biomedical Applications

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    The interactions of cavitating bubbles with elastic and viscoelastic materials play a central role in many biomedical applications. This thesis makes use of numerical modeling and data-driven approaches to characterize soft biomaterials at high strain rates via observation of bubble dynamics, and to model burst-wave lithotripsy, a focused ultrasound therapy to break kidney stones. In the first part of the thesis, a data assimilation framework is developed for cavitation rheometry, a technique that uses bubble dynamics to characterize soft, viscoelastic materials at high strain-rates. This framework aims to determine material properties that best fit observed cavitating bubble dynamics. We propose ensemble-based data assimilation methods to solve this inverse problem. This approach is validated with surrogate data generated by adding random noise to simulated bubble radius time histories, and we show that we can confidently and efficiently estimate parameters of interest within 5% given an iterative Kalman smoother approach and an ensemble- based 4D-Var hybrid technique. The developed framework is applied to experimental data in three distinct settings, with varying bubble nucleation methods, cavitation media, and using different material constitutive models. We demonstrate that the mechanical properties of gels used in each experiment can be estimated quickly and accurately despite experimental inconsistencies, model error, and noisy data. The framework is used to further our understanding of the underlying physics and identify limitations of our bubble dynamics model for violent bubble collapse. In the second part of the thesis, we simulate burst-wave lithotripsy (BWL), a non- invasive treatment for kidney stones that relies on repeated short bursts of focused ultrasound. Numerical approaches to study BWL require simulation of acoustic waves interacting with solid stones as well as bubble clouds which can nucleate ahead of the stone. We implement and validate a hypoelastic material model, which, with the addition of a continuum damage model and calibration of a spherically- focused transducer array, enables us to determine how effective various treatment strategies are with arbitrary stones. We present a preliminary investigation of the bubble dynamics occurring during treatment, and their impact on damage to the stone. Finally, we propose a strategy to reduce shielding by collapsing bubbles ahead of the stone via introduction of a secondary, low-frequency ultrasound pulse during treatment.</p

    Graduate Catalog of Studies, 2023-2024

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    A Trust Management Framework for Vehicular Ad Hoc Networks

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    The inception of Vehicular Ad Hoc Networks (VANETs) provides an opportunity for road users and public infrastructure to share information that improves the operation of roads and the driver experience. However, such systems can be vulnerable to malicious external entities and legitimate users. Trust management is used to address attacks from legitimate users in accordance with a user’s trust score. Trust models evaluate messages to assign rewards or punishments. This can be used to influence a driver’s future behaviour or, in extremis, block the driver. With receiver-side schemes, various methods are used to evaluate trust including, reputation computation, neighbour recommendations, and storing historical information. However, they incur overhead and add a delay when deciding whether to accept or reject messages. In this thesis, we propose a novel Tamper-Proof Device (TPD) based trust framework for managing trust of multiple drivers at the sender side vehicle that updates trust, stores, and protects information from malicious tampering. The TPD also regulates, rewards, and punishes each specific driver, as required. Furthermore, the trust score determines the classes of message that a driver can access. Dissemination of feedback is only required when there is an attack (conflicting information). A Road-Side Unit (RSU) rules on a dispute, using either the sum of products of trust and feedback or official vehicle data if available. These “untrue attacks” are resolved by an RSU using collaboration, and then providing a fixed amount of reward and punishment, as appropriate. Repeated attacks are addressed by incremental punishments and potentially driver access-blocking when conditions are met. The lack of sophistication in this fixed RSU assessment scheme is then addressed by a novel fuzzy logic-based RSU approach. This determines a fairer level of reward and punishment based on the severity of incident, driver past behaviour, and RSU confidence. The fuzzy RSU controller assesses judgements in such a way as to encourage drivers to improve their behaviour. Although any driver can lie in any situation, we believe that trustworthy drivers are more likely to remain so, and vice versa. We capture this behaviour in a Markov chain model for the sender and reporter driver behaviours where a driver’s truthfulness is influenced by their trust score and trust state. For each trust state, the driver’s likelihood of lying or honesty is set by a probability distribution which is different for each state. This framework is analysed in Veins using various classes of vehicles under different traffic conditions. Results confirm that the framework operates effectively in the presence of untrue and inconsistent attacks. The correct functioning is confirmed with the system appropriately classifying incidents when clarifier vehicles send truthful feedback. The framework is also evaluated against a centralized reputation scheme and the results demonstrate that it outperforms the reputation approach in terms of reduced communication overhead and shorter response time. Next, we perform a set of experiments to evaluate the performance of the fuzzy assessment in Veins. The fuzzy and fixed RSU assessment schemes are compared, and the results show that the fuzzy scheme provides better overall driver behaviour. The Markov chain driver behaviour model is also examined when changing the initial trust score of all drivers

    Graduate Catalog of Studies, 2023-2024

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    Multidisciplinary perspectives on Artificial Intelligence and the law

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    This open access book presents an interdisciplinary, multi-authored, edited collection of chapters on Artificial Intelligence (‘AI’) and the Law. AI technology has come to play a central role in the modern data economy. Through a combination of increased computing power, the growing availability of data and the advancement of algorithms, AI has now become an umbrella term for some of the most transformational technological breakthroughs of this age. The importance of AI stems from both the opportunities that it offers and the challenges that it entails. While AI applications hold the promise of economic growth and efficiency gains, they also create significant risks and uncertainty. The potential and perils of AI have thus come to dominate modern discussions of technology and ethics – and although AI was initially allowed to largely develop without guidelines or rules, few would deny that the law is set to play a fundamental role in shaping the future of AI. As the debate over AI is far from over, the need for rigorous analysis has never been greater. This book thus brings together contributors from different fields and backgrounds to explore how the law might provide answers to some of the most pressing questions raised by AI. An outcome of the Católica Research Centre for the Future of Law and its interdisciplinary working group on Law and Artificial Intelligence, it includes contributions by leading scholars in the fields of technology, ethics and the law.info:eu-repo/semantics/publishedVersio
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