Soft-connected Rigid Body Localization: State-of-the-Art and Research Directions for 6G

This white paper describes a proposed article that will aim to provide a thorough study of the evolution of the typical paradigm of wireless localization (WL), which is based on a single point model of each target, towards wireless rigid body localization (W-RBL). We also look beyond the concept of RBL itself, whereby each target is modeled as an independent multi-point three-dimensional (3D), with shape enforced via a set of conformation constraints, as a step towards a more general approach we refer to as soft-connected RBL, whereby an ensemble of several objects embedded in a given environment, is modeled as a set of soft-connected 3D objects, with rigid and soft conformation constraints enforced within each object and among them, respectively. A first intended contribution of the full version of this article is a compact but comprehensive survey on mechanisms to evolve WL algorithms in W-RBL schemes, considering their peculiarities in terms of the type of information, mathematical approach, and features the build on or offer. A subsequent contribution is a discussion of mechanisms to extend W-RBL techniques to soft-connected rigid body localization (SCW-RBL) algorithms

Developmental biology of wood formation

The wood-forming vascular cambium is responsible for the production of a large part of the biomass on this planet. Yet, there is only limited knowledge on how cell proliferation and differentiation in the cambial meristem are regulated. In this thesis the wood-forming tissues of aspen were used as a model system to identify and characterize molecular factors related to cambial meristem activity. An important regulator of cambial meristem activity is the plant hormone auxin. As polar transport is crucial for the delivery of auxin to the cambial zone, we identified homologues of known regulators of polar auxin transport and described their regulation by environmental and developmental factors. Translating changes in auxin concentration into changes in gene expression involves members of the Aux/IAA gene family. Aspen homologues of Aux/IAA genes were cloned and found to be expressed in a highly tissue-specific fashion, which is further influenced by developmental events and changes in the environment. A major response of trees to environmental changes is the suspension of meristematic growth during winter dormancy. A comparison of gene expression in active and dormant cambia revealed dramatic changes in the transcriptome including the expression of many cold and stress related genes during winter. During the process of wood formation, cells originating in the vascular cambium go through an elaborate process of cell division, cell expansion, secondary wall formation and programmed cell death. Large-scale analysis of gene expression was used to create transcriptional maps of the differentiation process. This extensive dataset allowed us to confirm the proposed functions of various genes involved in wood formation, assign other known genes to specific stages along the developmental gradient and identify a large number of novel potential regulators of wood formation. The data further suggest that the cambial meristem shares regulatory mechanisms with other meristems in addition to its own, specific factors

Automated histopathological analyses at scale

Thesis: S.M., Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, 2017.Cataloged from PDF version of thesis.Includes bibliographical references (pages 68-73).Histopathology is the microscopic examination of processed human tissues to diagnose conditions like cancer, tuberculosis, anemia and myocardial infractions. The diagnostic procedure is, however, very tedious, time-consuming and prone to misinterpretation. It also requires highly trained pathologists to operate, making it unsuitable for large-scale screening in resource-constrained settings, where experts are scarce and expensive. In this thesis, we present a software system for automated screening, backed by deep learning algorithms. This cost-effective, easily-scalable solution can be operated by minimally trained health workers and would extend the reach of histopathological analyses to settings such as rural villages, mass-screening camps and mobile health clinics. With metastatic breast cancer as our primary case study, we describe how the system could be used to test for the presence of a tumor, determine the precise location of a lesion, as well as the severity stage of a patient. We examine how the algorithms are combined into an end-to-end pipeline for utilization by hospitals, doctors and clinicians on a Software as a Service (SaaS) model. Finally, we discuss potential deployment strategies for the technology, as well an analysis of the market and distribution chain in the specific case of the current Indian healthcare ecosystem.by Mrinal Mohit.S.M

The water footprint assessment manual: setting the global standard

This book contains the global standard for \u27water footprint assessment\u27 as developed and maintained by the Water Footprint Network (WFN). It covers a comprehensive set of definitions and methods for water footprint accounting. It shows how water footprints are calculated for individual processes and products, as well as for consumers, nations and businesses. It also includes methods for water footprint sustainability assessment and a library of water footprint response options. A shared standard on definitions and calculation methods is crucial given the rapidly growing interest in companies and governments to use water footprint accounts as a basis for formulating sustainable water strategies and policies