Cross-species Conservation of context-specific networks

Background: Many large data compendia on context-specific high-throughput genomic and regulatory data have been made available by international research consortia such as ENCODE, TCGA, and Epigenomics Roadmap. The use of these resources is impaired by the sheer size of the available big data and big metadata. Many of these context-specific data can be modeled as data derived regulatory networks (DDRNs) representing the complex and complicated interactions between transcription factors and target genes. These DDRNs are useful for the understanding of regulatory mechanisms and helpful for interpreting biomedical data. Results: The Cross-species Conservation framework (CroCo) provides a network-oriented view on the ENCODE regulatory data (CroCo network repository), convenient ways to access and browse networks and metadata, and a method to combine networks across compendia, experimental techniques, and species (CroCo tool suite). DDRNs can be combined with additional information and networks derived from the literature, curated resources, and computational predictions in order to enable detailed exploration and cross checking of regulatory interactions. Applications of the CroCo framework range from simple evidence look-up for user-defined regulatory interactions to the identification of conserved sub-networks in diverse cell-lines, conditions, and even species. Conclusion: CroCo adds an intuitive unifying view on the data from the ENCODE projects via a comprehensive repository of derived context-specific regulatory networks and enables flexible cross-context, cross-species, and cross-compendia comparison via a basis set of analysis tools. The CroCo web-application and Cytoscape plug-in are freely available at: http://services.bio.ifi.lmu.de/croco-web. The web-page links to a detailed system description, a user guide, and tutorial videos presenting common use cases of the CroCo framework

Damage localization map using electromechanical impedance spectrums and inverse distance weighting interpolation: Experimental validation on thin composite structures

Piezoelectric sensors are widely used for structure health monitoring technique. In particular, electromechanical impedance techniques give simple and low-cost solutions for detecting damage in composite structures. The purpose of the method proposed in this article is to generate a damage localization map based on both indicators computed from electromechanical impedance spectrums and inverse distance weighting interpolation. The weights for the interpolation have a physical sense and are computed according to an exponential law of the measured attenuation of acoustic waves. One of the main advantages of the method, so-called data-driven method, is that only experimental data are used as inputs for our algorithm. It does not rely on any model. The proposed method has been validated on both one-dimensional and two-dimensional composite structures

Industrial implementation of intelligent system techniques for nuclear power plant condition monitoring

As the nuclear power plants within the UK age, there is an increased requirement for condition monitoring to ensure that the plants are still be able to operate safely. This paper describes the novel application of Intelligent Systems (IS) techniques to provide decision support to the condition monitoring of Nuclear Power Plant (NPP) reactor cores within the UK. The resulting system, BETA (British Energy Trace Analysis) is deployed within the UK’s nuclear operator and provides automated decision support for the analysis of refuelling data, a lead indicator of the health of AGR (Advanced Gas-cooled Reactor) nuclear power plant cores. The key contribution of this work is the improvement of existing manual, labour-intensive analysis through the application of IS techniques to provide decision support to NPP reactor core condition monitoring. This enables an existing source of condition monitoring data to be analysed in a rapid and repeatable manner, providing additional information relating to core health on a more regular basis than routine inspection data allows. The application of IS techniques addresses two issues with the existing manual interpretation of the data, namely the limited availability of expertise and the variability of assessment between different experts. Decision support is provided by four applications of intelligent systems techniques. Two instances of a rule-based expert system are deployed, the first to automatically identify key features within the refuelling data and the second to classify specific types of anomaly. Clustering techniques are applied to support the definition of benchmark behaviour, which is used to detect the presence of anomalies within the refuelling data. Finally data mining techniques are used to track the evolution of the normal benchmark behaviour over time. This results in a system that not only provides support for analysing new refuelling events but also provides the platform to allow future events to be analysed. The BETA system has been deployed within the nuclear operator in the UK and is used at both the engineering offices and on station to support the analysis of refuelling events from two AGR stations, with a view to expanding it to the rest of the fleet in the near future

Development of a typing behaviour recognition mechanism on Android

This paper proposes a biometric authentication system which use password based and behavioural traits (typing behaviours) authentication technology to establish user’s identity on a mobile phone. The proposed system can work on the latest smart phone platform. It uses mobile devices to capture user’s keystroke data and transmit it to web server. The authentication engine will establish if a user is genuine or fraudulent. In addition, a multiplier of the standard deviation “α” has been defined which aims to achieve the balance between security and usability. Experimental results indicate that the developed authentication system is highly reliable and very secure with an equal error rate is below 7.5%

Genes2Networks: Connecting Lists of Proteins by Using Background Literature-based Mammalian Networks

In recent years, in-silico literature-based mammalian protein-protein interaction network datasets have been developed. These datasets contain binary interactions extracted manually from legacy experimental biomedical research literature. Placing lists of genes or proteins identified as significantly changing in multivariate experiments, in the context of background knowledge about binary interactions, can be used to place these genes or proteins in the context of pathways and protein complexes.
Genes2Networks is a software system that integrates the content of ten mammalian literature-based interaction network datasets. Filtering to prune low-confidence interactions was implemented. Genes2Networks is delivered as a web-based service using AJAX. The system can be used to extract relevant subnetworks created from “seed” lists of human Entrez gene names. The output includes a dynamic linkable three color web-based network map, with a statistical analysis report that identifies significant intermediate nodes used to connect the seed list. Genes2Networks is available at http://actin.pharm.mssm.edu/genes2networks.
Genes2Network is a powerful web-based software application tool that can help experimental biologists to interpret high-throughput experimental results used in genomics and proteomics studies where the output of these experiments is a list of significantly changing genes or proteins. The system can be used to find relationships between nodes from the seed list, and predict novel nodes that play a key role in a common function

Nudging folks towards stronger password choices:providing certainty is the key

Persuading people to choose strong passwords is challenging. One way to influence password strength, as and when people are making the choice, is to tweak the choice architecture to encourage stronger choice. A variety of choice architecture manipulations i.e. “nudges”, have been trialled by researchers with a view to strengthening the overall password profile. None has made much of a difference so far. Here we report on our design of an influential behavioural intervention tailored to the password choice context: a hybrid nudge that significantly prompted stronger passwords.We carried out three longitudinal studies to analyse the efficacy of a range of “nudges” by manipulating the password choice architecture of an actual university web application. The first and second studies tested the efficacy of several simple visual framing “nudges”. Password strength did not budge. The third study tested expiration dates directly linked to password strength. This manipulation delivered a positive result: significantly longer and stronger passwords. Our main conclusion was that the final successful nudge provided participants with absolute certainty as to the benefit of a stronger password, and that it was this certainty that made the difference

Enabling Machine Understandable Exchange of Energy Consumption Information in Intelligent Domotic Environments

In the 21st century, all the major countries around the world are coming together to reduce the impact of energy generation and consumption on the global environment. Energy conservation and its efficient usage has become a top agenda on the desks of many governments. In the last decade, the drive to make homes automated and to deliver a better assisted living picked pace and the research into home automation systems accelerated, usually based on a centralized residential gateway. However most devised solutions fail to provide users with information about power consumption of different house appliances. The ability to collect power consumption information can lead us to have a more energy efficient society. The goal addressed in this paper is to enable residential gateways to provide the energy consumption information, in a machine understandable format, to support third party applications and services. To reach this goal, we propose a Semantic Energy Information Publishing Framework. The proposed framework publishes, for different appliances in the house, their power consumption information and other properties, in a machine understandable format. Appliance properties are exposed according to the existing semantic modeling supported by residential gateways, while instantaneous power consumption is modeled through a new modular Energy Profile ontolog