In Memory of the Holocaust: We Have Come a Long Way

Sermon delivered at the 18th Annual Christian Service in Memory of the Holocaust, St Peter\u27s (Erindale) Anglican Church, Mississauga, Ont, April 26, 1998

Twenty Years of Women\u27s Leadership: Have We Come A Long Way, Baby? *

I\u27d like to share with you some thoughts from my last 20 years of leadership study and what I\u27ve come to understand during this time about women in relationship to leadership. Consider these remarks personal reflections on some of what has been written and discussed about leadership and especially about how women relate to leadership. Let\u27s wonder together if we\u27ve come a long way in our thinking about leadership and how women\u27s unique voices relate to it. 20 years ago we were just beginning to think about leadership in a broader way than simply a series of skills and abilities. We were generally either thinking that leadership and management were the same thing, or thinking that leadership was the opposite of management, and it was good and management was not good. For example, Bennis wrote in 1989 that management is doing things right; leadership is doing the right thing. We hadn\u27t yet figured out that it\u27s possible to do both and to do both well

Structural insights in mammalian sialyltransferases and fucosyltransferases: We have come a long way, but it is still a long way down

Funding Information: The APC was funded by King Abdullah University of Science and Technology. M.C.: L.C. and A.R.S. acknowledge the King Abdullah University of Science and Technology (KAUST) for support. We thank Romina Oliva, University of Parthenope (Naples), for helpful comments. Thanks to the STEMskills Research and Education Lab team members for support.Mammalian cell surfaces are modified with complex arrays of glycans that play major roles in health and disease. Abnormal glycosylation is a hallmark of cancer; terminal sialic acid and fucose in particular have high levels in tumor cells, with positive implications for malignancy. Increased sialylation and fucosylation are due to the upregulation of a set of sialyltransferases (STs) and fucosyltransferases (FUTs), which are potential drug targets in cancer. In the past, several advances in glycostructural biology have been made with the determination of crystal structures of several important STs and FUTs in mammals. Additionally, how the independent evolution of STs and FUTs occurred with a limited set of global folds and the diverse modular ability of catalytic domains toward substrates has been elucidated. This review highlights advances in the understanding of the structural architecture, substrate binding interactions, and catalysis of STs and FUTs in mammals. While this general understanding is emerging, use of this information to design inhibitors of STs and FUTs will be helpful in providing further insights into their role in the manifestation of cancer and developing targeted therapeutics in cancer.publishersversionpublishe

We’ve Come a Long Way (Baby)! Or Have We? Evolving Intellectual Freedom Issues in the US and Florida

This paper analyzes a shifting landscape of intellectual freedom (IF) in and outside Florida for children, adolescents, teens and adults. National ideals stand in tension with local and state developments, as new threats are visible in historical, legal, and technological context. Examples include doctrinal shifts, legislative bills, electronic surveillance and recent attempts to censor books, classroom texts, and reading lists. Privacy rights for minors in Florida are increasingly unstable. New assertions of parental rights are part of a larger conservative animus. Proponents of IF can identify a lessening of ideals and standards that began after doctrinal fruition in the 1960s and 70s, and respond to related occurrences to help mitigate the impact of increasingly reactionary social and political currents. At the same time, progressive librarians can resist erosion of professional independence that comes when censorship pressures undermine core values. This paper is a post-imprint of an article originally published in the Journal of Intellectual Freedom and Privacy (Winter, 2017), with minor edits from the original published article. Some end notes (1, 30, 41 and 51) have been added – re-ordering original numeration to link the reader to subsequent articles, websites and/or occurrences

We’ve Come a Long Way Baby (Or Have we?): Banning Tobacco Advertising and Sponsorship in the European Union

In October 2000, Europe\u27s highest court struck down a Community directive that effectively banned advertising and sponsorship of tobacco products in the European Union. Regulation of tobacco products has been on the Community\u27s agenda for over a decade, but it was not until l998 that the necessary political support to enact any such legislation became available. The broad scope of the ensuing directive reflected the increasing awareness of the harmful health effects of tobacco, but this remains a controversial topic. The court decision may only be a temporary victory for the tobacco lobby since the Community still is determined to regulate tobacco advertising and sponsorship and has other options available in pursuit of this objective

Thinking About the Constitution at the Cusp

What do I mean in saying that we need to think about the Constitution at the cusp? I have in mind an image in which we have one way of thinking about the Constitution on one side of a line, and another way of thinking about the Constitution on the other. My sense is that we may have crossed such a line quite recently. I believe that we may be in a new constitutional order, different from the New Deal-Great Society constitutional order that existed from 1937 to sometime in the 1980s. If so, those of us who have been teaching constitutional law for a long time may find ourselves in the position of law professors in 1938 and 1939, whose way of thinking about the Constitution was developed in the 1920s: we are intimately familiar with a whole raft of cases that simply do not have much to do with the Constitution in this new constitutional order. A law professor who said in 1940 that the farm program at issue in Wickard v. Filburn would be unconstitutional under the standards the Court used in the 1920s might have been right, but his statement would also have been profoundly irrelevant. I sometimes have the same feeling about critical comments about the Supreme Court\u27s recent work: the criticisms are that the Court\u27s current actions are not what the Court would have done ten years ago, and that the Court\u27s actions are inconsistent with the way most law professors have come to understand the Constitution. This criticism may be true enough, but it is perhaps profoundly irrelevant