Performance Analysis of Fetal-Phonocardiogram Signal Denoising Using The Discrete Wavelet Transform

The obligation for comprehensive fetal heart rate investigation had driven to improve the passive and non-invasive diagnostic instruments despite the USG or CTG method. Fetal phonocardiography (f-PCG) utilizing the auscultation method met the above criteria, but its interpretation frequently disturbed by the presence of noise. For instance, maternal heart and body organ sounds, fetal movements noise, and ambient noise from the environment where it is recording are the noise that corrupted the f-PCG signal. In this work, the use of discrete wavelet transforms (DWT) to eliminate noise in the f-PCG signal with SNR as the performance parameters observed. It was observing the effect of changes in wavelet type and threshold type on the SNR value. The test was carried out on f-PCG data taken from physio.net. Initial SNR values ranged from -26.7 dB to -4.4 dB; after application of DWT procedure to f-PCG, SNR increased significantly. Based on the test results obtained, wavelet type coif1 with the soft threshold gave the best result with 11.69 dB in SNR value. The coif1 had a superior result than other mother wavelets that use in this work, so the fPCG signal analysis for fetal heart rate investigation suggested to use it.The obligation for comprehensive fetal heart rate investigation had driven to improve the passive and non-invasive diagnostic instruments despite the USG or CTG method. Fetal phonocardiography (f-PCG) utilizing the auscultation method met the above criteria, but its interpretation frequently disturbed by the presence of noise. For instance, maternal heart and body organ sounds, fetal movements noise, and ambient noise from the environment where it is recording are the noise that corrupted the f-PCG signal. In this work, the use of discrete wavelet transforms (DWT) to eliminate noise in the f-PCG signal with SNR as the performance parameters observed. It was observing the effect of changes in wavelet type and threshold type on the SNR value. The test was carried out on f-PCG data taken from physio.net. Initial SNR values ranged from -26.7 dB to -4.4 dB; after application of DWT procedure to f-PCG, SNR increased significantly. Based on the test results obtained, wavelet type coif1 with the soft threshold gave the best result with 11.69 dB in SNR value. The coif1 had a superior result than other mother wavelets that use in this work, so the fPCG signal analysis for fetal heart rate investigation suggested to use it

A Combined Model for Noise Reduction of Lung Sound Signals Based on Empirical Mode Decomposition and Artificial Neural Network

Computer analysis of Lung Sound (LS) signals has been proposed in recent years as a tool to analyze the lungs' status but there have always been main challenges, including the contamination of LS with environmental noises, which come from different sources of unlike intensities. One of the common methods in noise reduction of LS signals is based on thresholding on Discrete Wavelet Transform (DWT) coefficients or Empirical Mode Decomposition (EMD) of the signal, however, in these methods, it is necessary to calculate the SNR value to determine the appropriate threshold for noise removal. To solve this problem, a combined model based on EMD and Artificial Neural Network (ANN) trained with different SNRs (0, 5, 10, 15, and 20dB) is proposed in this research. The model can denoise white and pink noises in the range of -2 to 20dB without thresholding or even estimating SNR, and at the same time, keep the main content of the LS signal well. The proposed method is also compared with the EMD-custom method, and the results obtained from the SNR, and fit criteria indicate the absolute superiority of the proposed method. For example, at SNR = 0dB, the combined method can improve the SNR by 9.41 and 8.23dB for white and pink noises, respectively, while the corresponding values are respectively 5.89 and 4.31dB for the EMD-Custom method

An audio processing pipeline for acquiring diagnostic quality heart sounds via mobile phone

Recently, heart sound signals captured using mobile phones have been employed to develop data-driven heart disease detection systems. Such signals are generally captured in person by trained clinicians who can determine if the recorded heart sounds are of diagnosable quality. However, mobile phones have the potential to support heart health diagnostics, even where access to trained medical professionals is limited. To adopt mobile phones as self-diagnostic tools for the masses, we would need to have a mechanism to automatically establish that heart sounds recorded by non-expert users in uncontrolled conditions have the required quality for diagnostic purposes. This paper proposes a quality assessment and enhancement pipeline for heart sounds captured using mobile phones. The pipeline analyzes a heart sound and determines if it has the required quality for diagnostic tasks. Also, in cases where the quality of the captured signal is below the required threshold, the pipeline can improve the quality by applying quality enhancement algorithms. Using this pipeline, we can also provide feedback to users regarding the cause of low-quality signal capture and guide them towards a successful one. We conducted a survey of a group of thirteen clinicians with auscultation skills and experience. The results of this survey were used to inform and validate the proposed quality assessment and enhancement pipeline. We observed a high level of agreement between the survey results and fundamental design decisions within the proposed pipeline. Also, the results indicate that the proposed pipeline can reduce our dependency on trained clinicians for capture of diagnosable heart sounds

Exploring the Impact of Noise and Degradations on Heart Sound Classification Models

The development of data-driven heart sound classification models has been an active area of research in recent years. To develop such data-driven models in the first place, heart sound signals need to be captured using a signal acquisition device. However, it is almost impossible to capture noise-free heart sound signals due to the presence of internal and external noises in most situations. Such noises and degradations in heart sound signals can potentially reduce the accuracy of data-driven classification models. Although different techniques have been proposed in the literature to address the noise issue, how and to what extent different noise and degradations in heart sound signals impact the accuracy of data-driven classification models remains unexplored. To answer this question, we produced a synthetic heart sound dataset including normal and abnormal heart sounds contaminated with a variety of noise and degradations. We used this dataset to investigate the impact of noise and degradation in heart sound recordings on the performance of different classification models. The results show different noises and degradations affect the performance of heart sound classification models to a different extent; some are more problematic for classification models, and others are less destructive. Comparing the findings of this study with the results of a survey we previously carried out with a group of clinicians shows noise and degradations that are more detrimental to classification models are also more disruptive to accurate auscultation. The findings of this study can be leveraged to develop targeted heart sound quality enhancement approaches — which adapt the type and aggressiveness of quality enhancement based on the characteristics of noise and degradation in heart sound signals

NRC-Net: Automated noise robust cardio net for detecting valvular cardiac diseases using optimum transformation method with heart sound signals

Cardiovascular diseases (CVDs) can be effectively treated when detected early, reducing mortality rates significantly. Traditionally, phonocardiogram (PCG) signals have been utilized for detecting cardiovascular disease due to their cost-effectiveness and simplicity. Nevertheless, various environmental and physiological noises frequently affect the PCG signals, compromising their essential distinctive characteristics. The prevalence of this issue in overcrowded and resource-constrained hospitals can compromise the accuracy of medical diagnoses. Therefore, this study aims to discover the optimal transformation method for detecting CVDs using noisy heart sound signals and propose a noise robust network to improve the CVDs classification performance.For the identification of the optimal transformation method for noisy heart sound data mel-frequency cepstral coefficients (MFCCs), short-time Fourier transform (STFT), constant-Q nonstationary Gabor transform (CQT) and continuous wavelet transform (CWT) has been used with VGG16. Furthermore, we propose a novel convolutional recurrent neural network (CRNN) architecture called noise robust cardio net (NRC-Net), which is a lightweight model to classify mitral regurgitation, aortic stenosis, mitral stenosis, mitral valve prolapse, and normal heart sounds using PCG signals contaminated with respiratory and random noises. An attention block is included to extract important temporal and spatial features from the noisy corrupted heart sound.The results of this study indicate that,CWT is the optimal transformation method for noisy heart sound signals. When evaluated on the GitHub heart sound dataset, CWT demonstrates an accuracy of 95.69% for VGG16, which is 1.95% better than the second-best CQT transformation technique. Moreover, our proposed NRC-Net with CWT obtained an accuracy of 97.4%, which is 1.71% higher than the VGG16

ELECTRO-MECHANICAL DATA FUSION FOR HEART HEALTH MONITORING

Heart disease is a major public health problem and one of the leading causes of death worldwide. Therefore, cardiac monitoring is of great importance for the early detection and prevention of adverse conditions. Recently, there has been extensive research interest in long-term, continuous, and non-invasive cardiac monitoring using wearable technology. Here we introduce a wearable device for monitoring heart health. This prototype consists of three sensors to monitor electrocardiogram (ECG), phonocardiogram (PCG), and seismocardiogram (SCG) signals, integrated with a microcontroller module with Bluetooth wireless connectivity. We also created a custom printed circuit board (PCB) to integrate all the sensors into a compact design. Then, flexible housing for the electronic components was 3D printed using thermoplastic polyurethane (TPU). In addition, we developed peak detection algorithms and filtering programs to analyze the recorded cardiac signals. Our preliminary results show that the device can record all three signals in real-time. Initial results for signal interpretation come from a recurrent neural network (RNN) based machine learning algorithm, Long Short-Term Memory (LSTM), which is used to monitor and identify key features in the ECG data. The next phase of our research will include cross-examination of all three sensor signals, development of machine learning algorithms for PCG and SCG signals, and continuous improvement of the wearable device

Signal Processing Using Non-invasive Physiological Sensors

Non-invasive biomedical sensors for monitoring physiological parameters from the human body for potential future therapies and healthcare solutions. Today, a critical factor in providing a cost-effective healthcare system is improving patients' quality of life and mobility, which can be achieved by developing non-invasive sensor systems, which can then be deployed in point of care, used at home or integrated into wearable devices for long-term data collection. Another factor that plays an integral part in a cost-effective healthcare system is the signal processing of the data recorded with non-invasive biomedical sensors. In this book, we aimed to attract researchers who are interested in the application of signal processing methods to different biomedical signals, such as an electroencephalogram (EEG), electromyogram (EMG), functional near-infrared spectroscopy (fNIRS), electrocardiogram (ECG), galvanic skin response, pulse oximetry, photoplethysmogram (PPG), etc. We encouraged new signal processing methods or the use of existing signal processing methods for its novel application in physiological signals to help healthcare providers make better decisions

Automatic analysis and classification of cardiac acoustic signals for long term monitoring

Objective: Cardiovascular diseases are the leading cause of death worldwide resulting in over 17.9 million deaths each year. Most of these diseases are preventable and treatable, but their progression and outcomes are significantly more positive with early-stage diagnosis and proper disease management. Among the approaches available to assist with the task of early-stage diagnosis and management of cardiac conditions, automatic analysis of auscultatory recordings is one of the most promising ones, since it could be particularly suitable for ambulatory/wearable monitoring. Thus, proper investigation of abnormalities present in cardiac acoustic signals can provide vital clinical information to assist long term monitoring. Cardiac acoustic signals, however, are very susceptible to noise and artifacts, and their characteristics vary largely with the recording conditions which makes the analysis challenging. Additionally, there are challenges in the steps used for automatic analysis and classification of cardiac acoustic signals. Broadly, these steps are the segmentation, feature extraction and subsequent classification of recorded signals using selected features. This thesis presents approaches using novel features with the aim to assist the automatic early-stage detection of cardiovascular diseases with improved performance, using cardiac acoustic signals collected in real-world conditions. Methods: Cardiac auscultatory recordings were studied to identify potential features to help in the classification of recordings from subjects with and without cardiac diseases. The diseases considered in this study for the identification of the symptoms and characteristics are the valvular heart diseases due to stenosis and regurgitation, atrial fibrillation, and splitting of fundamental heart sounds leading to additional lub/dub sounds in the systole or diastole interval of a cardiac cycle. The localisation of cardiac sounds of interest was performed using an adaptive wavelet-based filtering in combination with the Shannon energy envelope and prior information of fundamental heart sounds. This is a prerequisite step for the feature extraction and subsequent classification of recordings, leading to a more precise diagnosis. Localised segments of S1 and S2 sounds, and artifacts, were used to extract a set of perceptual and statistical features using wavelet transform, homomorphic filtering, Hilbert transform and mel-scale filtering, which were then fed to train an ensemble classifier to interpret S1 and S2 sounds. Once sound peaks of interest were identified, features extracted from these peaks, together with the features used for the identification of S1 and S2 sounds, were used to develop an algorithm to classify recorded signals. Overall, 99 features were extracted and statistically analysed using neighborhood component analysis (NCA) to identify the features which showed the greatest ability in classifying recordings. Selected features were then fed to train an ensemble classifier to classify abnormal recordings, and hyperparameters were optimized to evaluate the performance of the trained classifier. Thus, a machine learning-based approach for the automatic identification and classification of S1 and S2, and normal and abnormal recordings, in real-world noisy recordings using a novel feature set is presented. The validity of the proposed algorithm was tested using acoustic signals recorded in real-world, non-controlled environments at four auscultation sites (aortic valve, tricuspid valve, mitral valve, and pulmonary valve), from the subjects with and without cardiac diseases; together with recordings from the three large public databases. The performance metrics of the methodology in relation to classification accuracy (CA), sensitivity (SE), precision (P+), and F1 score, were evaluated. Results: This thesis proposes four different algorithms to automatically classify fundamental heart sounds – S1 and S2; normal fundamental sounds and abnormal additional lub/dub sounds recordings; normal and abnormal recordings; and recordings with heart valve disorders, namely the mitral stenosis (MS), mitral regurgitation (MR), mitral valve prolapse (MVP), aortic stenosis (AS) and murmurs, using cardiac acoustic signals. The results obtained from these algorithms were as follows: • The algorithm to classify S1 and S2 sounds achieved an average SE of 91.59% and 89.78%, and F1 score of 90.65% and 89.42%, in classifying S1 and S2, respectively. 87 features were extracted and statistically studied to identify the top 14 features which showed the best capabilities in classifying S1 and S2, and artifacts. The analysis showed that the most relevant features were those extracted using Maximum Overlap Discrete Wavelet Transform (MODWT) and Hilbert transform. • The algorithm to classify normal fundamental heart sounds and abnormal additional lub/dub sounds in the systole or diastole intervals of a cardiac cycle, achieved an average SE of 89.15%, P+ of 89.71%, F1 of 89.41%, and CA of 95.11% using the test dataset from the PASCAL database. The top 10 features that achieved the highest weights in classifying these recordings were also identified. • Normal and abnormal classification of recordings using the proposed algorithm achieved a mean CA of 94.172%, and SE of 92.38%, in classifying recordings from the different databases. Among the top 10 acoustic features identified, the deterministic energy of the sound peaks of interest and the instantaneous frequency extracted using the Hilbert Huang-transform, achieved the highest weights. • The machine learning-based approach proposed to classify recordings of heart valve disorders (AS, MS, MR, and MVP) achieved an average CA of 98.26% and SE of 95.83%. 99 acoustic features were extracted and their abilities to differentiate these abnormalities were examined using weights obtained from the neighborhood component analysis (NCA). The top 10 features which showed the greatest abilities in classifying these abnormalities using recordings from the different databases were also identified. The achieved results demonstrate the ability of the algorithms to automatically identify and classify cardiac sounds. This work provides the basis for measurements of many useful clinical attributes of cardiac acoustic signals and can potentially help in monitoring the overall cardiac health for longer duration. The work presented in this thesis is the first-of-its-kind to validate the results using both, normal and pathological cardiac acoustic signals, recorded for a long continuous duration of 5 minutes at four different auscultation sites in non-controlled real-world conditions.Open Acces

Noise reduction method for the heart sound records from digital stethoscope

In recent years, digital instruments have been widely used in the medical area with the rapid development of digital technology. The digital stethoscope, which converts the acoustic sound waves in to electrical signals and then amplifies them, is gradually replacing the conventional acoustic stethoscope with the advantage of additional usage such as restoring, replaying and processing the signals for optimal listening. As the sounds are transmitted in to electrical form, they can be recorded for further signal processing. One of the major problems with recording heart sounds is noise corruption. Although there are many solutions available to noise reduction problems, it was found that most of them are based on the assumption that the noise is an additive white noise [1]. More research is required to find different de-noising techniques based on the specific noise present. Therefore, this study is motivated to answer the research question: ‘How might the noise be reduced from the heart sound records collected from digital stethoscope with suitable noise reduction method’. This research question is divided into three sub-questions, including the identification of the noise spectrum, the design of noise reduction method and the assessment of the method. In the identification stage, five main kinds of noise were chosen and their characteristics and spectrums were discussed. Compared with different kinds of adaptive filters, the suitable noise reduction filter for this study was confirmed. To assess the effect of the method, 68 pieces of sound resources were collected for the experiment. These sounds were selected based on the noise they contain. A special noise reduction method was developed for the noise. This method was tested and assessed with those sound samples by two factors: the noise level and the noise kind. The results of the experiment showed the effect of the noise reduction method for each kind of noise. The outcomes indicated that this method was suitable for heart sound noise reduction. The findings of this study, including the analysis of noise level and noise kind, indicated and concluded that the chosen method for heart sound noise reduction performed well. This is perhaps the first attempt to understand and assess the noise reduction method with classified heart sound signals which are collected from the real healthcare environment. This noise reduction method may provide a de-noising solution for the specific noise present in heart sound