Bio-Radar: sistema de aquisição de sinais vitais sem contacto

The Bio-Radar system is capable to measure vital signs accurately, namely the respiratory and cardiac signal, using electromagnetic waves. In this way, it is possible to monitor subjects remotely and comfortably for long periods of time. This system is based on the micro-Doppler effect, which relates the received signal phase variation with the distance change between the subject chest-wall and the radar antennas, which occurs due to the cardiopulmonary function. Considering the variety of applications where this system can be used, it is required to evaluate its performance when applied to real context scenarios and thus demonstrate the advantages that bioradar systems can bring to the general population. In this work, a bio-radar prototype was developed in order to verify the viability to be integrated in specific applications, using robust and low profile solutions that equally guarantee the general system performance while addressing the market needs. Considering these two perspectives to be improved, different level solutions were developed. On the hardware side, textile antennas were developed to be embedded in a car seat upholstery, thus reaching a low profile solution and easy to include in the industrialization process. Real context scenarios imply long-term monitoring periods, where involuntary body motion can occur producing high amplitude signals that overshadow the vital signs. Non-controlled monitoring environments might also produce time varying parasitic reflections that have a direct impact in the signal. Additionally, the subject's physical stature and posture during the monitoring period can have a different impact in the signals quality. Therefore, signal processing algorithms were developed to be robust to low quality signals and non-static scenarios. On the other hand, the bio-radar potential can also be maximized if the acquired signals are used pertinently to help identify the subject's psychophysiological state enabling one to act accordingly. The random body motion until now has been seen as a noisy source, however it can also provide useful information regarding subject's state. In this sense, the acquired vital signs as well as other body motions were used in machine learning algorithms with the goal to identify the subject's emotions and thus verify if the remotely acquired vital signs can also provide useful information.O sistema Bio-Radar permite medir sinais vitais com precisão, nomeadamente o sinal respiratório e cardíaco, utilizando ondas eletromagnéticas para esse fim. Desta forma, é possível monitorizar sujeitos de forma remota e confortável durante longos períodos de tempo. Este sistema é baseado no efeito de micro-Doppler, que relaciona a variação de fase do sinal recebido com a alteração da distância entre as antenas do radar e a caixa torácica do sujeito, que ocorre durante a função cardiopulmonar. Considerando a variedade de aplicações onde este sistema pode ser utilizado, é necessário avaliar o seu desempenho quando aplicado em contextos reais e assim demonstrar as vantagens que os sistemas bio-radar podem trazer à população geral. Neste trabalho, foi desenvolvido um protótipo do bio radar com o objetivo de verificar a viabilidade de integrar estes sistemas em aplicações específicas, utilizando soluções robustas e discretas que garantam igualmente o seu bom desempenho, indo simultaneamente de encontro às necessidades do mercado. Considerando estas duas perspetivas em que o sistema pode ser melhorado, foram desenvolvidas soluções de diferentes níveis. Do ponto de vista de hardware, foram desenvolvidas antenas têxteis para serem integradas no estofo de um banco automóvel, alcançando uma solução discreta e fácil de incluir num processo de industrialização. Contextos reais de aplicação implicam períodos de monitorização longos, onde podem ocorrer movimentos corporais involuntários que produzem sinais de elevada amplitude que se sobrepõem aos sinais vitais. Ambientes de monitorização não controlados podem produzir reflexões parasitas variantes no tempo que têm impacto direto no sinal. Adicionalmente, a estrutura física do sujeito e a sua postura durante o período de monitorização podem ter impactos diferentes na qualidade dos sinais. Desta forma, foram desenvolvidos algoritmos de processamento de sinal robustos a sinais de baixa qualidade e a cenários não estáticos. Por outro lado, o potencial do bio radar pode também ser maximizado se os sinais adquiridos forem pertinentemente utilizados de forma a ajudar a identificar o estado psicofisiológico do sujeito, permitindo mais tarde agir em conformidade. O movimento corporal aleatório que foi até agora visto como uma fonte de ruído, pode no entanto também fornecer informação útil sobre o estado do sujeito. Neste sentido, os sinais vitais e outros movimentos corporais adquiridos foram utilizados em algoritmos de aprendizagem automática com o objetivo de identificar as emoções do sujeito e assim verificar que sinais vitais adquiridos remotamente podem também conter informação útil.Programa Doutoral em Engenharia Eletrotécnic

Improving Maternal and Fetal Cardiac Monitoring Using Artificial Intelligence

Early diagnosis of possible risks in the physiological status of fetus and mother during pregnancy and delivery is critical and can reduce mortality and morbidity. For example, early detection of life-threatening congenital heart disease may increase survival rate and reduce morbidity while allowing parents to make informed decisions. To study cardiac function, a variety of signals are required to be collected. In practice, several heart monitoring methods, such as electrocardiogram (ECG) and photoplethysmography (PPG), are commonly performed. Although there are several methods for monitoring fetal and maternal health, research is currently underway to enhance the mobility, accuracy, automation, and noise resistance of these methods to be used extensively, even at home. Artificial Intelligence (AI) can help to design a precise and convenient monitoring system. To achieve the goals, the following objectives are defined in this research: The first step for a signal acquisition system is to obtain high-quality signals. As the first objective, a signal processing scheme is explored to improve the signal-to-noise ratio (SNR) of signals and extract the desired signal from a noisy one with negative SNR (i.e., power of noise is greater than signal). It is worth mentioning that ECG and PPG signals are sensitive to noise from a variety of sources, increasing the risk of misunderstanding and interfering with the diagnostic process. The noises typically arise from power line interference, white noise, electrode contact noise, muscle contraction, baseline wandering, instrument noise, motion artifacts, electrosurgical noise. Even a slight variation in the obtained ECG waveform can impair the understanding of the patient's heart condition and affect the treatment procedure. Recent solutions, such as adaptive and blind source separation (BSS) algorithms, still have drawbacks, such as the need for noise or desired signal model, tuning and calibration, and inefficiency when dealing with excessively noisy signals. Therefore, the final goal of this step is to develop a robust algorithm that can estimate noise, even when SNR is negative, using the BSS method and remove it based on an adaptive filter. The second objective is defined for monitoring maternal and fetal ECG. Previous methods that were non-invasive used maternal abdominal ECG (MECG) for extracting fetal ECG (FECG). These methods need to be calibrated to generalize well. In other words, for each new subject, a calibration with a trustable device is required, which makes it difficult and time-consuming. The calibration is also susceptible to errors. We explore deep learning (DL) models for domain mapping, such as Cycle-Consistent Adversarial Networks, to map MECG to fetal ECG (FECG) and vice versa. The advantages of the proposed DL method over state-of-the-art approaches, such as adaptive filters or blind source separation, are that the proposed method is generalized well on unseen subjects. Moreover, it does not need calibration and is not sensitive to the heart rate variability of mother and fetal; it can also handle low signal-to-noise ratio (SNR) conditions. Thirdly, AI-based system that can measure continuous systolic blood pressure (SBP) and diastolic blood pressure (DBP) with minimum electrode requirements is explored. The most common method of measuring blood pressure is using cuff-based equipment, which cannot monitor blood pressure continuously, requires calibration, and is difficult to use. Other solutions use a synchronized ECG and PPG combination, which is still inconvenient and challenging to synchronize. The proposed method overcomes those issues and only uses PPG signal, comparing to other solutions. Using only PPG for blood pressure is more convenient since it is only one electrode on the finger where its acquisition is more resilient against error due to movement. The fourth objective is to detect anomalies on FECG data. The requirement of thousands of manually annotated samples is a concern for state-of-the-art detection systems, especially for fetal ECG (FECG), where there are few publicly available FECG datasets annotated for each FECG beat. Therefore, we will utilize active learning and transfer-learning concept to train a FECG anomaly detection system with the least training samples and high accuracy. In this part, a model is trained for detecting ECG anomalies in adults. Later this model is trained to detect anomalies on FECG. We only select more influential samples from the training set for training, which leads to training with the least effort. Because of physician shortages and rural geography, pregnant women's ability to get prenatal care might be improved through remote monitoring, especially when access to prenatal care is limited. Increased compliance with prenatal treatment and linked care amongst various providers are two possible benefits of remote monitoring. If recorded signals are transmitted correctly, maternal and fetal remote monitoring can be effective. Therefore, the last objective is to design a compression algorithm that can compress signals (like ECG) with a higher ratio than state-of-the-art and perform decompression fast without distortion. The proposed compression is fast thanks to the time domain B-Spline approach, and compressed data can be used for visualization and monitoring without decompression owing to the B-spline properties. Moreover, the stochastic optimization is designed to retain the signal quality and does not distort signal for diagnosis purposes while having a high compression ratio. In summary, components for creating an end-to-end system for day-to-day maternal and fetal cardiac monitoring can be envisioned as a mix of all tasks listed above. PPG and ECG recorded from the mother can be denoised using deconvolution strategy. Then, compression can be employed for transmitting signal. The trained CycleGAN model can be used for extracting FECG from MECG. Then, trained model using active transfer learning can detect anomaly on both MECG and FECG. Simultaneously, maternal BP is retrieved from the PPG signal. This information can be used for monitoring the cardiac status of mother and fetus, and also can be used for filling reports such as partogram

Data Conversion Within Energy Constrained Environments

Within scientific research, engineering, and consumer electronics, there is a multitude of new discrete sensor-interfaced devices. Maintaining high accuracy in signal quantization while staying within the strict power-budget of these devices is a very challenging problem. Traditional paths to solving this problem include researching more energy-efficient digital topologies as well as digital scaling.;This work offers an alternative path to lower-energy expenditure in the quantization stage --- content-dependent sampling of a signal. Instead of sampling at a constant rate, this work explores techniques which allow sampling based upon features of the signal itself through the use of application-dependent analog processing. This work presents an asynchronous sampling paradigm, based off the use of floating-gate-enabled analog circuitry. The basis of this work is developed through the mathematical models necessary for asynchronous sampling, as well the SPICE-compatible models necessary for simulating floating-gate enabled analog circuitry. These base techniques and circuitry are then extended to systems and applications utilizing novel analog-to-digital converter topologies capable of leveraging the non-constant sampling rates for significant sample and power savings

Noncontact detection and analysis of respiratory function using microwave Doppler Radar

Real-time respiratory measurement with Doppler Radar has an important advantage in the monitoring of certain conditions such as sleep apnoea, sudden infant death syndrome (SIDS), and many other general clinical uses requiring fast nonwearable and non-contact measurement of the respiratory function. In this paper, we demonstrate the feasibility of using Doppler Radar in measuring the basic respiratory frequencies (via fast Fourier transform) for four different types of breathing scenarios: normal breathing, rapid breathing, slow inhalation-fast exhalation, and fast inhalation-slow exhalation conducted in a laboratory environment. A high correlation factor was achieved between the Doppler Radar-based measurements and the conventional measurement device, a respiration strap. We also extended this work from basic signal acquisition to extracting detailed features of breathing function (I: E ratio). This facilitated additional insights into breathing activity and is likely to trigger a number of new applications in respiratory medicine