Connecting the Brain to Itself through an Emulation.

Pilot clinical trials of human patients implanted with devices that can chronically record and stimulate ensembles of hundreds to thousands of individual neurons offer the possibility of expanding the substrate of cognition. Parallel trains of firing rate activity can be delivered in real-time to an array of intermediate external modules that in turn can trigger parallel trains of stimulation back into the brain. These modules may be built in software, VLSI firmware, or biological tissue as in vitro culture preparations or in vivo ectopic construct organoids. Arrays of modules can be constructed as early stage whole brain emulators, following canonical intra- and inter-regional circuits. By using machine learning algorithms and classic tasks known to activate quasi-orthogonal functional connectivity patterns, bedside testing can rapidly identify ensemble tuning properties and in turn cycle through a sequence of external module architectures to explore which can causatively alter perception and behavior. Whole brain emulation both (1) serves to augment human neural function, compensating for disease and injury as an auxiliary parallel system, and (2) has its independent operation bootstrapped by a human-in-the-loop to identify optimal micro- and macro-architectures, update synaptic weights, and entrain behaviors. In this manner, closed-loop brain-computer interface pilot clinical trials can advance strong artificial intelligence development and forge new therapies to restore independence in children and adults with neurological conditions

Neuromorphic, Digital and Quantum Computation with Memory Circuit Elements

Memory effects are ubiquitous in nature and the class of memory circuit elements - which includes memristors, memcapacitors and meminductors - shows great potential to understand and simulate the associated fundamental physical processes. Here, we show that such elements can also be used in electronic schemes mimicking biologically-inspired computer architectures, performing digital logic and arithmetic operations, and can expand the capabilities of certain quantum computation schemes. In particular, we will discuss few examples where the concept of memory elements is relevant to the realization of associative memory in neuronal circuits, spike-timing-dependent plasticity of synapses, digital and field-programmable quantum computing

A Comprehensive Workflow for General-Purpose Neural Modeling with Highly Configurable Neuromorphic Hardware Systems

In this paper we present a methodological framework that meets novel requirements emerging from upcoming types of accelerated and highly configurable neuromorphic hardware systems. We describe in detail a device with 45 million programmable and dynamic synapses that is currently under development, and we sketch the conceptual challenges that arise from taking this platform into operation. More specifically, we aim at the establishment of this neuromorphic system as a flexible and neuroscientifically valuable modeling tool that can be used by non-hardware-experts. We consider various functional aspects to be crucial for this purpose, and we introduce a consistent workflow with detailed descriptions of all involved modules that implement the suggested steps: The integration of the hardware interface into the simulator-independent model description language PyNN; a fully automated translation between the PyNN domain and appropriate hardware configurations; an executable specification of the future neuromorphic system that can be seamlessly integrated into this biology-to-hardware mapping process as a test bench for all software layers and possible hardware design modifications; an evaluation scheme that deploys models from a dedicated benchmark library, compares the results generated by virtual or prototype hardware devices with reference software simulations and analyzes the differences. The integration of these components into one hardware-software workflow provides an ecosystem for ongoing preparative studies that support the hardware design process and represents the basis for the maturity of the model-to-hardware mapping software. The functionality and flexibility of the latter is proven with a variety of experimental results

A Compact CMOS Memristor Emulator Circuit and its Applications

Conceptual memristors have recently gathered wider interest due to their diverse application in non-von Neumann computing, machine learning, neuromorphic computing, and chaotic circuits. We introduce a compact CMOS circuit that emulates idealized memristor characteristics and can bridge the gap between concepts to chip-scale realization by transcending device challenges. The CMOS memristor circuit embodies a two-terminal variable resistor whose resistance is controlled by the voltage applied across its terminals. The memristor 'state' is held in a capacitor that controls the resistor value. This work presents the design and simulation of the memristor emulation circuit, and applies it to a memcomputing application of maze solving using analog parallelism. Furthermore, the memristor emulator circuit can be designed and fabricated using standard commercial CMOS technologies and opens doors to interesting applications in neuromorphic and machine learning circuits.Comment: Submitted to International Symposium of Circuits and Systems (ISCAS) 201

Unsupervised learning in probabilistic neural networks with multi-state metal-oxide memristive synapses

In an increasingly data-rich world the need for developing computing systems that cannot only process, but ideally also interpret big data is becoming continuously more pressing. Brain-inspired concepts have shown great promise towards addressing this need. Here we demonstrate unsupervised learning in a probabilistic neural network that utilizes metal-oxide memristive devices as multi-state synapses. Our approach can be exploited for processing unlabelled data and can adapt to time-varying clusters that underlie incoming data by supporting the capability of reversible unsupervised learning. The potential of this work is showcased through the demonstration of successful learning in the presence of corrupted input data and probabilistic neurons, thus paving the way towards robust big-data processors

Bio-inspired Neuromorphic Computing Using Memristor Crossbar Networks

Bio-inspired neuromorphic computing systems built with emerging devices such as memristors have become an active research field. Experimental demonstrations at the network-level have suggested memristor-based neuromorphic systems as a promising candidate to overcome the von-Neumann bottleneck in future computing applications. As a hardware system that offers co-location of memory and data processing, memristor-based networks represent an efficient computing platform with minimal data transfer and high parallelism. Furthermore, active utilization of the dynamic processes during resistive switching in memristors can help realize more faithful emulation of biological device and network behaviors, with the potential to process dynamic temporal inputs efficiently. In this thesis, I present experimental demonstrations of neuromorphic systems using fabricated memristor arrays as well as network-level simulation results. Models of resistive switching behavior in two types of memristor devices, conventional first-order and recently proposed second-order memristor devices, will be first introduced. Secondly, experimental demonstration of K-means clustering through unsupervised learning in a memristor network will be presented. The memristor based hardware systems achieved high classification accuracy (93.3%) on the standard IRIS data set, suggesting practical networks can be built with optimized memristor devices. Thirdly, implementation of a partial differential equation (PDE) solver in memristor arrays will be discussed. This work expands the capability of memristor-based computing hardware from ‘soft’ to ‘hard’ computing tasks, which require very high precision and accurate solutions. In general first-order memristors are suitable to perform tasks that are based on vector-matrix multiplications, ranging from K-means clustering to PDE solvers. On the other hand, utilizing internal device dynamics in second-order memristors can allow natural emulation of biological behaviors and enable network functions such as temporal data processing. An effort to explore second-order memristor devices and their network behaviors will be discussed. Finally, we propose ideas to build large-size passive memristor crossbar arrays, including fabrication approaches, guidelines of device structure, and analysis of the parasitic effects in larger arrays.PHDElectrical EngineeringUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttps://deepblue.lib.umich.edu/bitstream/2027.42/147610/1/yjjeong_1.pd