2014 Conference Abstracts: Annual Undergraduate Research Conference at the Interface of Biology and Mathematics

Conference schedule and abstract book for the Sixth Annual Undergraduate Research Conference at the Interface of Biology and Mathematics Date: November 1-2, 2014Plenary Speakers: Joseph Tien, Associate Professor of Mathematics at The Ohio State University; and Jeremy Smith, Governor\u27s Chair at the University of Tennessee and Director of the University of Tennessee/Oak Ridge National Lab Center for Molecular Biophysic

Nonlinear stability and control study of highly maneuverable high performance aircraft, phase 2

This research should lead to the development of new nonlinear methodologies for the adaptive control and stability analysis of high angle-of-attack aircraft such as the F18 (HARV). The emphasis has been on nonlinear adaptive control, but associated model development, system identification, stability analysis and simulation is performed in some detail as well. Various models under investigation for different purposes are summarized in tabular form. Models and simulation for the longitudinal dynamics have been developed for all types except the nonlinear ordinary differential equation model. Briefly, studies completed indicate that nonlinear adaptive control can outperform linear adaptive control for rapid maneuvers with large changes in alpha. The transient responses are compared where the desired alpha varies from 5 degrees to 60 degrees to 30 degrees and back to 5 degrees in all about 16 sec. Here, the horizontal stabilator is the only control used with an assumed first-order linear actuator with a 1/30 sec time constant

Dynamics of Macrosystems; Proceedings of a Workshop, September 3-7, 1984

There is an increasing awareness of the important and persuasive role that instability and random, chaotic motion play in the dynamics of macrosystems. Further research in the field should aim at providing useful tools, and therefore the motivation should come from important questions arising in specific macrosystems. Such systems include biochemical networks, genetic mechanisms, biological communities, neutral networks, cognitive processes and economic structures. This list may seem heterogeneous, but there are similarities between evolution in the different fields. It is not surprising that mathematical methods devised in one field can also be used to describe the dynamics of another. IIASA is attempting to make progress in this direction. With this aim in view this workshop was held at Laxenburg over the period 3-7 September 1984. These Proceedings cover a broad canvas, ranging from specific biological and economic problems to general aspects of dynamical systems and evolutionary theory

CEAS/AIAA/ICASE/NASA Langley International Forum on Aeroelasticity and Structural Dynamics 1999

These proceedings represent a collection of the latest advances in aeroelasticity and structural dynamics from the world community. Research in the areas of unsteady aerodynamics and aeroelasticity, structural modeling and optimization, active control and adaptive structures, landing dynamics, certification and qualification, and validation testing are highlighted in the collection of papers. The wide range of results will lead to advances in the prediction and control of the structural response of aircraft and spacecraft

Advanced Geoscience Remote Sensing

Nowadays, advanced remote sensing technology plays tremendous roles to build a quantitative and comprehensive understanding of how the Earth system operates. The advanced remote sensing technology is also used widely to monitor and survey the natural disasters and man-made pollution. Besides, telecommunication is considered as precise advanced remote sensing technology tool. Indeed precise usages of remote sensing and telecommunication without a comprehensive understanding of mathematics and physics. This book has three parts (i) microwave remote sensing applications, (ii) nuclear, geophysics and telecommunication; and (iii) environment remote sensing investigations

Versatile LCP surface microelectrodes for combining electrophysiology and in vivo two-photon imaging in the murine CNS

Neurons and astrocytes are highly interconnected and form a complex cellular network for signal processing in the brain. The electrical activity of neurons and astroglial Ca2+ signals are tightly coupled. Parallel recording of electrical activity and Ca2+ signals can help to identify the molecular mechanisms of neuron-glia communications. In this work, flexible liquid crystal polymer microelectrode arrays for electrical recordings and stimulations during two-photon laser-scanning microscopy (2P-LSM) were developed. The arrays were designed for standard craniotomies used for cortical 2P-LSM in vivo imaging. Being of low weight, thin and flexible, they can be easily positioned between the dura mater and the glass coverslip. Three different designs were constructed: arrays (1) with eight circular electrodes (arranged in a matrix of three by three elements, sparing the center), (2) with sixteen circular electrodes (four by four matrix) and (3) with eight rectangular electrodes (placed in four groups of 2 single sites). The initial contact sites of gold were coated with nanoporous platinum to decrease the impedance of the electrode tissue contacts and to increase the charge transfer capability. The biocompatibility of the electrodes was confirmed by immuno-histochemistry. Electrical recordings and Ca2+-imaging were performed in mice with neuronal or astroglial expression of the genetically encoded Ca2+-sensor GCaMP3. With the sixteen channel electrode arrays, an estimation of the spatially resolved electrical activity pattern within the cranial window could be described. The eight channel arrays were used in studies for simultaneous acquisition of Ca2+ (using 2P-LSM) and electrical signals. In addition, Ca2+ signals could be elicited by electrical stimulation. Using different stimulation intensities and depth of anesthesia, the change of brain activity during transition from anesthetized to awake state was investigated. In addition, the LCP technology was transferred from the cortical to a spinal cord application.Neurone und Astrozyten bilden ein komplexes interagierendes zellulares Netzwerk zur Signalverarbeitung im Gehirn. Dabei sind die elektrische Aktivitäten der Nervenzellen und die Ca2+ Signale der Astrozyten eng aneinander gekoppelt. Parallele Aufzeichnungen der elektrischen Aktivität und der Ca2+ Signale können helfen, die molekularen Mechanismen der Neuron-Glia-Kommunikation zu identifizieren. Innerhalb dieser Arbeit wurden flexible Flüssigkristall-Polymer-Mikroelektrodenarrays für elektrische Aufzeichnungen und Stimulationen für die Zwei-Photonen-Laserscan- Mikroskopie (2P-LSM) entwickelt. Die Elektrodenarrays wurden für Standard-Kraniotomien entwickelt, die für die kortikale in vivo 2P-LSM verwendet werden. Sie sind dünn, flexibel und von geringem Gewicht und können leicht auf der Dura positioniert werden. Drei verschiedene Designs wurden konstruiert: Arrays (1) mit acht runden Elektroden (angeordnet in einer drei mal drei Matrix, ohne die mittlere Elektrode), (2) mit sechzehn kreisförmigen Elektroden (vier mal vier Matrix) und (3) mit acht rechteckigen Elektroden (angeordnet in vier Gruppen von zwei einzelnen Standorten). Die ursprünglichen Elektrodenkontakte aus Gold wurden mit nanoporösem Platin beschichtet, um die Gewebekontaktimpedanz zu verringern und die Ladungsübertragungsfähigkeit zu erhöhen. Die Biokompatibilität der Elektroden immunhistochemisch getestet. Elektrische Aktivität und Ca2+ Signale wurden bei Mäusen mit neuronaler oder astroglialer Expression des Ca2+-Indikators GCaMP3 aufgezeichnet. Mit den sechzehn Kanal-Elektroden-Arrays konnten die elektrische Aktivität entlang der Kortexoberfläche innerhalb der Kraniotomie charakterisiert werden. Die achtkanaligen Arrays wurden zur gleichzeitigen Erfassung von Ca2+ (mit 2P-LSM) und elektrischen Signalen verwendet. Darüber hinaus konnten Ca2+ Signale durch elektrische Stimulation hervorgerufen werden. Mit verschiedenen Stimulationsintensitäten und der Tiefe der Anästhesie (Isofluran) wurde die Veränderung der Hirnaktivität beim Übergang von anästhesiert zu wach beobachtet. Zusätzlich konnte die Flüssigkristall-Polymer -Technologie von der kortikalen auf die spinale Anwendung übertragen werden.- European Union / EUGlia-PhD - European Union / Neurofibre