2,226 research outputs found
Uncertainty in phylogenetic tree estimates
Estimating phylogenetic trees is an important problem in evolutionary
biology, environmental policy and medicine. Although trees are estimated, their
uncertainties are discarded by mathematicians working in tree space. Here we
explicitly model the multivariate uncertainty of tree estimates. We consider
both the cases where uncertainty information arises extrinsically (through
covariate information) and intrinsically (through the tree estimates
themselves). The importance of accounting for tree uncertainty in tree space is
demonstrated in two case studies. In the first instance, differences between
gene trees are small relative to their uncertainties, while in the second, the
differences are relatively large. Our main goal is visualization of tree
uncertainty, and we demonstrate advantages of our method with respect to
reproducibility, speed and preservation of topological differences compared to
visualization based on multidimensional scaling. The proposal highlights that
phylogenetic trees are estimated in an extremely high-dimensional space,
resulting in uncertainty information that cannot be discarded. Most
importantly, it is a method that allows biologists to diagnose whether
differences between gene trees are biologically meaningful, or due to
uncertainty in estimation.Comment: Final version accepted to Journal of Computational and Graphical
Statistic
Deconvolving mutational patterns of poliovirus outbreaks reveals its intrinsic fitness landscape.
Vaccination has essentially eradicated poliovirus. Yet, its mutation rate is higher than that of viruses like HIV, for which no effective vaccine exists. To investigate this, we infer a fitness model for the poliovirus viral protein 1 (vp1), which successfully predicts in vitro fitness measurements. This is achieved by first developing a probabilistic model for the prevalence of vp1 sequences that enables us to isolate and remove data that are subject to strong vaccine-derived biases. The intrinsic fitness constraints derived for vp1, a capsid protein subject to antibody responses, are compared with those of analogous HIV proteins. We find that vp1 evolution is subject to tighter constraints, limiting its ability to evade vaccine-induced immune responses. Our analysis also indicates that circulating poliovirus strains in unimmunized populations serve as a reservoir that can seed outbreaks in spatio-temporally localized sub-optimally immunized populations
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The fluviageny, a method for analyzing temporal river fragmentation using phylogenetics
textPhylogenetic trees have historically been used to determine evolutionary relatedness between organisms. In the past few decades, as we've developed increasingly powerful computational algorithms and toolsets for performing analyses using phylogenetic methods, the use of these trees has expanded into other areas, including biodiversity informatics and geoinformatics. This report proposes using phylogenetic methods to create "fluviagenies" - trees that represent the effects of river fragmentation over time caused by damming. Faculty at the Center for Research in Water Resources at the University of Texas worked to develop tools and documentation for automating the creation of river segment codes (a.k.a., "fluvcodes") based on spatiotemporal data. Python was used to generate fluviageny trees from lists of these codes. The resulting trees can be exported into the appropriate data format for use with various phylogenetics programs. The Fishes of Texas Database (fshesoftexas.org), a comprehensive geospatial database of Texas fish occurrences aggregated and normalized from 42 museum collections around the world, was employed to create an example of how this tool might be used to analyze and hypothesize changes in fish populations as a consequence of river fragmentation. Additionally, this paper serves to theorize and analyze past and future potential uses for phylogenetic trees in various other fields of informatics.Informatio
Linking pattern to process in cultural evolution: explaining material culture diversity among the Northern Khanty of Northwest Siberia
Book description: This volume offers an integrative approach to the application of evolutionary theory in studies of cultural transmission and social evolution and reveals the enormous range of ways in which Darwinian ideas can lead to productive empirical research, the touchstone of any worthwhile theoretical perspective. While many recent works on cultural evolution adopt a specific theoretical framework, such as dual inheritance theory or human behavioral ecology, Pattern and Process in Cultural Evolution emphasizes empirical analysis and includes authors who employ a range of backgrounds and methods to address aspects of culture from an evolutionary perspective. Editor Stephen Shennan has assembled archaeologists, evolutionary theorists, and ethnographers, whose essays cover a broad range of time periods, localities, cultural groups, and artifacts
Visualization of Barrier Tree Sequences Revisited
The increasing complexity of models for prediction of the native spatial structure of RNA molecules requires visualization methods that help to analyze and understand the models and their predictions. This paper improves the visualization method for sequences of barrier trees previously published by the authors. The barrier trees of these sequences are rough topological simplifications of changing
folding landscapes – energy landscapes in which kinetic folding takes place. The folding landscapes themselves are generated for RNA molecules where the number of nucleotides increases. Successive landscapes are thus correlated and so are the corresponding barrier trees. The landscape sequence is visualized by an animation of a barrier tree that changes with time. The animation is created by an adaption of the foresight layout with tolerance algorithm for dynamic graph layout problems. Since it is very general, the main ideas for the adaption are presented: construction and layout of a supergraph, and how to build the final animation from its layout. Our previous suggestions for heuristics lead to visually unpleasing results for some datasets and, generally, suffered from a poor usage of available screen space. We will present some new heuristics that improve the readability of the final animation
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Evolutionary and molecular foundations of multiple contemporary functions of the nitroreductase superfamily.
Insight regarding how diverse enzymatic functions and reactions have evolved from ancestral scaffolds is fundamental to understanding chemical and evolutionary biology, and for the exploitation of enzymes for biotechnology. We undertook an extensive computational analysis using a unique and comprehensive combination of tools that include large-scale phylogenetic reconstruction to determine the sequence, structural, and functional relationships of the functionally diverse flavin mononucleotide-dependent nitroreductase (NTR) superfamily (>24,000 sequences from all domains of life, 54 structures, and >10 enzymatic functions). Our results suggest an evolutionary model in which contemporary subgroups of the superfamily have diverged in a radial manner from a minimal flavin-binding scaffold. We identified the structural design principle for this divergence: Insertions at key positions in the minimal scaffold that, combined with the fixation of key residues, have led to functional specialization. These results will aid future efforts to delineate the emergence of functional diversity in enzyme superfamilies, provide clues for functional inference for superfamily members of unknown function, and facilitate rational redesign of the NTR scaffold
A combinatorial approach to angiosperm pollen morphology
Angiosperms (flowering plants) are strikingly diverse. This is clearly expressed in the morphology of their pollen grains, which are characterized by enormous variety in their shape and patterning. In this paper, I approach angiosperm pollen morphology from the perspective of enumerative combinatorics. This involves generating angiosperm pollen morphotypes by algorithmically combining character states and enumerating the results of these combinations. I use this approach to generate 3 643 200 pollen morphotypes, which I visualize using a parallel-coordinates plot. This represents a raw morphospace. To compare real-world and theoretical morphologies, I map the pollen of 1008 species of Neotropical angiosperms growing on Barro Colorado Island (BCI), Panama, onto this raw morphospace. This highlights that, in addition to their well-documented taxonomic diversity, Neotropical rainforests also represent an enormous reservoir of morphological diversity. Angiosperm pollen morphospace at BCI has been filled mostly by pollen morphotypes that are unique to single plant species. Repetition of pollen morphotypes among higher taxa at BCI reflects both constraint and convergence. This combinatorial approach to morphology addresses the complexity that results from large numbers of discrete character combinations and could be employed in any situation where organismal form can be captured by discrete morphological characters
Mapping phylogenetic trees to reveal distinct patterns of evolution
Evolutionary relationships are frequently described by phylogenetic trees, but a central barrier in many fields is the difficulty of interpreting data containing conflicting phylogenetic signals.We present a metric-based method for comparing trees which extracts distinct alternative evolutionary relationships embedded in data. We demonstrate detection and resolution of phylogenetic uncertainty in a recent study of anole lizards, leading to alternate hypotheses about their evolutionary relationships. We use our approach to compare trees derived from different genes of Ebolavirus and find that the VP30 gene has a distinct phylogenetic signature composed of three alternatives that differ in the deep branching structure
Genomic plasticity and rapid host switching can promote the evolution of generalism : a case study in the zoonotic pathogen Campylobacter
This work was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) grant BB/I02464X/1, the Medical Research Council (MRC) grants MR/M501608/1 and MR/L015080/1, and the Wellcome Trust grant 088786/C/09/Z. GM was supported by a NISCHR Health Research Fellowship (HF-14–13).Peer reviewedPublisher PD
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