A wearable mechatronic device for extracorporeal blood ultrafiltration

The interest in the design of portable and wearable medical devices is related to both the relevant clinical and social benefits for patients and the potential economic savings for national health services. Biomedical technologies are improving at a very fast rate and represent an extraordinary means to develop innovative portable and wearable devices which can help people live in a prosperous way, in particular reducing sorrow in case of disease. This leads to a widespread effort to develop devices which can execute at home therapies that are usually performed in hospitals. This thesis presents a new wearable and portable device for extracorporeal blood ultrafiltration, named WUF (Wearable UltraFiltration device), able to remove excess fluids from fluid overload patients with chronic kidney disease and/or congestive heart failure. The design requirements that a modern wearable device for extracorporeal ultrafiltration must meet have been identified thanks to a thorough literature review on previous similar proposals followed by an extensive risk analysis. The design of the WUF prototype has faced several difficulties, ranging from the identification or conceivement of safe and reliable components to the design of a compact and neat layout. For most components it was possible to identify commercial (off-the-shelf) products meeting the requirements, nonetheless for some others, specific investigations, studies and developments were needed and led to the design of customized solutions or the formulation of original approaches. The design of an effective, efficient, safe and reliable control architecture, based on two microcontrollers and one microcomputer, the implementation of the control logic and of a graphical user interface have been carried out too being essential features of such a mechatronic device. A backpack/trolley design has been chosen as the layout for the device, since such a solution guarantees the best tradeoff between miniaturization and ergonomics. The design introduces an original positioning of the vast majority of components in three independent planar panels: one for disposable components, one for non-disposable devices and one for electronic boards and controllers. This arrangement of components can drastically simplify and speed up the in-hospital operations needed before and after a therapy with the WUF

Technology applications

A summary of NASA Technology Utilization programs for the period of 1 December 1971 through 31 May 1972 is presented. An abbreviated description of the overall Technology Utilization Applications Program is provided as a background for the specific applications examples. Subjects discussed are in the broad headings of: (1) cancer, (2) cardiovascular disease, (2) medical instrumentation, (4) urinary system disorders, (5) rehabilitation medicine, (6) air and water pollution, (7) housing and urban construction, (8) fire safety, (9) law enforcement and criminalistics, (10) transportation, and (11) mine safety

Design and Validation of a Wearable, Continuous, and Non-Invasive Hydration Monitor that uses Ultrasonic Pulses to Detect Changes in Tissue Hydration Status

Chronic dehydration is an endemic problem for many population groups. Current methods of monitoring hydration status are invasive, time consuming, cannot be performed while exercising, and require lab resources. A proposed solution is a wearable, continuous, and non-invasive device that uses harm-free ultrasonic pulses to detect changes in tissue hydration status over time. Customer and engineering requirements were defined and used to guide the design process. Literature reviews were performed to identify essential information on dehydration, assess current methods, discover state of the art devices, and describe ultrasonic theory. Market research was performed to identify athletes as the target population group. An adjustable elastic nylon bicep band prototype was manufactured and the integration of more advanced components was proposed. The theoretical signal processing method used to detect hydration status was validated through initial tests with a prototype electrical system composed of a Teensy 3.1 board, two 18 kHz piezoceramic disc elements, and an Arduino/LabVIEW interface. Tests with aluminum, rubber, and sponge materials were performed to compare the signal response to propagation through materials with different acoustic properties and water contents. Finally, tests performed with dehydrated bovine muscle tissue revealed a statistically significant difference between hydrated and dehydrated tissue, a promising indication for future device refinement

User Interfaces for Patient-Centered Communication of Health Status and Care Progress

The recent trend toward patients participating in their own healthcare has opened up numerous opportunities for computing research. This dissertation focuses on how technology can foster this participation, through user interfaces to effectively communicate personal health status and care progress to hospital patients. I first characterize the design space for electronic information communication to patients through field studies conducted in multiple hospital settings. These studies utilize a combination of survey instruments, and low- and high-fidelity prototypes, including a document-editing prototype through which users can view and manage clinical data to automatically associate it with progress notes. The prototype, activeNotes, includes the first known techniques supporting clinical information requests directly within a document editor. A usage study with ICU physicians at New York-Presbyterian Hospital (NYP) substantiated our design and revealed how electronic information related to patient status and care progress is derived from a typical Electronic Health Record system. Insights gained from this study informed following studies to understand how to design abstracted, plain-language views suitable for patients. We gauged both patient and physician responses to information display prototypes deployed in patient rooms for a formative study exploring their design. Following my reports on this study, I discuss the design, development and pilot evaluations of a prototype Personal Health Record application providing live, abstracted clinical information for patients at NYP. The portal, evaluated by cardiothoracic surgery patients, is the first of its kind to allow patients to capture and monitor live data related to their care. Patient use of the portal influenced the subsequent design of tools to support users in making sense of online medication information. These tools, designed with nurses and pharmacists and evaluated by cardiothoracic surgery patients at NYP, were developed using topic modeling approaches and text analysis techniques. Embodied in a prototype called Remedy, they enable rapid filtering and comparison of medication-related search results, based on a number of website features and content topics. I conclude by discussing how findings from this series of studies can help shape the ongoing design and development of patient-centered technology

Health and Care Infrastructure Research and Innovation Centre final report 2014

Improving healthcare, while containing costs, demands sophisticated understanding of three core elements in healthcare systems: infrastructure, technology and services. Their tripartite relationship is extremely complex, not least because the pace of change for each is different. That creates considerable challenges in planning for future needs and makes the management of innovation and change difficult. [Continues.

Accessibility of Health Data Representations for Older Adults: Challenges and Opportunities for Design

Health data of consumer off-the-shelf wearable devices is often conveyed to users through visual data representations and analyses. However, this is not always accessible to people with disabilities or older people due to low vision, cognitive impairments or literacy issues. Due to trade-offs between aesthetics predominance or information overload, real-time user feedback may not be conveyed easily from sensor devices through visual cues like graphs and texts. These difficulties may hinder critical data understanding. Additional auditory and tactile feedback can also provide immediate and accessible cues from these wearable devices, but it is necessary to understand existing data representation limitations initially. To avoid higher cognitive and visual overload, auditory and haptic cues can be designed to complement, replace or reinforce visual cues. In this paper, we outline the challenges in existing data representation and the necessary evidence to enhance the accessibility of health information from personal sensing devices used to monitor health parameters such as blood pressure, sleep, activity, heart rate and more. By creating innovative and inclusive user feedback, users will likely want to engage and interact with new devices and their own data

Advances of Italian Machine Design

This 2028 Special Issue presents recent developments and achievements in the field of Mechanism and Machine Science coming from the Italian community with international collaborations and ranging from theoretical contributions to experimental and practical applications. It contains selected contributions that were accepted for presentation at the Second International Conference of IFToMM Italy, IFIT2018, that has been held in Cassino on 29 and 30 November 2018. This IFIT conference is the second event of a series that was established in 2016 by IFToMM Italy in Vicenza. IFIT was established to bring together researchers, industry professionals and students, from the Italian and the international community in an intimate, collegial and stimulating environment

2011-2012 annual report to the S.C. General Assembly and the S.C. Budget & Control Board

The South Carolina Centers of Economic Excellence publishes an annual report to the South Carolina Budget & Control Board with description of the SmartState program, snapshot of company partners, description for each Centers of Economic Excellence, program achievements, review board members, and COEE Council of Chairs members