2,067 research outputs found
Corneal stromal demarcation line after collagen cross-linking in corneal ectatic diseases: a review of the literature
Collagen cross-linking (CXL) is a relatively new conservative approach for progressive corneal ectasia, which is able to strengthen corneal tissue reforming new covalent bonds. Subjective and objective results following this method seem to be promising. In recent years, newer CXL protocols have been developed to perform more effective and less invasive procedures. The increasing diffusion of CXL in the corneal ectatic disease has increased the need to have actual indices regarding the efficacy of the treatment. Evaluation of demarcation line (DL), a transition zone between the cross-linked anterior corneal stroma and the untreated posterior corneal stroma, is considered a measurement of the depth of CXL treatment into the stroma. Some evidence in the literature emphasize that DL could be a measure of effectiveness of the CXL. On the contrary, some authors believe that the "the deeper, the better" principle is rather a simplistic approach for interpreting the clinical importance of the corneal stromal DL
Decision-making process framework at the planning phase of housing development project
Every housing development project needs to go through several procedures which consist of a decision-making process. By practising the decision-making process since the planning phase, the relevant decision-maker is assisted in analysing and organising all issues arise such as the problem in identification and selection of a suitable contractor for housing development. However, the decisions are made without knowing precisely what will happen in the future. The research’s primary purpose is to develop a process model for decision-making at Malaysia’s housing development planning phase. This study also examines the decision-making process practised among Malaysian private housing developers at the planning phase and classifies four main aspects of decision-making: methods, tools, criteria and information. The study then discovers whether the four main aspects (methods, tools, criteria and information) are strongly related to the decision making process. This study comprises the development of a theoretical framework by integrating the models that have been developed by numerous authors and researchers on the subject of decision making. Besides, 67 private housing developers have been chosen as respondents for a questionnaire survey in this study. The descriptive statistical analysis and the correlated analysis are conducted employing the Statistical Package for Social Sciences (SPSS). The results of this study show different findings for every four main aspects studied. However, it still answers the research objectives, and the relationship between the four main aspects of the decision-making process is accepted. This study is useful because it serves as a guide for private housing developers and governments in decision making at the planning phase of housing development. Moreover, this study provides a new process framework for decision making at the planning phase of housing development in Malaysia and assists housing developers and governments to make better predictions before proceeding to the construction phase
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Femtosecond Laser-Assisted In Situ Keratomileusis Treatment of Residual Refractive Error following Femtosecond Laser-Enabled Keratoplasty.
Purpose:To evaluate the safety and effectiveness of femtosecond laser-assisted in situ keratomileusis (LASIK) in the treatment of residual myopia and astigmatism following femtosecond laser-enabled keratoplasty (FLEK). Design:Retrospective case review. Methods:Chart review of all patients with prior FLEK who subsequently underwent femto-LASIK surgery after full suture removal was performed at the Gavin Herbert Eye Institute at the University of California, Irvine. A total of 14 eyes in 13 patients met this criterion, and their comprehensive examinations performed at standard intervals were reviewed. Main outcome measures include uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (CDVA) expressed as the logarithm of the minimum angle of resolution (logMAR), manifest refractive astigmatism, and spherical equivalent. Results:From the preoperative visit to the 3 month visit, all 14 eyes significantly improved in UDVA (logMAR, 0.93 ± 0.23 to 0.44 ± 0.32, P = 0.002) with no loss of CDVA (logMAR, 0.26 ± 0.19 to 0.18 ± 0.23, P = 0.50). All 14 eyes showed significant improvement in manifest refractive astigmatism (4.71 ± 1.77 to 2.18 ± 1.45 diopters (D), P = 0.003) and spherical equivalent (-2.57 ± 2.45 to -0.48 ± 0.83 D, P = 0.0007). There were no flap or graft complications as a result of femto-LASIK. Conclusions:Our findings suggest that femto-LASIK on eyes with prior FLEK is safe and effective in improving visual acuity and reducing residual astigmatism
Contact-mediated control of radial migration of corneal epithelial cells
We thank Darrin Sheppard and other staff at the University of Aberdeen Medical Research Facility for specialist technical assistance. We thank Patsy D. Goast for overnight microscope monitoring. This work was performed under the Biotechnology and Bioscience Research Council Grant number BB/E015840/1 to JMC.Peer reviewedPublisher PD
Image database system for glaucoma diagnosis support
Tato práce popisuje přehled standardních a pokročilých metod používaných k diagnose glaukomu v ranném stádiu. Na základě teoretických poznatků je implementován internetově orientovaný informační systém pro oční lékaře, který má tři hlavní cíle. Prvním cílem je možnost sdílení osobních dat konkrétního pacienta bez nutnosti posílat tato data internetem. Druhým cílem je vytvořit účet pacienta založený na kompletním očním vyšetření. Posledním cílem je aplikovat algoritmus pro registraci intenzitního a barevného fundus obrazu a na jeho základě vytvořit internetově orientovanou tři-dimenzionální vizualizaci optického disku. Tato práce je součásti DAAD spolupráce mezi Ústavem Biomedicínského Inženýrství, Vysokého Učení Technického v Brně, Oční klinikou v Erlangenu a Ústavem Informačních Technologií, Friedrich-Alexander University, Erlangen-Nurnberg.This master thesis describes a conception of standard and advanced eye examination methods used for glaucoma diagnosis in its early stage. According to the theoretical knowledge, a web based information system for ophthalmologists with three main aims is implemented. The first aim is the possibility to share medical data of a concrete patient without sending his personal data through the Internet. The second aim is to create a patient account based on a complete eye examination procedure. The last aim is to improve the HRT diagnostic method with an image registration algorithm for the fundus and intensity images and create an optic nerve head web based 3D visualization. This master thesis is a part of project based on DAAD co-operation between Department of Biomedical Engineering, Brno University of Technology, Eye Clinic in Erlangen and Department of Computer Science, Friedrich-Alexander University, Erlangen-Nurnberg.
Keratoviz-A multistage keratoconus severity analysis and visualization using deep learning and class activated maps
The detection of keratoconus has been a difficult and arduous process over the years for ophthalmologists who have devised traditional approaches of diagnosis including the slit-lamp examination and observation of thinning of the corneal. The main contribution of this paper is using deep learning models namely Resnet50 and EfficientNet to not just detect whether an eye has been infected with keratoconus or not but also accurately detect the stages of infection namely mild, moderate, and advanced. The dataset used consists of corneal topographic maps and pentacam images. Individually the models achieved 97% and 94% accuracy on the dataset. We have also employed class activated maps (CAM) to observe and help visualize which areas of the images are utilized when making classifications for the different stages of keratoconus. Using deep learning models to predict the detection and severity of the infection can drastically speed up and provide accurate results at the same time
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