Searching the Sky with CONFIGR-STARS

SyNAPSE program of the Defense Advanced Projects Research Agency (HRL Laboratories LLC, subcontract #801881-BS under DARPA prime contract HR0011-09-C-0001); CELEST, a National Science Foundation Science of Learning Center (SBE-0354378)CONFIGR-STARS, a new methodology based on a model of the human visual system, is developed for registration of star images. The algorithm first applies CONFIGR, a neural model that connects sparse and noisy image components. CONFIGR produces a web of connections between stars in a reference starmap or in a test patch of unknown location. CONFIGR-STARS splits the resulting, typically highly connected, web into clusters, or "constellations." Cluster geometry is encoded as a signature vector that records edge lengths and angles relative to the cluster’s baseline edge. The location of a test patch cluster is identified by comparing its signature to signatures in the codebook of a reference starmap, where cluster locations are known. Simulations demonstrate robust performance in spite of image perturbations and omissions, and across starmaps from different sources and seasons. Further studies would test CONFIGR-STARS and algorithm variations applied to very large starmaps and to other technologies that may employ geometric signatures. Open-source code, data, and demos are available from http://techlab.bu.edu/STARS/

Temporal Precision of Spike Trains in Extrastriate Cortex of the Behaving Macaque Monkey

How reliably do action potentials in cortical neurons encode information about a visual stimulus? Most physiological studies do not weigh the occurrences of particular action potentials as significant but treat them only as reflections of average neuronal excitation. We report that single neurons recorded in a previous study by Newsome et al. (1989; see also Britten et al. 1992) from cortical area MT in the behaving monkey respond to dynamic and unpredictable motion stimuli with a markedly reproducible temporal modulation that is precise to a few milliseconds. This temporal modulation is stimulus dependent, being present for highly dynamic random motion but absent when the stimulus translates rigidly

Stellar Evolutionary Models for Magellanic Clouds

We supplement current evolutionary computations concerning Magellanic Cloud stars by exploring the evolutionary behavior of canonical stellar models (i.e.,with inefficient core overshooting) with metallicities suitable for stars in the Clouds. After discussing the adequacy of the adopted evolutionary scenario, we present evolutionary sequences as computed following a selected sample of stellar models in the mass range 0.8-8 Mo from the Main Sequence till the C ignition or the onset of thermal pulses in the advanced Asymptotic Giant Branch phase. On this basis, cluster isochrones covering the range of ages from 100 Myr to 15 Gyr are presented and discussed. To allow a comparison with evolutionary investigations appeared in the recent literature, we computed additional sets of models which take into account moderate core overshooting during the H burning phase, discussing the comparison in terms of current uncertainties in the stellar evolutionary models. Selected predictions constraining the cluster ages are finally discussed, presenting a calibration of the difference in magnitude between the luminous MS termination and the He burning giants in terms of cluster age. Both evolutionary tracks and isochrones have been made available at the node http://gipsy.cjb.net as a first step of a planned ``Pisa Evolutionary Library''.Comment: 11 pages, 9 eps figures, A&A accepted, evolutionary tracks and isochrones available at http://gipsy.cjb.net at the link ``Pisa Evolutionary Library'

Visualizing Gene Clusters using Neighborhood Graphs in R

The visualization of cluster solutions in gene expression data analysis gives practitioners an understanding of the cluster structure of their data and makes it easier to interpret the cluster results. Neighborhood graphs allow for visual assessment of relationships between adjacent clusters. The number of clusters in gene expression data is for biological reasons rather large. As a linear projection of the data into 2 dimensions does not scale well in the number of clusters there is a need for new visualization techniques using non-linear arrangement of the clusters. The new visualization tool is implemented in the open source statistical computing environment R. It is demonstrated on microarray data from yeast

A domain-specific language and matrix-free stencil code for investigating electronic properties of Dirac and topological materials

We introduce PVSC-DTM (Parallel Vectorized Stencil Code for Dirac and Topological Materials), a library and code generator based on a domain-specific language tailored to implement the specific stencil-like algorithms that can describe Dirac and topological materials such as graphene and topological insulators in a matrix-free way. The generated hybrid-parallel (MPI+OpenMP) code is fully vectorized using Single Instruction Multiple Data (SIMD) extensions. It is significantly faster than matrix-based approaches on the node level and performs in accordance with the roofline model. We demonstrate the chip-level performance and distributed-memory scalability of basic building blocks such as sparse matrix-(multiple-) vector multiplication on modern multicore CPUs. As an application example, we use the PVSC-DTM scheme to (i) explore the scattering of a Dirac wave on an array of gate-defined quantum dots, to (ii) calculate a bunch of interior eigenvalues for strong topological insulators, and to (iii) discuss the photoemission spectra of a disordered Weyl semimetal.Comment: 16 pages, 2 tables, 11 figure

Monitoring of Single-Cell Responses in the Optic Tectum of Adult Zebrafish with Dextran-Coupled Calcium Dyes Delivered via Local Electroporation

Kassing V, Engelmann J, Kurtz R. Monitoring of Single-Cell Responses in the Optic Tectum of Adult Zebrafish with Dextran-Coupled Calcium Dyes Delivered via Local Electroporation. PLoS ONE. 2013;8(5): e62846.The zebrafish (Danio rerio) has become one of the major animal models for in vivo examination of sensory and neuronal computation. Similar to Xenopus tadpoles neural activity in the optic tectum, the major region controlling visually guided behavior, can be examined in zebrafish larvae by optical imaging. Prerequisites of these approaches are usually the transparency of larvae up to a certain age and the use of two-photon microscopy. This principle of fluorescence excitation was necessary to suppress crosstalk between signals from individual neurons, which is a critical issue when using membrane-permeant dyes. This makes the equipment to study neuronal processing costly and limits the approach to the study of larvae. Thus there is lack of knowledge about the properties of neurons in the optic tectum of adult animals. We established a procedure to circumvent these problems, enabling in vivo calcium imaging in the optic tectum of adult zebrafish. Following local application of dextran-coupled dyes single-neuron activity of adult zebrafish can be monitored with conventional widefield microscopy, because dye labeling remains restricted to tens of neurons or less. Among the neurons characterized with our technique we found neurons that were selective for a certain pattern orientation as well as neurons that responded in a direction-selective way to visual motion. These findings are consistent with previous studies and indicate that the functional integrity of neuronal circuits in the optic tectum of adult zebrafish is preserved with our staining technique. Overall, our protocol for in vivo calcium imaging provides a useful approach to monitor visual responses of individual neurons in the optic tectum of adult zebrafish even when only widefield microscopy is available. This approach will help to obtain valuable insight into the principles of visual computation in adult vertebrates and thus complement previous work on developing visual circuits