7,539 research outputs found
Machine Learning and Integrative Analysis of Biomedical Big Data.
Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues
Small data oversampling: improving small data prediction accuracy using the geometric SMOTE algorithm
Dissertation presented as the partial requirement for obtaining a Master's degree in Data Science and Advanced AnalyticsIn the age of Big Data, many machine learning tasks in numerous industries are still restricted due to the use of
small datasets. The limited availability of data often results in unsatisfactory prediction performance of
supervised learning algorithms and, consequently, poor decision making. The current research work aims to
mitigate the small dataset problem by artificial data generation in the pre-processing phase of the data analysis
process. The oversampling technique Geometric SMOTE is applied to generate new training instances and
enhance crisp data structures. Experimental results show a significant improvement on the prediction accuracy
when compared with the use of original, small datasets and over other oversampling techniques such as Random
Oversampling, SMOTE and Borderline SMOTE. These findings show that artificial data creation is a promising
approach to overcome the problem of small data in classification tasks
Learning Fast and Slow: PROPEDEUTICA for Real-time Malware Detection
In this paper, we introduce and evaluate PROPEDEUTICA, a novel methodology
and framework for efficient and effective real-time malware detection,
leveraging the best of conventional machine learning (ML) and deep learning
(DL) algorithms. In PROPEDEUTICA, all software processes in the system start
execution subjected to a conventional ML detector for fast classification. If a
piece of software receives a borderline classification, it is subjected to
further analysis via more performance expensive and more accurate DL methods,
via our newly proposed DL algorithm DEEPMALWARE. Further, we introduce delays
to the execution of software subjected to deep learning analysis as a way to
"buy time" for DL analysis and to rate-limit the impact of possible malware in
the system. We evaluated PROPEDEUTICA with a set of 9,115 malware samples and
877 commonly used benign software samples from various categories for the
Windows OS. Our results show that the false positive rate for conventional ML
methods can reach 20%, and for modern DL methods it is usually below 6%.
However, the classification time for DL can be 100X longer than conventional ML
methods. PROPEDEUTICA improved the detection F1-score from 77.54% (conventional
ML method) to 90.25%, and reduced the detection time by 54.86%. Further, the
percentage of software subjected to DL analysis was approximately 40% on
average. Further, the application of delays in software subjected to ML reduced
the detection time by approximately 10%. Finally, we found and discussed a
discrepancy between the detection accuracy offline (analysis after all traces
are collected) and on-the-fly (analysis in tandem with trace collection). Our
insights show that conventional ML and modern DL-based malware detectors in
isolation cannot meet the needs of efficient and effective malware detection:
high accuracy, low false positive rate, and short classification time.Comment: 17 pages, 7 figure
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