Ontologies on the semantic web

As an informational technology, the World Wide Web has enjoyed spectacular success. In just ten years it has transformed the way information is produced, stored, and shared in arenas as diverse as shopping, family photo albums, and high-level academic research. The “Semantic Web” was touted by its developers as equally revolutionary but has not yet achieved anything like the Web’s exponential uptake. This 17 000 word survey article explores why this might be so, from a perspective that bridges both philosophy and IT

The Unbearable Lightness of the Economics-Made-Fun Genre

Several commentators have argued that the Economics-Made-Fun (“EMF”) genre contains very little actual economics. As such, it would seem that criticisms of EMF do not apply economics more broadly. In this paper I take a contrary view, arguing that, in fact, at a deep conceptual level, the engine of EMF analyses is precisely the engine of mainstream economics. Specifically, I argue that both EMF and mainstream economics rest on a conceptual foundation known as the Principal of the Substitution of Similars (“PSS”). Understanding how PSS leads EMF practitioners to make claims well beyond what is warranted by their analysis also offers insight into how PSS leaves mainstream economists in danger of overestimating the power and scope of their analyses. I explore the consequences of such problems through an example of economic analysis of the U.S. housing market in the lead-up to the recent financial crisis.Methodology, Popular Economics, William Stanley Jevons, Ontology, Anthropology of Finance

Differences in transcription between free-living and CO_2-activated third-stage larvae of Haemonchus contortus

Background: The disease caused by Haemonchus contortus, a blood-feeding nematode of small ruminants, is of major economic importance worldwide. The infective third-stage larva (L3) of this gastric nematode is enclosed in a cuticle (sheath) and, once ingested with herbage by the host, undergoes an exsheathment process that marks the transition from the free-living (L3) to the parasitic (xL3) stage. This study explored changes in gene transcription associated with this transition and predicted, based on comparative analysis, functional roles for key transcripts in the metabolic pathways linked to larval development. Results: Totals of 101,305 (L3) and 105,553 (xL3) expressed sequence tags (ESTs) were determined using 454 sequencing technology, and then assembled and annotated; the most abundant transcripts encoded transthyretin-like, calcium-binding EF-hand, NAD(P)-binding and nucleotide-binding proteins as well as homologues of Ancylostoma-secreted proteins (ASPs). Using an in silico-subtractive analysis, 560 and 685 sequences were shown to be uniquely represented in the L3 and xL3 stages, respectively; the transcripts encoded ribosomal proteins, collagens and elongation factors (in L3), and mainly peptidases and other enzymes of amino acid catabolism (in xL3). Caenorhabditis elegans orthologues of transcripts that were uniquely transcribed in each L3 and xL3 were predicted to interact with a total of 535 other genes, all of which were involved in embryonic development. Conclusion: The present study indicated that some key transcriptional alterations taking place during the transition from the L3 to the xL3 stage of H. contortus involve genes predicted to be linked to the development of neuronal tissue (L3 and xL3), formation of the cuticle (L3) and digestion of host haemoglobin (xL3). Future efforts using next-generation sequencing and bioinformatic technologies should provide the efficiency and depth of coverage required for the determination of the complete transcriptomes of different developmental stages and/or tissues of H. contortus as well as the genome of this important parasitic nematode. Such advances should lead to a significantly improved understanding of the molecular biology of H. contortus and, from an applied perspective, to novel methods of intervention

Ontology-based methodology for error detection in software design

Improving the quality of a software design with the goal of producing a high quality software product continues to grow in importance due to the costs that result from poorly designed software. It is commonly accepted that multiple design views are required in order to clearly specify the required functionality of software. There is universal agreement as to the importance of identifying inconsistencies early in the software design process, but the challenge is how to reconcile the representations of the diverse views to ensure consistency. To address the problem of inconsistencies that occur across multiple design views, this research introduces the Methodology for Objects to Agents (MOA). MOA utilizes a new ontology, the Ontology for Software Specification and Design (OSSD), as a common information model to integrate specification knowledge and design knowledge in order to facilitate the interoperability of formal requirements modeling tools and design tools, with the end goal of detecting inconsistency errors in a design. The methodology, which transforms designs represented using the Unified Modeling Language (UML) into representations written in formal agent-oriented modeling languages, integrates object-oriented concepts and agent-oriented concepts in order to take advantage of the benefits that both approaches can provide. The OSSD model is a hierarchical decomposition of software development concepts, including ontological constructs of objects, attributes, behavior, relations, states, transitions, goals, constraints, and plans. The methodology includes a consistency checking process that defines a consistency framework and an Inter-View Inconsistency Detection technique. MOA enhances software design quality by integrating multiple software design views, integrating object-oriented and agent-oriented concepts, and defining an error detection method that associates rules with ontological properties