HiTrust: building cross-organizational trust relationship based on a hybrid negotiation tree

Small-world phenomena have been observed in existing peer-to-peer (P2P) networks which has proved useful in the design of P2P file-sharing systems. Most studies of constructing small world behaviours on P2P are based on the concept of clustering peer nodes into groups, communities, or clusters. However, managing additional multilayer topology increases maintenance overhead, especially in highly dynamic environments. In this paper, we present Social-like P2P systems (Social-P2Ps) for object discovery by self-managing P2P topology with human tactics in social networks. In Social-P2Ps, queries are routed intelligently even with limited cached knowledge and node connections. Unlike community-based P2P file-sharing systems, we do not intend to create and maintain peer groups or communities consciously. In contrast, each node connects to other peer nodes with the same interests spontaneously by the result of daily searches

A Survey on Service Composition Middleware in Pervasive Environments

The development of pervasive computing has put the light on a challenging problem: how to dynamically compose services in heterogeneous and highly changing environments? We propose a survey that defines the service composition as a sequence of four steps: the translation, the generation, the evaluation, and finally the execution. With this powerful and simple model we describe the major service composition middleware. Then, a classification of these service composition middleware according to pervasive requirements - interoperability, discoverability, adaptability, context awareness, QoS management, security, spontaneous management, and autonomous management - is given. The classification highlights what has been done and what remains to do to develop the service composition in pervasive environments

Statistical analysis of chemical computational systems with MULTIVESTA and ALCHEMIST

The chemical-oriented approach is an emerging paradigm for programming the behaviour of densely distributed and context-aware devices (e.g. in ecosystems of displays tailored to crowd steering, or to obtain profile-based coordinated visualization). Typically, the evolution of such systems cannot be easily predicted, thus making of paramount importance the availability of techniques and tools supporting prior-to-deployment analysis. Exact analysis techniques do not scale well when the complexity of systems grows: as a consequence, approximated techniques based on simulation assumed a relevant role. This work presents a new simulation-based distributed tool addressing the statistical analysis of such a kind of systems, which has been obtained by chaining two existing tools: MultiVeStA and Alchemist. The former is a recently proposed lightweight tool which allows to enrich existing discrete event simulators with distributed statistical analysis capabilities, while the latter is an efficient simulator for chemical-oriented computational systems. The tool is validated against a crowd steering scenario, and insights on the performance are provided by discussing how these scale distributing the analysis tasks on a multi-core architecture

Engineering simulations for cancer systems biology

Computer simulation can be used to inform in vivo and in vitro experimentation, enabling rapid, low-cost hypothesis generation and directing experimental design in order to test those hypotheses. In this way, in silico models become a scientific instrument for investigation, and so should be developed to high standards, be carefully calibrated and their findings presented in such that they may be reproduced. Here, we outline a framework that supports developing simulations as scientific instruments, and we select cancer systems biology as an exemplar domain, with a particular focus on cellular signalling models. We consider the challenges of lack of data, incomplete knowledge and modelling in the context of a rapidly changing knowledge base. Our framework comprises a process to clearly separate scientific and engineering concerns in model and simulation development, and an argumentation approach to documenting models for rigorous way of recording assumptions and knowledge gaps. We propose interactive, dynamic visualisation tools to enable the biological community to interact with cellular signalling models directly for experimental design. There is a mismatch in scale between these cellular models and tissue structures that are affected by tumours, and bridging this gap requires substantial computational resource. We present concurrent programming as a technology to link scales without losing important details through model simplification. We discuss the value of combining this technology, interactive visualisation, argumentation and model separation to support development of multi-scale models that represent biologically plausible cells arranged in biologically plausible structures that model cell behaviour, interactions and response to therapeutic interventions