467 research outputs found

    Simultaneous Multiparametric and Multidimensional Cardiovascular Magnetic Resonance Imaging

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    The optimal connection model for blood vessels segmentation and the MEA-Net

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    Vascular diseases have long been regarded as a significant health concern. Accurately detecting the location, shape, and afflicted regions of blood vessels from a diverse range of medical images has proven to be a major challenge. Obtaining blood vessels that retain their correct topological structures is currently a crucial research issue. Numerous efforts have sought to reinforce neural networks' learning of vascular geometric features, including measures to ensure the correct topological structure of the segmentation result's vessel centerline. Typically, these methods extract topological features from the network's segmentation result and then apply regular constraints to reinforce the accuracy of critical components and the overall topological structure. However, as blood vessels are three-dimensional structures, it is essential to achieve complete local vessel segmentation, which necessitates enhancing the segmentation of vessel boundaries. Furthermore, current methods are limited to handling 2D blood vessel fragmentation cases. Our proposed boundary attention module directly extracts boundary voxels from the network's segmentation result. Additionally, we have established an optimal connection model based on minimal surfaces to determine the connection order between blood vessels. Our method achieves state-of-the-art performance in 3D multi-class vascular segmentation tasks, as evidenced by the high values of Dice Similarity Coefficient (DSC) and Normalized Surface Dice (NSD) metrics. Furthermore, our approach improves the Betti error, LR error, and BR error indicators of vessel richness and structural integrity by more than 10% compared to other methods, and effectively addresses vessel fragmentation and yields blood vessels with a more precise topological structure.Comment: 19 page

    Modern meat: the next generation of meat from cells

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    Modern Meat is the first textbook on cultivated meat, with contributions from over 100 experts within the cultivated meat community. The Sections of Modern Meat comprise 5 broad categories of cultivated meat: Context, Impact, Science, Society, and World. The 19 chapters of Modern Meat, spread across these 5 sections, provide detailed entries on cultivated meat. They extensively tour a range of topics including the impact of cultivated meat on humans and animals, the bioprocess of cultivated meat production, how cultivated meat may become a food option in Space and on Mars, and how cultivated meat may impact the economy, culture, and tradition of Asia

    The Liver Tumor Segmentation Benchmark (LiTS)

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    In this work, we report the set-up and results of the Liver Tumor Segmentation Benchmark (LiTS), which was organized in conjunction with the IEEE International Symposium on Biomedical Imaging (ISBI) 2017 and the International Conferences on Medical Image Computing and Computer-Assisted Intervention (MICCAI) 2017 and 2018. The image dataset is diverse and contains primary and secondary tumors with varied sizes and appearances with various lesion-to-background levels (hyper-/hypo-dense), created in collaboration with seven hospitals and research institutions. Seventy-five submitted liver and liver tumor segmentation algorithms were trained on a set of 131 computed tomography (CT) volumes and were tested on 70 unseen test images acquired from different patients. We found that not a single algorithm performed best for both liver and liver tumors in the three events. The best liver segmentation algorithm achieved a Dice score of 0.963, whereas, for tumor segmentation, the best algorithms achieved Dices scores of 0.674 (ISBI 2017), 0.702 (MICCAI 2017), and 0.739 (MICCAI 2018). Retrospectively, we performed additional analysis on liver tumor detection and revealed that not all top-performing segmentation algorithms worked well for tumor detection. The best liver tumor detection method achieved a lesion-wise recall of 0.458 (ISBI 2017), 0.515 (MICCAI 2017), and 0.554 (MICCAI 2018), indicating the need for further research. LiTS remains an active benchmark and resource for research, e.g., contributing the liver-related segmentation tasks in http://medicaldecathlon.com/. In addition, both data and online evaluation are accessible via https://competitions.codalab.org/competitions/17094

    Characterising Shape Variation in the Human Right Ventricle Using Statistical Shape Analysis: Preliminary Outcomes and Potential for Predicting Hypertension in a Clinical Setting

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    Variations in the shape of the human right ventricle (RV) have previously been shown to be predictive of heart function and long term prognosis in Pulmonary Hypertension (PH), a deadly disease characterised by high blood pressure in the pulmonary arteries. The extent to which ventricular shape is also affected by non-pathological features such as sex, body mass index (BMI) and age is explored in this thesis. If fundamental differences in the shape of a structurally normal RV exist, these might also impact the success of a predictive model. This thesis evaluates the extent to which non-pathological features affect the shape of the RV and determines the best ways, in terms of procedure and analysis, to adapt the model to consistently predict PH. It also identifies areas where the statistical shape analysis procedure is robust, and considers the extent to which specific, non-pathological, characteristics impact the diagnostic potential of the statistical shape model. Finally, recommendations are made on next steps in the development of a classification procedure for PH. The dataset was composed of clinically-obtained, cardiovascular magnetic resonance images (CMR) from two independent sources; The University of Pittsburgh Medical Center and Newcastle University. Shape change is assessed using a 3D statistical shape analysis technique, which topologically maps heart meshes through an harmonic mapping approach to create a unique shape function for each shape. Proper Orthogonal Decomposition (POD) was applied to the complete set of shape functions in order to determine and rank a set of shape features (i.e. modes and corresponding coefficients from the decomposition). MRI scanning protocol produced the most significant difference in shape; a shape mode associated with detail at the RV apex and ventricular length from apex to base strongly correlated with the MRI sequence used to record each subject. Qualitatively, a protocol which skipped slices produced a shorter RV with less detail at the apex. Decomposition of sex, age and BMI also derives unique RV shape descriptors which correspond to anatomically meaningful features. The shape features are shown to be able to predict presence of PH. The predictive model can be improved by including BMI as a factor, but these improvements are mainly concentrated in identification of healthy subjects

    Magnetic-plasmonic nanoparticles for multimodal bioimaging and hyperthermia.

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    257 p.El término "teranóstica" hace referencia a la integración inteligente de diagnósticos y terapias. Esta capacidad de obtener imágenes y tratar tumores simultáneamente con nanopartículas puede resultar ventajosa frente a las técnicas convencionales de diagnóstico y terapia. Así, una ventaja adicional tanto para la obtención de imágenes como para el tratamiento es poder estudiar las enfermedades in vitro utilizando diversos métodos de obtención de imágenes y combinándolos con tratamientos novedosos.La síntesis y optimización de nanopartículas híbridas que combinan propiedades magnéticas y plasmónicas se ha estudiado durante esta tesis. Además, estas nanoestructuras pueden funcionalizarse con moléculas adicionales para aplicaciones en imagen e hipertermia. La utilización de estas nanopartículas híbridas se ha estudiado para su uso específico como agentes de contraste para resonancia magnética, dispersión Raman mejorada en la superficie y microscopía de fluorescencia en modelos celulares 2D y 3D y en modelos ex vivo. Además, se ha evaluado la aplicación de los híbridos para calentamiento fototérmico en modelos celular 2D y 3D y etiquetado específico de células en modelos celulares 2D

    The Liver Tumor Segmentation Benchmark (LiTS)

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    In this work, we report the set-up and results of the Liver Tumor Segmentation Benchmark (LiTS), which was organized in conjunction with the IEEE International Symposium on Biomedical Imaging (ISBI) 2017 and the International Conferences on Medical Image Computing and Computer-Assisted Intervention (MICCAI) 2017 and 2018. The image dataset is diverse and contains primary and secondary tumors with varied sizes and appearances with various lesion-to-background levels (hyper-/hypo-dense), created in collaboration with seven hospitals and research institutions. Seventy-five submitted liver and liver tumor segmentation algorithms were trained on a set of 131 computed tomography (CT) volumes and were tested on 70 unseen test images acquired from different patients. We found that not a single algorithm performed best for both liver and liver tumors in the three events. The best liver segmentation algorithm achieved a Dice score of 0.963, whereas, for tumor segmentation, the best algorithms achieved Dices scores of 0.674 (ISBI 2017), 0.702 (MICCAI 2017), and 0.739 (MICCAI 2018). Retrospectively, we performed additional analysis on liver tumor detection and revealed that not all top-performing segmentation algorithms worked well for tumor detection. The best liver tumor detection method achieved a lesion-wise recall of 0.458 (ISBI 2017), 0.515 (MICCAI 2017), and 0.554 (MICCAI 2018), indicating the need for further research. LiTS remains an active benchmark and resource for research, e.g., contributing the liver-related segmentation tasks in http://medicaldecathlon.com/. In addition, both data and online evaluation are accessible via https://competitions.codalab.org/competitions/17094.Bjoern Menze is supported through the DFG funding (SFB 824, subproject B12) and a Helmut-Horten-Professorship for Biomedical Informatics by the Helmut-Horten-Foundation. Florian Kofler is Supported by Deutsche Forschungsgemeinschaft (DFG) through TUM International Graduate School of Science and Engineering (IGSSE), GSC 81. An Tang was supported by the Fonds de recherche du Québec en Santé and Fondation de l’association des radiologistes du Québec (FRQS- ARQ 34939 Clinical Research Scholarship – Junior 2 Salary Award). Hongwei Bran Li is supported by Forschungskredit (Grant NO. FK-21- 125) from University of Zurich.Peer ReviewedArticle signat per 109 autors/es: Patrick Bilic 1,a,b, Patrick Christ 1,a,b, Hongwei Bran Li 1,2,∗,b, Eugene Vorontsov 3,a,b, Avi Ben-Cohen 5,a, Georgios Kaissis 10,12,15,a, Adi Szeskin 18,a, Colin Jacobs 4,a, Gabriel Efrain Humpire Mamani 4,a, Gabriel Chartrand 26,a, Fabian Lohöfer 12,a, Julian Walter Holch 29,30,69,a, Wieland Sommer 32,a, Felix Hofmann 31,32,a, Alexandre Hostettler 36,a, Naama Lev-Cohain 38,a, Michal Drozdzal 34,a, Michal Marianne Amitai 35,a, Refael Vivanti 37,a, Jacob Sosna 38,a, Ivan Ezhov 1, Anjany Sekuboyina 1,2, Fernando Navarro 1,76,78, Florian Kofler 1,13,57,78, Johannes C. Paetzold 15,16, Suprosanna Shit 1, Xiaobin Hu 1, Jana Lipková 17, Markus Rempfler 1, Marie Piraud 57,1, Jan Kirschke 13, Benedikt Wiestler 13, Zhiheng Zhang 14, Christian Hülsemeyer 1, Marcel Beetz 1, Florian Ettlinger 1, Michela Antonelli 9, Woong Bae 73, Míriam Bellver 43, Lei Bi 61, Hao Chen 39, Grzegorz Chlebus 62,64, Erik B. Dam 72, Qi Dou 41, Chi-Wing Fu 41, Bogdan Georgescu 60, Xavier Giró-i-Nieto 45, Felix Gruen 28, Xu Han 77, Pheng-Ann Heng 41, Jürgen Hesser 48,49,50, Jan Hendrik Moltz 62, Christian Igel 72, Fabian Isensee 69,70, Paul Jäger 69,70, Fucang Jia 75, Krishna Chaitanya Kaluva 21, Mahendra Khened 21, Ildoo Kim 73, Jae-Hun Kim 53, Sungwoong Kim 73, Simon Kohl 69, Tomasz Konopczynski 49, Avinash Kori 21, Ganapathy Krishnamurthi 21, Fan Li 22, Hongchao Li 11, Junbo Li 8, Xiaomeng Li 40, John Lowengrub 66,67,68, Jun Ma 54, Klaus Maier-Hein 69,70,7, Kevis-Kokitsi Maninis 44, Hans Meine 62,65, Dorit Merhof 74, Akshay Pai 72, Mathias Perslev 72, Jens Petersen 69, Jordi Pont-Tuset 44, Jin Qi 56, Xiaojuan Qi 40, Oliver Rippel 74, Karsten Roth 47, Ignacio Sarasua 51,12, Andrea Schenk 62,63, Zengming Shen 59,60, Jordi Torres 46,43, Christian Wachinger 51,12,1, Chunliang Wang 42, Leon Weninger 74, Jianrong Wu 25, Daguang Xu 71, Xiaoping Yang 55, Simon Chun-Ho Yu 58, Yading Yuan 52, Miao Yue 20, Liping Zhang 58, Jorge Cardoso 9, Spyridon Bakas 19,23,24, Rickmer Braren 6,12,30,a, Volker Heinemann 33,a, Christopher Pal 3,a, An Tang 27,a, Samuel Kadoury 3,a, Luc Soler 36,a, Bram van Ginneken 4,a, Hayit Greenspan 5,a, Leo Joskowicz 18,a, Bjoern Menze 1,2,a // 1 Department of Informatics, Technical University of Munich, Germany; 2 Department of Quantitative Biomedicine, University of Zurich, Switzerland; 3 Ecole Polytechnique de Montréal, Canada; 4 Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands; 5 Department of Biomedical Engineering, Tel-Aviv University, Israel; 6 German Cancer Consortium (DKTK), Germany; 7 Pattern Analysis and Learning Group, Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany; 8 Philips Research China, Philips China Innovation Campus, Shanghai, China; 9 School of Biomedical Engineering & Imaging Sciences, King’s College London, London, UK; 10 Institute for AI in Medicine, Technical University of Munich, Germany; 11 Department of Computer Science, Guangdong University of Foreign Studies, China; 12 Institute for diagnostic and interventional radiology, Klinikum rechts der Isar, Technical University of Munich, Germany; 13 Institute for diagnostic and interventional neuroradiology, Klinikum rechts der Isar,Technical University of Munich, Germany; 14 Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, China; 15 Department of Computing, Imperial College London, London, United Kingdom; 16 Institute for Tissue Engineering and Regenerative Medicine, Helmholtz Zentrum München, Neuherberg, Germany; 17 Brigham and Women’s Hospital, Harvard Medical School, USA; 18 School of Computer Science and Engineering, the Hebrew University of Jerusalem, Israel; 19 Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, PA, USA; 20 CGG Services (Singapore) Pte. Ltd., Singapore; 21 Medical Imaging and Reconstruction Lab, Department of Engineering Design, Indian Institute of Technology Madras, India; 22 Sensetime, Shanghai, China; 23 Department of Radiology, Perelman School of Medicine, University of Pennsylvania, USA; 24 Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, PA, USA; 25 Tencent Healthcare (Shenzhen) Co., Ltd, China; 26 The University of Montréal Hospital Research Centre (CRCHUM) Montréal, Québec, Canada; 27 Department of Radiology, Radiation Oncology and Nuclear Medicine, University of Montréal, Canada; 28 Institute of Control Engineering, Technische Universität Braunschweig, Germany; 29 Department of Medicine III, University Hospital, LMU Munich, Munich, Germany; 30 Comprehensive Cancer Center Munich, Munich, Germany; 31 Department of General, Visceral and Transplantation Surgery, University Hospital, LMU Munich, Germany; 32 Department of Radiology, University Hospital, LMU Munich, Germany; 33 Department of Hematology/Oncology & Comprehensive Cancer Center Munich, LMU Klinikum Munich, Germany; 34 Polytechnique Montréal, Mila, QC, Canada; 35 Department of Diagnostic Radiology, Sheba Medical Center, Tel Aviv university, Israel; 36 Department of Surgical Data Science, Institut de Recherche contre les Cancers de l’Appareil Digestif (IRCAD), France; 37 Rafael Advanced Defense System, Israel; 38 Department of Radiology, Hadassah University Medical Center, Jerusalem, Israel; 39 Department of Computer Science and Engineering, The Hong Kong University of Science and Technology, China; 40 Department of Electrical and Electronic Engineering, The University of Hong Kong, China; 41 Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong, China; 42 Department of Biomedical Engineering and Health Systems, KTH Royal Institute of Technology, Sweden; 43 Barcelona Supercomputing Center, Barcelona, Spain; 44 Eidgenössische Technische Hochschule Zurich (ETHZ), Zurich, Switzerland; 45 Signal Theory and Communications Department, Universitat Politecnica de Catalunya, Catalonia, Spain; 46 Universitat Politecnica de Catalunya, Catalonia, Spain; 47 University of Tuebingen, Germany; 48 Mannheim Institute for Intelligent Systems in Medicine, department of Medicine Mannheim, Heidelberg University, Germany; 49 Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University, Germany; 50 Central Institute for Computer Engineering (ZITI), Heidelberg University, Germany; 51 Department of Child and Adolescent Psychiatry, Ludwig-Maximilians-Universität, Munich, Germany; 52 Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, NY, USA; 53 Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, South Korea; 54 Department of Mathematics, Nanjing University of Science and Technology, China; 55 Department of Mathematics, Nanjing University, China; 56 School of Information and Communication Engineering, University of Electronic Science and Technology of China, China; 57 Helmholtz AI, Helmholtz Zentrum München, Neuherberg, Germany; 58 Department of Imaging and Interventional Radiology, Chinese University of Hong Kong, Hong Kong, China; 59 Beckman Institute, University of Illinois at Urbana-Champaign, USA; 60 Siemens Healthineers, USA; 61 School of Computer Science, the University of Sydney, Australia; 62 Fraunhofer MEVIS, Bremen, Germany; 63 Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany; 64 Diagnostic Image Analysis Group, Radboud University Medical Center, Nijmegen, The Netherlands; 65 Medical Image Computing Group, FB3, University of Bremen, Germany; 66 Departments of Mathematics, Biomedical Engineering, University of California, Irvine, USA; 67 Center for Complex Biological Systems, University of California, Irvine, USA; 68 Chao Family Comprehensive Cancer Center, University of California, Irvine, USA; 69 Division of Medical Image Computing, German Cancer Research Center (DKFZ), Heidelberg, Germany; 70 Helmholtz Imaging, Germany; 71 NVIDIA, Santa Clara, CA, USA; 72 Department of Computer Science, University of Copenhagen, Denmark; 73 Kakao Brain, Republic of Korea; 74 Institute of Imaging & Computer Vision, RWTH Aachen University, Germany; 75 Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, China; 76 Department of Radiation Oncology and Radiotherapy, Klinikum rechts der Isar, Technical University of Munich, Germany; 77 Department of computer science, UNC Chapel Hill, USA; 78 TranslaTUM - Central Institute for Translational Cancer Research, Technical University of Munich, GermanyPostprint (published version

    MRI changes in visceral fat in Crohn’s Disease

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    Crohn’s Disease (CD) is a chronic inflammatory disease of the gastrointestinal tract affecting 115,000 people in the UK alone. As a chronic illness, CD management requires a stepwise escalation of treatment measures tethered with constant monitoring of the disease activity levels and progression. Hence, non-invasive disease activity assessment methods form an essential part of the treatment process. Endoscopy is considered to be the traditional method for CD diagnosis and disease activity assessment which is invasive and may be uncomfortable for patients. As traditional MRI-based disease assessment methods rely on intravenous gadolinium for contrast enhancement, CD patients typically undergo repeated exposure to gadolinium administration which adds cost and carries the risk of nephrogenic systemic fibrosis, allergic reaction, and long-term brain deposition following repeated use. Hence, the development of contrast-free MRI-based disease activity metrics eliminates the risks associated with gadolinium and allows for a more frequent assessment of the disease progression. However, all developed cross-sectional CD activity metrics so far rely on a visual assessment by radiologists which can be subjective and time-consuming. The aim of this thesis is to examine established radiological hallmarks of CD and employ MRI imaging sequences along with image processing techniques to generate objective and quantitative disease activity measurements. The first part of this thesis investigates visceral fat hypertrophy also known as fat wrapping which refers to an abnormal growth of the mesenteric fat to partially cover the small or large intestine. While fat wrapping has been established as a characteristic of CD, the complex nature of visceral fat hinders detailed analysis of the effect of fat wrapping. Hence, an automated abdominal fat segmentation algorithm was developed to generate an objective measure of abdominal fat volumes which was used to study the differences in visceral fat revealing significant differences between CD patients and healthy volunteers. The second part of the thesis examines mesenteric blood flow in CD patients. CD is known to be associated with hypervascularity of the mesentery, including vascular dilation and wide spacing of the vasa recta. The arteries supply the small bowel branch to a series of intestinal arteries within the mesentery. A second algorithm was developed to automatically trace abdominal vessels on a time-of-flight MRA scans and measure the number of vessels’ branching points which also revealed significant differences between CD patients and HVs. This research has demonstrated the potential for MRI and image processing techniques to provide objective and quantitative measurements of disease activity in CD. The development of automated algorithms for abdominal fat segmentation and vessel tracing allows for a more accurate and efficient assessment of key radiological hallmarks of CD which are often overlooked. These techniques have the potential to improve the management of CD by providing non-invasive and more frequent assessments of disease activity and progression, without the risks associated with traditional contrast-enhanced methods
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