A Nonparametric Bayesian Approach to Uncovering Rat Hippocampal Population Codes During Spatial Navigation

Rodent hippocampal population codes represent important spatial information about the environment during navigation. Several computational methods have been developed to uncover the neural representation of spatial topology embedded in rodent hippocampal ensemble spike activity. Here we extend our previous work and propose a nonparametric Bayesian approach to infer rat hippocampal population codes during spatial navigation. To tackle the model selection problem, we leverage a nonparametric Bayesian model. Specifically, to analyze rat hippocampal ensemble spiking activity, we apply a hierarchical Dirichlet process-hidden Markov model (HDP-HMM) using two Bayesian inference methods, one based on Markov chain Monte Carlo (MCMC) and the other based on variational Bayes (VB). We demonstrate the effectiveness of our Bayesian approaches on recordings from a freely-behaving rat navigating in an open field environment. We find that MCMC-based inference with Hamiltonian Monte Carlo (HMC) hyperparameter sampling is flexible and efficient, and outperforms VB and MCMC approaches with hyperparameters set by empirical Bayes

D3^3PO - Denoising, Deconvolving, and Decomposing Photon Observations

The analysis of astronomical images is a non-trivial task. The D3PO algorithm addresses the inference problem of denoising, deconvolving, and decomposing photon observations. Its primary goal is the simultaneous but individual reconstruction of the diffuse and point-like photon flux given a single photon count image, where the fluxes are superimposed. In order to discriminate between these morphologically different signal components, a probabilistic algorithm is derived in the language of information field theory based on a hierarchical Bayesian parameter model. The signal inference exploits prior information on the spatial correlation structure of the diffuse component and the brightness distribution of the spatially uncorrelated point-like sources. A maximum a posteriori solution and a solution minimizing the Gibbs free energy of the inference problem using variational Bayesian methods are discussed. Since the derivation of the solution is not dependent on the underlying position space, the implementation of the D3PO algorithm uses the NIFTY package to ensure applicability to various spatial grids and at any resolution. The fidelity of the algorithm is validated by the analysis of simulated data, including a realistic high energy photon count image showing a 32 x 32 arcmin^2 observation with a spatial resolution of 0.1 arcmin. In all tests the D3PO algorithm successfully denoised, deconvolved, and decomposed the data into a diffuse and a point-like signal estimate for the respective photon flux components.Comment: 22 pages, 8 figures, 2 tables, accepted by Astronomy & Astrophysics; refereed version, 1 figure added, results unchanged, software available at http://www.mpa-garching.mpg.de/ift/d3po

Fast and scalable non-parametric Bayesian inference for Poisson point processes

We study the problem of non-parametric Bayesian estimation of the intensity function of a Poisson point process. The observations are $n$ independent realisations of a Poisson point process on the interval $[0,T]$. We propose two related approaches. In both approaches we model the intensity function as piecewise constant on $N$ bins forming a partition of the interval $[0,T]$. In the first approach the coefficients of the intensity function are assigned independent gamma priors, leading to a closed form posterior distribution. On the theoretical side, we prove that as $n\rightarrow\infty,$ the posterior asymptotically concentrates around the "true", data-generating intensity function at an optimal rate for $h$-H\"older regular intensity functions ($0 < h\leq 1$). In the second approach we employ a gamma Markov chain prior on the coefficients of the intensity function. The posterior distribution is no longer available in closed form, but inference can be performed using a straightforward version of the Gibbs sampler. Both approaches scale well with sample size, but the second is much less sensitive to the choice of $N$. Practical performance of our methods is first demonstrated via synthetic data examples. We compare our second method with other existing approaches on the UK coal mining disasters data. Furthermore, we apply it to the US mass shootings data and Donald Trump's Twitter data.Comment: 45 pages, 22 figure

Mixed membership stochastic blockmodels

Observations consisting of measurements on relationships for pairs of objects arise in many settings, such as protein interaction and gene regulatory networks, collections of author-recipient email, and social networks. Analyzing such data with probabilisic models can be delicate because the simple exchangeability assumptions underlying many boilerplate models no longer hold. In this paper, we describe a latent variable model of such data called the mixed membership stochastic blockmodel. This model extends blockmodels for relational data to ones which capture mixed membership latent relational structure, thus providing an object-specific low-dimensional representation. We develop a general variational inference algorithm for fast approximate posterior inference. We explore applications to social and protein interaction networks.Comment: 46 pages, 14 figures, 3 table