Integer programming based solution approaches for the train dispatching problem

Railroads face the challenge of competing with the trucking industry in a fastpaced environment. In this respect, they are working toward running freight trains on schedule and reducing travel times. The planned train schedules consist of departure and arrival times at main stations on the rail network. A detailed timetable, on the other hand, consists of the departure and arrival times of each train in each track section of its route. The train dispatching problem aims to determine detailed timetables over a rail network in order to minimize deviations from the planned schedule. We provide a new integer programming formulation for this problem based on a spacetime network; we propose heuristic algorithms to solve it and present computational results of these algorithms. Our approach includes some realistic constraints that have not been previously considered as well as all the assumptions and practical issues considered by the earlier works

A Molecular Biology Database Digest

Computational Biology or Bioinformatics has been defined as the application of mathematical and Computer Science methods to solving problems in Molecular Biology that require large scale data, computation, and analysis [18]. As expected, Molecular Biology databases play an essential role in Computational Biology research and development. This paper introduces into current Molecular Biology databases, stressing data modeling, data acquisition, data retrieval, and the integration of Molecular Biology data from different sources. This paper is primarily intended for an audience of computer scientists with a limited background in Biology

Quantum Annealing Applied to De-Conflicting Optimal Trajectories for Air Traffic Management

We present the mapping of a class of simplified air traffic management (ATM) problems (strategic conflict resolution) to quadratic unconstrained boolean optimization (QUBO) problems. The mapping is performed through an original representation of the conflict-resolution problem in terms of a conflict graph, where nodes of the graph represent flights and edges represent a potential conflict between flights. The representation allows a natural decomposition of a real world instance related to wind-optimal trajectories over the Atlantic ocean into smaller subproblems, that can be discretized and are amenable to be programmed in quantum annealers. In the study, we tested the new programming techniques and we benchmark the hardness of the instances using both classical solvers and the D-Wave 2X and D-Wave 2000Q quantum chip. The preliminary results show that for reasonable modeling choices the most challenging subproblems which are programmable in the current devices are solved to optimality with 99% of probability within a second of annealing time.Comment: Paper accepted for publication on: IEEE Transactions on Intelligent Transportation System

Evaluation of IoT-Based Computational Intelligence Tools for DNA Sequence Analysis in Bioinformatics

In contemporary age, Computational Intelligence (CI) performs an essential role in the interpretation of big biological data considering that it could provide all of the molecular biology and DNA sequencing computations. For this purpose, many researchers have attempted to implement different tools in this field and have competed aggressively. Hence, determining the best of them among the enormous number of available tools is not an easy task, selecting the one which accomplishes big data in the concise time and with no error can significantly improve the scientist's contribution in the bioinformatics field. This study uses different analysis and methods such as Fuzzy, Dempster-Shafer, Murphy and Entropy Shannon to provide the most significant and reliable evaluation of IoT-based computational intelligence tools for DNA sequence analysis. The outcomes of this study can be advantageous to the bioinformatics community, researchers and experts in big biological data