77,078 research outputs found

    Validation of a common data model for active safety surveillance research

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    Systematic analysis of observational medical databases for active safety surveillance is hindered by the variation in data models and coding systems. Data analysts often find robust clinical data models difficult to understand and ill suited to support their analytic approaches. Further, some models do not facilitate the computations required for systematic analysis across many interventions and outcomes for large datasets. Translating the data from these idiosyncratic data models to a common data model (CDM) could facilitate both the analysts' understanding and the suitability for large-scale systematic analysis. In addition to facilitating analysis, a suitable CDM has to faithfully represent the source observational database. Before beginning to use the Observational Medical Outcomes Partnership (OMOP) CDM and a related dictionary of standardized terminologies for a study of large-scale systematic active safety surveillance, the authors validated the model's suitability for this use by example

    Complexity stage model of the medical device development based on economic evaluation-MedDee

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    The development of a new product is essential for the progress and success of any company. The medical device market is very specific, which is challenging. Therefore, this paper assesses an economic model for medical device evaluation using the economic, health, technology regulatory, and present market knowledge to enable the cost-time conception for any applicant. The purpose of this study is to propose a comprehensive stage model of the medical device development to subsequently describe the financial expenditure of the entire development process. The identification of critical steps was based on the literature review, and analysis, and a comparison of the available medical device development stages and directives. Furthermore, a preliminary assessment of the medical device development steps and procedures on the basis of the interviews was performed. Six interviews were conducted with an average duration of one hour, focusing on areas: relevance and level of detail of the medical device development stages, involvement of economic methods, and applicability of the proposed model. Subsequently, the improvement and modification of the medical device investment process, based on respondents' responses, were conducted. The authors have proposed the complexity model MedDee-Medical Devices Development by Economic Evaluation. This model is comprised of six phases: initiation, concept, design, production, final verification, and market disposition in which the economic methods are incorporated.Web of Science125art. no. 175

    Report on the evaluation of surveillance systems relevant to zoonotic diseases in Kenya, 2015: A basis for design of an integrated human–livestock surveillance system

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    The Zoonoses in Livestock in Kenya (ZooLinK) is a project that seeks to enable Kenya develop an effective surveillance programme for zoonotic diseases (infectious diseases transmissible between animals and human beings). The surveillance programme will be integrated across both human and animal health sectors. To achieve this goal the project will work in close collaboration with Kenyan government departments in responsible for animal and human health. As a prelude to the start of the project, an evaluation of the existing surveillance systems for human and animal health was carried out. The evaluation focused on the national surveillance system and the systems at the western part of Kenya (Busia county, Kakamega county and Bungoma county) where the initial programme will be developed. In conducting the evaluation the investigators used key informant interviews, focused group discussion participant questionnaires, audio recordings and observation for data collection. Data analysis for the qualitative data focused on generating themes or theory around the responses obtained in the key informants interviews and focused group discussions. Univariate analysis was performed by use of simple proportions in calculation for surveillance system attributes like sensitivity, completeness, PVP and Timeliness for the human health surveillance systems. The findings of the evaluation revealed that there was poor linkage between animal health surveillance and the human health surveillance systems. None of the systems had surveillance structures dedicated to zoonotic diseases. Most practitioners used clinical signs for diagnosis of diseases with little reference to acceptable case definitions. Laboratory diagnosis in animal health services focused more on suspected notifiable diseases as opposed to being a standard operating procedure for diagnosis. In Human health services the health care facilities that had laboratory within the facility conducted laboratory diagnosis for cases referred by the clinicians. However, some clinicians preferred using clinical signs for diagnosis to avoid the wait or turn-around time in the laboratory. For effective surveillance of zoonoses to be realized it would be advisable to establish surveillance structures specific to zoonoses and the necessary resources allocated to the surveillance activities. In addition, an integrated approach that incorporated both human and animal disease surveillance should be employed in the surveillance of zoonoses

    Formal Probabilistic Analysis of a Wireless Sensor Network for Forest Fire Detection

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    Wireless Sensor Networks (WSNs) have been widely explored for forest fire detection, which is considered a fatal threat throughout the world. Energy conservation of sensor nodes is one of the biggest challenges in this context and random scheduling is frequently applied to overcome that. The performance analysis of these random scheduling approaches is traditionally done by paper-and-pencil proof methods or simulation. These traditional techniques cannot ascertain 100% accuracy, and thus are not suitable for analyzing a safety-critical application like forest fire detection using WSNs. In this paper, we propose to overcome this limitation by applying formal probabilistic analysis using theorem proving to verify scheduling performance of a real-world WSN for forest fire detection using a k-set randomized algorithm as an energy saving mechanism. In particular, we formally verify the expected values of coverage intensity, the upper bound on the total number of disjoint subsets, for a given coverage intensity, and the lower bound on the total number of nodes.Comment: In Proceedings SCSS 2012, arXiv:1307.802

    Patient Risk and Data Standards in Healthcare Supply Chain

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    Patient safety is one of the most important health care challenges. It is a big concern since 1 in every 10 patients around the world is affected by healthcare errors. The focus of this study is given to preventable adverse events that caused by the errors or system flaw that could have been avoided. In this study, simulation models are developed using Arena to evaluate the impact of GS1 data standards on patient risk in healthcare supply chain. The focus was given to the provider hospital supply chain operations where inventory discrepancy and performance deficiencies in recall, return, and outdate management can directly affect patient safety. Simulation models are developed for various systems and scenarios to compare different performance measures and analyze the impact of GS1. The results indicates that as the validation points are closer to the point of use, the number of recalled or outdated products administered to a patient are still reduced significantly so checking at the bedside or PAR is critical. But validation only at these points may cause some problems such as stock outs; therefore, validating in other locations is also needed

    Information and communication technology solutions for outdoor navigation in dementia

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    INTRODUCTION: Information and communication technology (ICT) is potentially mature enough to empower outdoor and social activities in dementia. However, actual ICT-based devices have limited functionality and impact, mainly limited to safety. What is an ideal operational framework to enhance this field to support outdoor and social activities? METHODS: Review of literature and cross-disciplinary expert discussion. RESULTS: A situation-aware ICT requires a flexible fine-tuning by stakeholders of system usability and complexity of function, and of user safety and autonomy. It should operate by artificial intelligence/machine learning and should reflect harmonized stakeholder values, social context, and user residual cognitive functions. ICT services should be proposed at the prodromal stage of dementia and should be carefully validated within the life space of users in terms of quality of life, social activities, and costs. DISCUSSION: The operational framework has the potential to produce ICT and services with high clinical impact but requires substantial investment

    Evaluation of a Cape Town Safety Intervention as a Model for Good Practice: A Partnership between Researchers, Community and Implementing Agency

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    VPUU has a wealth of experience to share and is engaged with broader national and international policymakers and implementing agencies. Researchers are grappling with the difficulty of providing a rigorous project evaluation for these collaborations which could identify project elements that work with a view to their replication. This paper traces the evolution of an evidence-based approach to violence prevention in the Western Cape Province of South Africa. The Violence Prevention through Urban Upgrading (VPUU) project in Cape Town uses such an approach, and relies on a 'whole-of-society' methodology as well. The project and the difficulty of its evaluation are discussed. A partnership between VPUU, researchers, the community and local government has revealed both opportunities and obstacles, which are the subjects of a case study described here
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