Simulation of droplet-based microfluidic lab-on-a-chip applications

This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, Aristotle University of Thessaloniki, University of Thessaly, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute.Miniaturization of biological and chemical assays in lab-on-a-chip systems is a highly topical field of research. Droplet-based microfluidic chips are types of these miniaturized systems. They expand the capability of assays with special features that are unreached by traditional workflows. In particular, small sample volumes, independent separated reaction units, high throughput, automation and parallelization of assays are prominent features of droplet-based microfluidic devices. Full custom centric design of droplet-based microfluidic lab-on-a-chip technology implicates a high system integration level and design complexity. Therefore advanced development methodologies are needed, comparable with the methods in electronic design automation. Our design and simulation toolkit meets these requirements for an agile and low-risk development of custom lab-on-a-chip devices. The system simulation approach enables a fast and precise prediction of complex microfluidic networks. This fact is confirmed by reference and benchmark experiments. The results show that the simulation correctly reproduces the experimental measurements.The German BMBF and the EU in the projects DiNaMiD, signature 0315591B and NoE Photonics4Life, Grant Agreement number: 224014

The Internet of Simulation: Enabling Agile Model Based Systems Engineering for Cyber-Physical Systems

The expansion of the Internet of Things (IoT) has resulted in a complex cyber-physical system of systems that is continually evolving. With ever more complex systems being developed and changed there has been an increasing reliance on simulation as a vital part of the design process. There is also a growing need for simulation integration and co-simulation in order to analyse the complex interactions between system components. To this end we propose that the Internet of Simulation (IoS) as an extension of IoT can be used to meet these needs. The IoS allows for multiple heterogeneous simulations to be integrated together for co-simulation. It's effect on the engineer process is to facilitate agile practices without sacrificing rigour. An Industry 4.0 example case study is provided showing how IoS could be utilized

Multi-paradigm modelling for cyber–physical systems: a descriptive framework

The complexity of cyber–physical systems (CPSS) is commonly addressed through complex workflows, involving models in a plethora of different formalisms, each with their own methods, techniques, and tools. Some workflow patterns, combined with particular types of formalisms and operations on models in these formalisms, are used successfully in engineering practice. To identify and reuse them, we refer to these combinations of workflow and formalism patterns as modelling paradigms. This paper proposes a unifying (Descriptive) Framework to describe these paradigms, as well as their combinations. This work is set in the context of Multi-Paradigm Modelling (MPM), which is based on the principle to model every part and aspect of a system explicitly, at the most appropriate level(s) of abstraction, using the most appropriate modelling formalism(s) and workflows. The purpose of the Descriptive Framework presented in this paper is to serve as a basis to reason about these formalisms, workflows, and their combinations. One crucial part of the framework is the ability to capture the structural essence of a paradigm through the concept of a paradigmatic structure. This is illustrated informally by means of two example paradigms commonly used in CPS: Discrete Event Dynamic Systems and Synchronous Data Flow. The presented framework also identifies the need to establish whether a paradigm candidate follows, or qualifies as, a (given) paradigm. To illustrate the ability of the framework to support combining paradigms, the paper shows examples of both workflow and formalism combinations. The presented framework is intended as a basis for characterisation and classification of paradigms, as a starting point for a rigorous formalisation of the framework (allowing formal analyses), and as a foundation for MPM tool development

AGILE Paradigm: The next generation collaborative MDO for the development of aeronautical systems

The research and innovation EU funded AGILE project has developed the next generation of aircraft Multidisciplinary Design and Optimization (MDO) processes, which target significant reductions in aircraft development costs and time to market, leading to more cost-effective and greener aircraft solutions. 19 industry, research and academia partners from Europe, Canada and Russia have developed solutions to cope with the challenges of collaborative design and optimization of complex aeronautical products. In order to accelerate the deployment of large-scale, collaborative multidisciplinary design and optimization, a novel approach, the so-called “AGILE Paradigm”, has been conceived. The AGILE Paradigm is defined as a “blueprint for MDO”, accelerating the deployment and the operations of collaborative “MDO systems” and enabling the development of complex products practiced by multi-site and cross-organizational design teams, having heterogeneous expertise. A set of technologies has been developed by the AGILE consortium to enable the implementation of the AGILE Paradigm principles, thus delivering not only an abstract formalization of the approach, but also an applicable framework. The collection of all the technologies constitutes the so-called “AGILE Framework”, which has been applied for the design and the optimization of multiple aircraft configurations. The ambition of the AGILE Paradigm was set to reduce the lead time of 40% with respect to the current state-of-the-art. This work reviews the evolution of the MDO systems, underlines the open challenges tackled by the AGILE project, and introduces the main architectural concepts behind the AGILE Paradigm. Thereafter, an overview of the application design cases is presented, focusing of the main challenges and achievements. The AGILE technologies enabled the consortium to formulate and to solve in 15 months 7 MDO applications in parallel for the development of 7 novel aircraft configurations, demonstrating time savings beyond the 40% goal

Streamlining Cross-Organizational Aircraft Development: Results from the AGILE Project

The research and innovation AGILE project developed the next generation of aircraft Multidisciplinary Design and Optimization processes, which target significant reductions in aircraft development costs and time to market, leading to more cost-effective and greener aircraft solutions. The high level objective is the reduction of the lead time of 40% with respect to the current state-of-the-art. 19 industry, research and academia partners from Europe, Canada and Russia developed solutions to cope with the challenges of collaborative design and optimization of complex products. In order to accelerate the deployment of large-scale, collaborative multidisciplinary design and optimization (MDO), a novel methodology, the so-called AGILE Paradigm, has been developed. Furthermore, the AGILE project has developed and released a set of open technologies enabling the implementation of the AGILE Paradigm approach. The collection of all the technologies constitutes AGILE Framework, which has been deployed for the design and the optimization of multiple aircraft configurations. This paper focuses on the application of the AGILE Paradigm on seven novel aircraft configurations, proving the achievement of the project’s objectives