Magnetic resonance imaging of obesity and metabolic disorders: Summary from the 2019 ISMRM Workshop

More than 100 attendees from Australia, Austria, Belgium, Canada, China, Germany, Hong Kong, Indonesia, Japan, Malaysia, the Netherlands, the Philippines, Republic of Korea, Singapore, Sweden, Switzerland, the United Kingdom, and the United States convened in Singapore for the 2019 ISMRM-sponsored workshop on MRI of Obesity and Metabolic Disorders. The scientific program brought together a multidisciplinary group of researchers, trainees, and clinicians and included sessions in diabetes and insulin resistance; an update on recent advances in water–fat MRI acquisition and reconstruction methods; with applications in skeletal muscle, bone marrow, and adipose tissue quantification; a summary of recent findings in brown adipose tissue; new developments in imaging fat in the fetus, placenta, and neonates; the utility of liver elastography in obesity studies; and the emerging role of radiomics in population-based “big data” studies. The workshop featured keynote presentations on nutrition, epidemiology, genetics, and exercise physiology. Forty-four proffered scientific abstracts were also presented, covering the topics of brown adipose tissue, quantitative liver analysis from multiparametric data, disease prevalence and population health, technical and methodological developments in data acquisition and reconstruction, newfound applications of machine learning and neural networks, standardization of proton density fat fraction measurements, and X-nuclei applications. The purpose of this article is to summarize the scientific highlights from the workshop and identify future directions of work

MEM and MEM4PP: new tools supporting the parallel generation of critical metrics in the evaluation of statistical models

This paper describes MEM and MEM4PP as new Stata tools and commands. They support the automatic reporting and selection of the best regression and classification models by adding supplemental performance metrics based on statistical post-estimation and custom computation. In particular, MEM provides helpful metrics, such as the maximum acceptable variance inflation factor (maxAcceptVIF) together with the maximum computed variance inflation factor (maxComputVIF) for ordinary least squares (OLS) regression, the maximum absolute value of the correlation coefficient in the predictors' correlation matrix (maxAbsVPMCC), the area under the curve of receiving operator characteristics (AUC-ROC), p and chi-squared of the goodness-of-fit (GOF) test for logit and probit, and also the maximum probability thresholds (maxProbNlogPenultThrsh and maxProbNlogLastThrsh) from Zlotnik and Abraira risk-prediction nomograms (nomolog) for logistic regressions. This new tool also performs the automatic identification of the list of variables if run after most regression commands. After simple successive invocations of MEM (in a .do file acting as a batch file), the collectible results are produced in the console or exported to specially designated files (one .csv for all models in a batch). MEM4PP is MEM?s version for parallel processing. It starts from the same batch (the same .do file with its path provided as a parameter) and triggers different instances of Stata to parallelly generate the same results (one .csv for each model in a batch). The paper also includes some examples using real-world data from the World Values Survey (the evidence between 1981 and 2020, version number 1.6). They help us understand how MEM and MEM4PP support the testing of predictor independence, reverse causality checks, the best model selection starting from such metrics, and, ultimately, the replication of all these stepsIn terms of technical aid (https://cloud.raas.uaic.ro (accessed on 24 August 2022), as a private cloud of the Alexandru Ioan Cuza University of Iași, Romania), this paper also benefited from the support of the Competitiveness Operational Programme Romania, project number SMIS 124759, RaaS-IS (Research as a Service Iasi) id POC/398/1/124759. This work was also technically supported by the following project we would like to thank: VP50 “Development and validation of software tools and methodologies to provide individualized feedback and automatic performance assessment in programming learning’’, funded by Consejería de Universidades, Igualdad, Cultura y Deporte del Gobierno de Cantabria

Sequential decision making in artificial musical intelligence

Over the past 60 years, artificial intelligence has grown from a largely academic field of research to a ubiquitous array of tools and approaches used in everyday technology. Despite its many recent successes and growing prevalence, certain meaningful facets of computational intelligence have not been as thoroughly explored. Such additional facets cover a wide array of complex mental tasks which humans carry out easily, yet are difficult for computers to mimic. A prime example of a domain in which human intelligence thrives, but machine understanding is still fairly limited, is music. Over the last decade, many researchers have applied computational tools to carry out tasks such as genre identification, music summarization, music database querying, and melodic segmentation. While these are all useful algorithmic solutions, we are still a long way from constructing complete music agents, able to mimic (at least partially) the complexity with which humans approach music. One key aspect which hasn't been sufficiently studied is that of sequential decision making in musical intelligence. This thesis strives to answer the following question: Can a sequential decision making perspective guide us in the creation of better music agents, and social agents in general? And if so, how? More specifically, this thesis focuses on two aspects of musical intelligence: music recommendation and human-agent (and more generally agent-agent) interaction in the context of music. The key contributions of this thesis are the design of better music playlist recommendation algorithms; the design of algorithms for tracking user preferences over time; new approaches for modeling people's behavior in situations that involve music; and the design of agents capable of meaningful interaction with humans and other agents in a setting where music plays a roll (either directly or indirectly). Though motivated primarily by music-related tasks, and focusing largely on people's musical preferences, this thesis also establishes that insights from music-specific case studies can also be applicable in other concrete social domains, such as different types of content recommendation. Showing the generality of insights from musical data in other contexts serves as evidence for the utility of music domains as testbeds for the development of general artificial intelligence techniques. Ultimately, this thesis demonstrates the overall usefulness of taking a sequential decision making approach in settings previously unexplored from this perspectiveComputer Science

epiCaPture: a urine DNA methylation test for early detection of aggressive prostate cancer

Purpose Liquid biopsies that noninvasively detect molecular correlates of aggressive prostate cancer (PCa) could be used to triage patients, reducing the burdens of unnecessary invasive prostate biopsy and enabling early detection of high-risk disease. DNA hypermethylation is among the earliest and most frequent aberrations in PCa. We investigated the accuracy of a six-gene DNA methylation panel (Epigenetic Cancer of the Prostate Test in Urine [epiCaPture]) at detecting PCa, high-grade (Gleason score greater than or equal to 8) and high-risk (D'Amico and Cancer of the Prostate Risk Assessment] PCa from urine. Patients and Methods Prognostic utility of epiCaPture genes was first validated in two independent prostate tissue cohorts. epiCaPture was assessed in a multicenter prospective study of 463 men undergoing prostate biopsy. epiCaPture was performed by quantitative methylation-specific polymerase chain reaction in DNA isolated from prebiopsy urine sediments and evaluated by receiver operating characteristic and decision curves (clinical benefit). The epiCaPture score was developed and validated on a two thirds training set to one third test set. Results Higher methylation of epiCaPture genes was significantly associated with increasing aggressiveness in PCa tissues. In urine, area under the receiver operating characteristic curve was 0.64, 0.86, and 0.83 for detecting PCa, high-grade PCa, and highrisk PCa, respectively. Decision curves revealed a net benefit across relevant threshold probabilities. Independent analysis of two epiCaPture genes in the same clinical cohort provided analytical validation. Parallel epiCaPture analysis in urine and matched biopsy cores showed added value of a liquid biopsy. Conclusion epiCaPture is a urine DNA methylation test for high-risk PCa. Its tumor specificity out-performs that of prostate-specific antigen (greater than 3 ng/mL). Used as an adjunct to prostate-specific antigen, epiCaPture could aid patient stratification to determine need for biopsy