In-vivo magnetic resonance imaging of hyperpolarized silicon particles

Silicon-based micro and nanoparticles have gained popularity in a wide range of biomedical applications due to their biocompatibility and biodegradability in-vivo, as well as a flexible surface chemistry, which allows drug loading, functionalization and targeting. Here we report direct in-vivo imaging of hyperpolarized 29Si nuclei in silicon microparticles by MRI. Natural physical properties of silicon provide surface electronic states for dynamic nuclear polarization (DNP), extremely long depolarization times, insensitivity to the in-vivo environment or particle tumbling, and surfaces favorable for functionalization. Potential applications to gastrointestinal, intravascular, and tumor perfusion imaging at sub-picomolar concentrations are presented. These results demonstrate a new background-free imaging modality applicable to a range of inexpensive, readily available, and biocompatible Si particles.Comment: Supplemental Material include

Determination of the detective quantum efficiency of a prototype, megavoltage indirect detection, active matrix flatâ panel imager

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134773/1/mp3516.pd

Segmented crystalline scintillators: An initial investigation of high quantum efficiency detectors for megavoltage xâ ray imaging

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134936/1/mp8407.pd

LSST: from Science Drivers to Reference Design and Anticipated Data Products

(Abridged) We describe here the most ambitious survey currently planned in the optical, the Large Synoptic Survey Telescope (LSST). A vast array of science will be enabled by a single wide-deep-fast sky survey, and LSST will have unique survey capability in the faint time domain. The LSST design is driven by four main science themes: probing dark energy and dark matter, taking an inventory of the Solar System, exploring the transient optical sky, and mapping the Milky Way. LSST will be a wide-field ground-based system sited at Cerro Pach\'{o}n in northern Chile. The telescope will have an 8.4 m (6.5 m effective) primary mirror, a 9.6 deg$^2$ field of view, and a 3.2 Gigapixel camera. The standard observing sequence will consist of pairs of 15-second exposures in a given field, with two such visits in each pointing in a given night. With these repeats, the LSST system is capable of imaging about 10,000 square degrees of sky in a single filter in three nights. The typical 5$\sigma$ point-source depth in a single visit in $r$ will be $\sim 24.5$ (AB). The project is in the construction phase and will begin regular survey operations by 2022. The survey area will be contained within 30,000 deg$^2$ with $\delta<+34.5^\circ$, and will be imaged multiple times in six bands, $ugrizy$, covering the wavelength range 320--1050 nm. About 90\% of the observing time will be devoted to a deep-wide-fast survey mode which will uniformly observe a 18,000 deg$^2$ region about 800 times (summed over all six bands) during the anticipated 10 years of operations, and yield a coadded map to $r\sim27.5$. The remaining 10\% of the observing time will be allocated to projects such as a Very Deep and Fast time domain survey. The goal is to make LSST data products, including a relational database of about 32 trillion observations of 40 billion objects, available to the public and scientists around the world.Comment: 57 pages, 32 color figures, version with high-resolution figures available from https://www.lsst.org/overvie

Monte Carlo investigations of the effect of beam divergence on thick, segmented crystalline scintillators for radiotherapy imaging

The use of thick, segmented scintillators in electronic portal imagers offers the potential for significant improvement in x-ray detection efficiency compared to conventional phosphor screens. Such improvement substantially increases the detective quantum efficiency (DQE), leading to the possibility of achieving soft-tissue visualization at clinically practical (i.e. low) doses using megavoltage (MV) cone-beam computed tomography. While these DQE increases are greatest at zero spatial frequency, they are diminished at higher frequencies as a result of degradation of spatial resolution due to lateral spreading of secondary radiation within the scintillator—an effect that is more pronounced for thicker scintillators. The extent of this spreading is even more accentuated for radiation impinging the scintillator at oblique angles of incidence due to beam divergence. In this paper, Monte Carlo simulations of radiation transport, performed to investigate and quantify the effects of beam divergence on the imaging performance of MV imagers based on two promising scintillators (BGO and CsI:Tl), are reported. In these studies, 10–40 mm thick scintillators, incorporating low-density polymer, or high-density tungsten septal walls, were examined for incident angles corresponding to that encountered at locations up to ~15 cm from the central beam axis (for an imager located 130 cm from a radiotherapy x-ray source). The simulations demonstrate progressively more severe spatial resolution degradation (quantified in terms of the effect on the modulation transfer function) as a function of increasing angle of incidence (as well as of the scintillator thickness). Since the noise power behavior was found to be largely independent of the incident angle, the dependence of the DQE on the incident angle is therefore primarily determined by the spatial resolution. The observed DQE degradation suggests that 10 mm thick scintillators are not strongly affected by beam divergence for detector areas up to ~30 × 30 cm2. For thicker scintillators, the area that is relatively unaffected is significantly reduced, requiring a focused scintillator geometry in order to preserve spatial resolution, and thus DQE.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/85404/1/pmb10_13_006.pd

Theoretical investigation of the design and performance of a dual energy (kV and MV) radiotherapy imager

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134977/1/mp5120.pd