Characterizing Cardiac Electrophysiology during Radiofrequency Ablation : An Integrative Ex vivo, In silico, and In vivo Approach

Catheter ablation is a major treatment for atrial tachycardias. Hereby, the precise monitoring of the lesion formation is an important success factor. This book presents computational, wet-lab, and clinical studies with the aim of evaluating the signal characteristics of the intracardiac electrograms (IEGMs) recorded around ablation lesions from different perspectives. The detailed analysis of the IEGMs can optimize the description of durable and complex lesions during the ablation procedure

Proceedings of the First International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics

1st International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Kruger Park, 8-10 April 2002.This lecture is a principle-based review of a growing body of fundamental work stimulated by multiple opportunities to optimize geometric form (shape, structure, configuration, rhythm, topology, architecture, geography) in systems for heat and fluid flow. Currents flow against resistances, and by generating entropy (irreversibility) they force the system global performance to levels lower than the theoretical limit. The system design is destined to remain imperfect because of constraints (finite sizes, costs, times). Improvements can be achieved by properly balancing the resistances, i.e., by spreading the imperfections through the system. Optimal spreading means to endow the system with geometric form. The system construction springs out of the constrained maximization of global performance. This 'constructal' design principle is reviewed by highlighting applications from heat transfer engineering. Several examples illustrate the optimized internal structure of convection cooled packages of electronics. The origin of optimal geometric features lies in the global effort to use every volume element to the maximum, i.e., to pack the element not only with the most heat generating components, but also with the most flow, in such a way that every fluid packet is effectively engaged in cooling. In flows that connect a point to a volume or an area, the resulting structure is a tree with high conductivity branches and low-conductivity interstices.tm201