26,246 research outputs found
Disease Progression Mediated by Egr-1 Associated Signaling in Response to Oxidative Stress
When cellular reducing enzymes fail to shield the cell from increased amounts of reactive oxygen species (ROS), oxidative stress arises. The redox state is misbalanced, DNA and proteins are damaged and cellular transcription networks are activated. This condition can lead to the initiation and/or to the progression of atherosclerosis, tumors or pulmonary hypertension; diseases that are decisively furthered by the presence of oxidizing agents. Redox sensitive genes, like the zinc finger transcription factor early growth response 1 (Egr-1), play a pivotal role in the pathophysiology of these diseases. Apart from inducing apoptosis, signaling partners like the MEK/ERK pathway or the protein kinase C (PKC) can activate salvage programs such as cell proliferation that do not ameliorate, but rather worsen their outcome. Here, we review the currently available data on Egr-1 related signal transduction cascades in response to oxidative stress in the progression of epidemiologically significant diseases. Knowing the molecular pathways behind the pathology will greatly enhance our ability to identify possible targets for the development of new therapeutic strategies
A multi-paradigm language for reactive synthesis
This paper proposes a language for describing reactive synthesis problems
that integrates imperative and declarative elements. The semantics is defined
in terms of two-player turn-based infinite games with full information.
Currently, synthesis tools accept linear temporal logic (LTL) as input, but
this description is less structured and does not facilitate the expression of
sequential constraints. This motivates the use of a structured programming
language to specify synthesis problems. Transition systems and guarded commands
serve as imperative constructs, expressed in a syntax based on that of the
modeling language Promela. The syntax allows defining which player controls
data and control flow, and separating a program into assumptions and
guarantees. These notions are necessary for input to game solvers. The
integration of imperative and declarative paradigms allows using the paradigm
that is most appropriate for expressing each requirement. The declarative part
is expressed in the LTL fragment of generalized reactivity(1), which admits
efficient synthesis algorithms, extended with past LTL. The implementation
translates Promela to input for the Slugs synthesizer and is written in Python.
The AMBA AHB bus case study is revisited and synthesized efficiently,
identifying the need to reorder binary decision diagrams during strategy
construction, in order to prevent the exponential blowup observed in previous
work.Comment: In Proceedings SYNT 2015, arXiv:1602.0078
Aerospace medicine and biology: A continuing bibliography with indexes (supplement 355)
This bibliography lists 147 reports, articles and other documents introduced into the NASA Scientific and Technical Information System during October, 1991. Subject coverage includes: aerospace medicine and psychology, life support systems and controlled environments, safety equipment, exobiology and extraterrestrial life, and flight crew behavior and performance
A Conceptual Framework for Adapation
This paper presents a white-box conceptual framework for adaptation that promotes a neat separation of the adaptation logic from the application logic through a clear identification of control data and their role in the adaptation logic. The framework provides an original perspective from which we survey archetypal approaches to (self-)adaptation ranging from programming languages and paradigms, to computational models, to engineering solutions
A Conceptual Framework for Adapation
This paper presents a white-box conceptual framework for adaptation that promotes a neat separation of the adaptation logic from the application logic through a clear identification of control data and their role in the adaptation logic. The framework provides an original perspective from which we survey archetypal approaches to (self-)adaptation ranging from programming languages and paradigms, to computational models, to engineering solutions
A Conceptual Framework for Adapation
We present a white-box conceptual framework for adaptation. We called it CODA, for COntrol Data Adaptation, since it is based on the notion of control data. CODA promotes a neat separation between application and adaptation logic through a clear identification of the set of data that is relevant for the latter. The framework provides an original perspective from which we survey a representative set of approaches to adaptation ranging from programming languages and paradigms, to computational models and architectural solutions
Recommended from our members
BioScript: programming safe chemistry on laboratories-on-a-chip
This paper introduces BioScript, a domain-specific language (DSL) for programmable biochemistry which executes on emerging microfluidic platforms. The goal of this research is to provide a simple, intuitive, and type-safe DSL that is accessible to life science practitioners. The novel feature of the language is its syntax, which aims to optimize human readability; the technical contributions of the paper include the BioScript type system and relevant portions of its compiler. The type system ensures that certain types of errors, specific to biochemistry, do not occur, including the interaction of chemicals that may be unsafe. The compiler includes novel optimizations that place biochemical operations to execute concurrently on a spatial 2D array platform on the granularity of a control flow graph, as opposed to individual basic blocks. Results are obtained using both a cycle-accurate microfluidic simulator and a software interface to a real-world platform
- …