Backpropagation Neural Network Based on Local Search Strategy and Enhanced Multi-objective Evolutionary Algorithm for Breast Cancer Diagnosis

The role of intelligence techniques is becoming more significant in detecting and diagnosis of medical data. However, the performance of such methods is based on the algorithms or technique. In this paper, we develop an intelligent technique using multiobjective evolutionary method hybrid with a local search approach to enhance the backpropagation neural network. First, we enhance the famous multiobjective evolutionary algorithms, which is a non-dominated sorting genetic algorithm (NSGA-II). Then, we hybrid the enhanced algorithm with the local search strategy to ensures the acceleration of the convergence speed to the non-dominated front. In addition, such hybridization get the solutions achieved are well spread over it. As a result of using a local search method the quality of the Pareto optimal solutions are increased and all individuals in the population are enhanced. The key notion of the proposed algorithm was to  show a new technique to settle automaticly artificial neural network design problem. The empirical results generated by the proposed intelligent technique evaluated by applying to the breast cancer dataset and emphasize the capability of the proposed algorithm to improve the results. The network size and accuracy results of the proposed method are better than the previous methods. Therefore, the method is then capable of finding a proper number of hidden neurons and error rates of the BP algorithm

An Optimized Recursive General Regression Neural Network Oracle for the Prediction and Diagnosis of Diabetes

Diabetes is a serious, chronic disease that has been seeing a rise in the number of cases and prevalence over the past few decades. It can lead to serious complications and can increase the overall risk of dying prematurely. Data-oriented prediction models have become effective tools that help medical decision-making and diagnoses in which the use of machine learning in medicine has increased substantially. This research introduces the Recursive General Regression Neural Network Oracle (R-GRNN Oracle) and is applied on the Pima Indians Diabetes dataset for the prediction and diagnosis of diabetes. The R-GRNN Oracle (Bani-Hani, 2017) is an enhancement to the GRNN Oracle developed by Masters et al. in 1998, in which the recursive model is created of two oracles: one within the other. Several classifiers, along with the R-GRNN Oracle and the GRNN Oracle, are applied to the dataset, they are: Support Vector Machine (SVM), Multilayer Perceptron (MLP), Probabilistic Neural Network (PNN), Gaussian NaEF;ve Bayes (GNB), K-Nearest Neighbor (KNN), and Random Forest (RF). Genetic Algorithm (GA) was used for feature selection as well as the hyperparameter optimization of SVM and MLP, and Grid Search (GS) was used to optimize the hyperparameters of KNN and RF. The performance metrics accuracy, AUC, sensitivity, and specificity were recorded for each classifier. The R-GRNN Oracle was able to achieve the highest accuracy, AUC, and sensitivity (81.14%, 86.03%, and 63.80%, respectively), while the optimized MLP had the highest specificity (89.71%)

Radial Basis Function Neural Networks : A Review

Radial Basis Function neural networks (RBFNNs) represent an attractive alternative to other neural network models. One reason is that they form a unifying link between function approximation, regularization, noisy interpolation, classification and density estimation. It is also the case that training RBF neural networks is faster than training multi-layer perceptron networks. RBFNN learning is usually split into an unsupervised part, where center and widths of the Gaussian basis functions are set, and a linear supervised part for weight computation. This paper reviews various learning methods for determining centers, widths, and synaptic weights of RBFNN. In addition, we will point to some applications of RBFNN in various fields. In the end, we name software that can be used for implementing RBFNNs

Backpropagation neural network based on local search strategy and enhanced multi-objective evolutionary algorithm for breast cancer diagnosis

The role of intelligence techniques is becoming more significant in detecting and diagnosis of medical data. However, the performance of such methods is based on the algorithms or technique. In this paper, we develop an intelligent technique using multiobjective evolutionary method hybrid with a local search approach to enhance the backpropagation neural network. First, we enhance the famous multiobjective evolutionary algorithms, which is a non-dominated sorting genetic algorithm (NSGA-II). Then, we hybrid the enhanced algorithm with the local search strategy to ensures the acceleration of the convergence speed to the non-dominated front. In addition, such hybridization get the solutions achieved are well spread over it. As a result of using a local search method the quality of the Pareto optimal solutions are increased and all individuals in the population are enhanced. The key notion of the proposed algorithm was to show a new technique to settle automaticly artificial neural network design problem. The empirical results generated by the proposed intelligent technique evaluated by applying to the breast cancer dataset and emphasize the capability of the proposed algorithm to improve the results. The network size and accuracy results of the proposed method are better than the previous methods. Therefore, the method is then capable of finding a proper number of hidden neurons and error rates of the BP algorithm

Computational models and approaches for lung cancer diagnosis

The success of treatment of patients with cancer depends on establishing an accurate diagnosis. To this end, the aim of this study is to developed novel lung cancer diagnostic models. New algorithms are proposed to analyse the biological data and extract knowledge that assists in achieving accurate diagnosis results

Automated characterization of Tumor-Infiltrating Lymphocytes (TIL) in histological breast images

Cancer illness has a big influence on society. Its extended proliferation and high aggressiveness make it a difficult problem to solve and therefore a big deal for science. Recently, a research trend has been focusing on how 3D tumor structure affects the development of the cancer and its outcome, especially metastasis. Stromal structure and tumor cell signaling are processes that highly influence tumor migration. Thus, histological analysis becomes a fundamental tool to study tumor structure, which provides valuable information about cell characteristics and organization. The relevance of histological study is supported by the increasing interest of anatomopathologists to have good automatic solutions to support the specialist’s diagnosis. For this purpose, the current thesis proposes an automated approach to analyze hematoxylin and eosin (H&E) stained histological images, particularly coming from breast cancer patients. The proposed method consists on the classification of the nuclei in H&E-stained histological images and the further analysis of tumor-infiltrating lymphocytes (TIL) present on the visualized section. The starting point of the approach is the automatic nuclei-segmented binary mask. Each of the segmented nuclei is classified into two types, cancerous or healthy. The classification is performed by a trained artificial neural network to give two binary masks, each of them containing one type of nuclei. Then, the algorithm can follow two different paths: classification of zones or TIL analysis. Classification of zones has the aim to provide a more comfortable support to perform cancer diagnosis, because it provides quantitative information of tumor lobule size. To achieve it, a nuclei correction step is executed, by which each nucleus class depends on the area surrounding it. In this way, a clearer vision of the existing zones is provided (tumor lobule or tumor microenvironment). The other approach is to perform TIL analysis. This technique is based on the nuclei classified binary masks and analyzes the immune system response against the tumor. This way, healthy cells of tumor microenvironment are detected and quantified. The ratio of TIL occupied area to free microenvironment area is computed as informational parameter. This ratio is calculated by the combination of a manually-segmented zone binary mask and the nuclei classified binary mask. In this way, only healthy nuclei of microenvironment zone are considered, dividing the sum of their area by the free sections of the microenvironment zone (i.e. area of microenvironment zone where nuclei are not present). Moreover, the TIL dispersion factor is computed to study their distribution throughout the area by dividing the microenvironment area in several zones and calculate the standard deviation of the area of lymphocytes within each of them. Afterward, the opposed of standard deviation is computed to obtain the dispersion factor. Automatic results are found to match the gold standard (the pathologist’s diagnosis), although some error is observed after evaluation. The approach taken in this work has a positive outlook, even though some aspects need to be polished, like the algorithm accuracy and the use of a larger set of images to claim a proper functionality for global cases.Ingeniería Biomédic

Data mining applied to the cognitive rehabilitation of patients with acquired brain injury

Acquired brain injury (ABI) is one of the leading causes of death and disability in the world and is associated with high health care costs as a result of the acute treatment and long term rehabilitation involved. Different algorithms and methods have been proposed to predict the effectiveness of rehabilitation programs. In general, research has focused on predicting the overall improvement of patients with ABI. The purpose of this study is the novel application of data mining (DM) techniques to predict the outcomes of cognitive rehabilitation in patients with ABI. We generate three predictive models that allow us to obtain new knowledge to evaluate and improve the effectiveness of the cognitive rehabilitation process. Decision tree (DT), multilayer perceptron (MLP) and general regression neural network (GRNN) have been used to construct the prediction models. 10-fold cross validation was carried out in order to test the algorithms, using the Institut Guttmann Neurorehabilitation Hospital (IG) patients database. Performance of the models was tested through specificity, sensitivity and accuracy analysis and confusion matrix analysis. The experimental results obtained by DT are clearly superior with a prediction average accuracy of 90.38%, while MLP and GRRN obtained a 78.7% and 75.96%, respectively. This study allows to increase the knowledge about the contributing factors of an ABI patient recovery and to estimate treatment efficacy in individual patients

A survey on artificial intelligence based techniques for diagnosis of hepatitis variants

Hepatitis is a dreaded disease that has taken the lives of so many people over the recent past years. The research survey shows that hepatitis viral disease has five major variants referred to as Hepatitis A, B, C, D, and E. Scholars over the years have tried to find an alternative diagnostic means for hepatitis disease using artificial intelligence (AI) techniques in order to save lives. This study extensively reviewed 37 papers on AI based techniques for diagnosing core hepatitis viral disease. Results showed that Hepatitis B (30%) and C (3%) were the only types of hepatitis the AI-based techniques were used to diagnose and properly classified out of the five major types, while (67%) of the paper reviewed diagnosed hepatitis disease based on the different AI based approach but were not classified into any of the five major types. Results from the study also revealed that 18 out of the 37 papers reviewed used hybrid approach, while the remaining 19 used single AI based approach. This shows no significance in terms of technique usage in modeling intelligence into application. This study reveals furthermore a serious gap in knowledge in terms of single hepatitis type prediction or diagnosis in all the papers considered, and recommends that the future road map should be in the aspect of integrating the major hepatitis variants into a single predictive model using effective intelligent machine learning techniques in order to reduce cost of diagnosis and quick treatment of patients

Automatic detection and classification of leukaemia cells

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Today, there is a substantial number of software and research groups that focus on the development of image processing software to extract useful information from medical images, in order to assist and improve patient diagnosis. The work presented in this thesis is centred on processing of images of blood and bone marrow smears of patients suffering from leukaemia, a common type of cancer. In general, cancer is due to aberrant gene expression, which is caused by either mutations or epigenetic changes in DNA. Poor diet and unhealthy lifestyle may trigger or contribute to these changes, although the underlying mechanism is often unknown. Importantly, many cancer types including leukaemia are curable and patient survival and treatment can be improved, subject to prompt diagnosis. In particular, this study focuses on Acute Myeloid Leukaemia (AML), which can be of eight distinct types (M0 to M7), with the main objective to develop a methodology to automatically detect and classify leukaemia cells into one of the above types. The data was collected from the Department of Haematology, Universiti Sains Malaysia, in Malaysia. Three main methods, namely Cellular Automata, Heuristic Search and classification using Neural Networks are facilitated. In the case of Cellular Automata, an improved method based on the 8-neighbourhood and rules were developed to remove noise from images and estimate the radius of the potential blast cells contained in them. The proposed methodology selects the starting points, corresponding to potential blast cells, for the subsequent seeded heuristic search. The Seeded Heuristic employs a new fitness function for blast cell detection. Furthermore, the WEKA software is utilised for classification of blast cells and hence images, into AML subtypes. As a result accuracy of 97.22% was achieved in the classification of blasts into M3 and other AML subtypes. Finally, these algorithms are integrated into an automated system for image processing. In brief, the research presented in this thesis involves the use of advanced computational techniques for processing and classification of medical images, that is, images of blood samples from patients suffering from leukaemia.The Institute of Higher Education of Malaysia and the Universiti Sains Islam Malaysia (USIM)