6,444 research outputs found
A Methodology for Discovering how to Adaptively Personalize to Users using Experimental Comparisons
We explain and provide examples of a formalism that supports the methodology
of discovering how to adapt and personalize technology by combining randomized
experiments with variables associated with user models. We characterize a
formal relationship between the use of technology to conduct A/B experiments
and use of technology for adaptive personalization. The MOOClet Formalism [11]
captures the equivalence between experimentation and personalization in its
conceptualization of modular components of a technology. This motivates a
unified software design pattern that enables technology components that can be
compared in an experiment to also be adapted based on contextual data, or
personalized based on user characteristics. With the aid of a concrete use
case, we illustrate the potential of the MOOClet formalism for a methodology
that uses randomized experiments of alternative micro-designs to discover how
to adapt technology based on user characteristics, and then dynamically
implements these personalized improvements in real time
Business Process Innovation using the Process Innovation Laboratory
Most organizations today are required not only to establish effective business processes but they are required to accommodate for changing business conditions at an increasing rate. Many business processes extend beyond the boundary of the enterprise into the supply chain and the information infrastructure therefore is critical. Today nearly every business relies on their Enterprise System (ES) for process integration and the future generations of enterprise systems will increasingly be driven by business process models. Consequently process modeling and improvement will become vital for business process innovation (BPI) in future organizations. There is a significant body of knowledge on various aspect of process innovation, e.g. on conceptual modeling, business processes, supply chains and enterprise systems. Still an overall comprehensive and consistent theoretical framework with guidelines for practical applications has not been identified. The aim of this paper is to establish a conceptual framework for business process innovation in the supply chain based on advanced enterprise systems. The main approach to business process innovation in this context is to create a new methodology for exploring process models and patterns of applications. The paper thus presents a new concept for business process innovation called the process innovation laboratory a.k.a. the Ð-Lab. The Ð-Lab is a comprehensive framework for BPI using advanced enterprise systems. The Ð-Lab is a collaborative workspace for experimenting with process models and an explorative approach to study integrated modeling in a controlled environment. The Ð-Lab facilitates innovation by using an integrated action learning approach to process modeling including contemporary technological, organizational and business perspectivesNo; keywords
Research and Development Workstation Environment: the new class of Current Research Information Systems
Against the backdrop of the development of modern technologies in the field
of scientific research the new class of Current Research Information Systems
(CRIS) and related intelligent information technologies has arisen. It was
called - Research and Development Workstation Environment (RDWE) - the
comprehensive problem-oriented information systems for scientific research and
development lifecycle support. The given paper describes design and development
fundamentals of the RDWE class systems. The RDWE class system's generalized
information model is represented in the article as a three-tuple composite web
service that include: a set of atomic web services, each of them can be
designed and developed as a microservice or a desktop application, that allows
them to be used as an independent software separately; a set of functions, the
functional filling-up of the Research and Development Workstation Environment;
a subset of atomic web services that are required to implement function of
composite web service. In accordance with the fundamental information model of
the RDWE class the system for supporting research in the field of ontology
engineering - the automated building of applied ontology in an arbitrary domain
area, scientific and technical creativity - the automated preparation of
application documents for patenting inventions in Ukraine was developed. It was
called - Personal Research Information System. A distinctive feature of such
systems is the possibility of their problematic orientation to various types of
scientific activities by combining on a variety of functional services and
adding new ones within the cloud integrated environment. The main results of
our work are focused on enhancing the effectiveness of the scientist's research
and development lifecycle in the arbitrary domain area.Comment: In English, 13 pages, 1 figure, 1 table, added references in Russian.
Published. Prepared for special issue (UkrPROG 2018 conference) of the
scientific journal "Problems of programming" (Founder: National Academy of
Sciences of Ukraine, Institute of Software Systems of NAS Ukraine
Space Biosciences Division
In the Space Biosciences Division at NASA's Ames Research Center, we perform the biological research and technology development necessary to tackle the challenges of living in the extreme environments of space and to enable NASA's long-term human exploration mission. This brochure provides a broad overview for our research and development capabilities, several case study examples, and finally real-world applications and collaborative partnerships
A Scientific Roadmap for Antibiotic Discovery: A Sustained and Robust Pipeline of New Antibacterial Drugs and Therapies is Critical to Preserve Public Health
In recent decades, the discovery and development of new antibiotics have slowed dramatically as scientific barriers to drug discovery, regulatory challenges, and diminishing returns on investment have led major drug companies to scale back or abandon their antibiotic research. Consequently, antibiotic discovery—which peaked in the 1950s—has dropped precipitously. Of greater concern is the fact that nearly all antibiotics brought to market over the past 30 years have been variations on existing drugs. Every currently available antibiotic is a derivative of a class discovered between the early 1900s and 1984.At the same time, the emergence of antibiotic-resistant pathogens has accelerated, giving rise to life-threatening infections that will not respond to available antibiotic treatment. Inevitably, the more that antibiotics are used, the more that bacteria develop resistance—rendering the drugs less effective and leading public health authorities worldwide to flag antibiotic resistance as an urgent and growing public health threat
Career: hybrid surfaces to control cell adhesion and function
Issued as final reportNational Science Foundation (U.S.
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