Bio-realistic Neural Network Implementation on Loihi 2 with Izhikevich Neurons

In this paper, we presented a bio-realistic basal ganglia neural network and its integration into Intel's Loihi neuromorphic processor to perform simple Go/No-Go task. To incorporate more bio-realistic and diverse set of neuron dynamics, we used Izhikevich neuron model, implemented as microcode, instead of Leaky-Integrate and Fire (LIF) neuron model that has built-in support on Loihi. This work aims to demonstrate the feasibility of implementing computationally efficient custom neuron models on Loihi for building spiking neural networks (SNNs) that features these custom neurons to realize bio-realistic neural networks

From Parallel Sequence Representations to Calligraphic Control: A Conspiracy of Neural Circuits

Calligraphic writing presents a rich set of challenges to the human movement control system. These challenges include: initial learning, and recall from memory, of prescribed stroke sequences; critical timing of stroke onsets and durations; fine control of grip and contact forces; and letter-form invariance under voluntary size scaling, which entails fine control of stroke direction and amplitude during recruitment and derecruitment of musculoskeletal degrees of freedom. Experimental and computational studies in behavioral neuroscience have made rapid progress toward explaining the learning, planning and contTOl exercised in tasks that share features with calligraphic writing and drawing. This article summarizes computational neuroscience models and related neurobiological data that reveal critical operations spanning from parallel sequence representations to fine force control. Part one addresses stroke sequencing. It treats competitive queuing (CQ) models of sequence representation, performance, learning, and recall. Part two addresses letter size scaling and motor equivalence. It treats cursive handwriting models together with models in which sensory-motor tmnsformations are performed by circuits that learn inverse differential kinematic mappings. Part three addresses fine-grained control of timing and transient forces, by treating circuit models that learn to solve inverse dynamics problems.National Institutes of Health (R01 DC02852

Virtual deep brain stimulation: Multiscale co-simulation of a spiking basal ganglia model and a whole-brain mean-field model with The Virtual Brain

Deep brain stimulation (DBS) has been successfully applied in various neurodegenerative diseases as an effective symptomatic treatment. However, its mechanisms of action within the brain network are still poorly understood. Many virtual DBS models analyze a subnetwork around the basal ganglia and its dynamics as a spiking network with their details validated by experimental data. However, connectomic evidence shows widespread effects of DBS affecting many different cortical and subcortical areas. From a clinical perspective, various effects of DBS besides the motoric impact have been demonstrated. The neuroinformatics platform The Virtual Brain (TVB) offers a modeling framework allowing us to virtually perform stimulation, including DBS, and forecast the outcome from a dynamic systems perspective prior to invasive surgery with DBS lead placement. For an accurate prediction of the effects of DBS, we implement a detailed spiking model of the basal ganglia, which we combine with TVB via our previously developed co-simulation environment. This multiscale co-simulation approach builds on the extensive previous literature of spiking models of the basal ganglia while simultaneously offering a whole-brain perspective on widespread effects of the stimulation going beyond the motor circuit. In the first demonstration of our model, we show that virtual DBS can move the firing rates of a Parkinson's disease patient's thalamus - basal ganglia network towards the healthy regime while, at the same time, altering the activity in distributed cortical regions with a pronounced effect in frontal regions. Thus, we provide proof of concept for virtual DBS in a co-simulation environment with TVB. The developed modeling approach has the potential to optimize DBS lead placement and configuration and forecast the success of DBS treatment for individual patients

Adaptive networks for robotics and the emergence of reward anticipatory circuits

Currently the central challenge facing evolutionary robotics is to determine how best to extend the range and complexity of behaviour supported by evolved neural systems. Implicit in the work described in this thesis is the idea that this might best be achieved through devising neural circuits (tractable to evolutionary exploration) that exhibit complementary functional characteristics. We concentrate on two problem domains; locomotion and sequence learning. For locomotion we compare the use of GasNets and other adaptive networks. For sequence learning we introduce a novel connectionist model inspired by the role of dopamine in the basal ganglia (commonly interpreted as a form of reinforcement learning). This connectionist approach relies upon a new neuron model inspired by notions of energy efficient signalling. Two reward adaptive circuit variants were investigated. These were applied respectively to two learning problems; where action sequences are required to take place in a strict order, and secondly, where action sequences are robust to intermediate arbitrary states. We conclude the thesis by proposing a formal model of functional integration, encompassing locomotion and sequence learning, extending ideas proposed by W. Ross Ashby. A general model of the adaptive replicator is presented, incoporating subsystems that are tuned to continuous variation and discrete or conditional events. Comparisons are made with Ross W. Ashby's model of ultrastability and his ideas on adaptive behaviour. This model is intended to support our assertion that, GasNets (and similar networks) and reward adaptive circuits of the type presented here, are intrinsically complementary. In conclusion we present some ideas on how the co-evolution of GasNet and reward adaptive circuits might lead us to significant improvements in the synthesis of agents capable of exhibiting complex adaptive behaviour

An investigation into motor pools and their applicability to a biologically inspired model of ballistic voluntary motor action

This study investigates the properties of motor pools in the human motor control system. The simulations carried out as part of this study used two biologically inspired neuronal models to simulate networks with properties similar to those observed in the human motor system (Burke, 1991). The Synchronous neuronal model developed as part of this study explicitly models the input/output spike train and frequency relationship of each neuron. The motor pool simulations were carried out using the INSIGHT TOO simulation software developed as part of this study. INSIGHT TOO is a flexible neural design tool that allows the visual interactive design of network connectivity and has the power of a node specification language similar to that of BASIC that allows multi-layer, multi-model networks to be simulated. The simulations have shown that the motor pools are capable of reproducing commonly observed physiological properties during normal voluntary reaching movements. As a result of these findings a theoretical model of ballistic voluntary motor action was proposed called the Recruitment Model. The Recruitment model utilises the "recruitment" principle known to exist in motor pools and applies this distributed processing methodology to the higher levels of motor action to explain how complex structures similar to the human skeletal system might be controlled. A simple version of the Recruitment Model is simulated showing an animation of a running "stick man". This simulation demonstrates some of the principles necessary to solve problems relating to synergy formation