56,076 research outputs found
Flexible Session Management in a Distributed Environment
Many secure communication libraries used by distributed systems, such as SSL,
TLS, and Kerberos, fail to make a clear distinction between the authentication,
session, and communication layers. In this paper we introduce CEDAR, the secure
communication library used by the Condor High Throughput Computing software,
and present the advantages to a distributed computing system resulting from
CEDAR's separation of these layers. Regardless of the authentication method
used, CEDAR establishes a secure session key, which has the flexibility to be
used for multiple capabilities. We demonstrate how a layered approach to
security sessions can avoid round-trips and latency inherent in network
authentication. The creation of a distinct session management layer allows for
optimizations to improve scalability by way of delegating sessions to other
components in the system. This session delegation creates a chain of trust that
reduces the overhead of establishing secure connections and enables centralized
enforcement of system-wide security policies. Additionally, secure channels
based upon UDP datagrams are often overlooked by existing libraries; we show
how CEDAR's structure accommodates this as well. As an example of the utility
of this work, we show how the use of delegated security sessions and other
techniques inherent in CEDAR's architecture enables US CMS to meet their
scalability requirements in deploying Condor over large-scale, wide-area grid
systems
Preliminary basic performance analysis of the Cedar multiprocessor memory system
Some preliminary basic results on the performance of the Cedar multiprocessor memory system are presented. Empirical results are presented and used to calibrate a memory system simulator which is then used to discuss the scalability of the system
Practical Evaluation of Lempel-Ziv-78 and Lempel-Ziv-Welch Tries
We present the first thorough practical study of the Lempel-Ziv-78 and the
Lempel-Ziv-Welch computation based on trie data structures. With a careful
selection of trie representations we can beat well-tuned popular trie data
structures like Judy, m-Bonsai or Cedar
Evaluation of the Cedar memory system: Configuration of 16 by 16
Some basic results on the performance of the Cedar multiprocessor system are presented. Empirical results on the 16 processor 16 memory bank system configuration, which show the behavior of the Cedar system under different modes of operation are presented
CEDAR: tools for event generator tuning
I describe the work of the CEDAR collaboration in developing tools for tuning
and validating Monte Carlo event generator programs. The core CEDAR task is to
interface the Durham HepData database of experimental measurements to event
generator validation tools such as the UCL JetWeb system - this has
necessitated the migration of HepData to a new relational database system and a
Java-based interaction model. The "number crunching" part of JetWeb is also
being upgraded, from the Fortran HZTool library to the new C++ Rivet system and
a generator interfacing layer named RivetGun. Finally, I describe how Rivet is
already being used as a central part of a new generator tuning system, and
summarise two other CEDAR activities, HepML and HepForge.Comment: 13 pages, prepared for XI International Workshop on Advanced
Computing and Analysis Techniques in Physics Research, Amsterdam, April 23-27
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Design of testbed and emulation tools
The research summarized was concerned with the design of testbed and emulation tools suitable to assist in projecting, with reasonable accuracy, the expected performance of highly concurrent computing systems on large, complete applications. Such testbed and emulation tools are intended for the eventual use of those exploring new concurrent system architectures and organizations, either as users or as designers of such systems. While a range of alternatives was considered, a software based set of hierarchical tools was chosen to provide maximum flexibility, to ease in moving to new computers as technology improves and to take advantage of the inherent reliability and availability of commercially available computing systems
Parallel machine architecture and compiler design facilities
The objective is to provide an integrated simulation environment for studying and evaluating various issues in designing parallel systems, including machine architectures, parallelizing compiler techniques, and parallel algorithms. The status of Delta project (which objective is to provide a facility to allow rapid prototyping of parallelized compilers that can target toward different machine architectures) is summarized. Included are the surveys of the program manipulation tools developed, the environmental software supporting Delta, and the compiler research projects in which Delta has played a role
A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization
Background
Endothelial dysfunction (ED) is functionally characterized by decreased vasorelaxation, increased thrombosis, increased inflammation, and altered angiogenic potential, has been intimately associated with the progression and severity of cardiovascular disease. Patients with compromised cardiac function oftentimes have a state of chronic mild decreased oxygen at the level of the vasculature and organs, which has been shown to exacerbate ED. Hypoxia inducible factor (HIF) is a transcription factor complex shown to be the master regulator of the cellular response to decreased oxygen levels and many HIF target genes have been shown to be associated with ED.
Methods
Human endothelial and aortic smooth muscle cells were exposed either to A) normoxia (21% O2) for three weeks, or to B) mild decreased oxygen (15% O2) for three weeks to mimic blood oxygen levels in patients with heart failure, or to C) mild decreased oxygen for two weeks followed by one week of normoxia ("memory" treatment). Levels of HIF signaling genes (HIF-1α, HIF-2α, VEGF, BNIP3, GLUT-1, PAI-1 and iNOS) were measured both at the protein and mRNA levels.
Results
It was found that chronic exposure to mild decreased oxygen resulted in significantly increased HIF signaling. There was also a "memory" of HIF-1α and HIF target gene induction when oxygen levels were normalized for one week, and this "memory" could be interrupted by adding a small molecule HIF inhibitor to the last week of normalized oxygen. Finally, levels of ubiquitylated HIF-1α were reduced in response to chronic mild decreased oxygen and were not full restored after oxygen normalization.
Conclusion
These data suggest that HIF signaling may be contributing to the pathogenesis of endothelial dysfunction and that normalization of oxygen levels may not be enough to reduce vascular stress
Inside Magazine, March 2010
Iowa Department of Transportation Newsletter. INSIDE Magazine is developed to help keep all Iowa DOT employees informed about critical issues affecting them, recognize DOT employees for their excellent service and share interesting aspects in the lives of our co-workers
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