Innovative in silico approaches to address avian flu using grid technology

The recent years have seen the emergence of diseases which have spread very quickly all around the world either through human travels like SARS or animal migration like avian flu. Among the biggest challenges raised by infectious emerging diseases, one is related to the constant mutation of the viruses which turns them into continuously moving targets for drug and vaccine discovery. Another challenge is related to the early detection and surveillance of the diseases as new cases can appear just anywhere due to the globalization of exchanges and the circulation of people and animals around the earth, as recently demonstrated by the avian flu epidemics. For 3 years now, a collaboration of teams in Europe and Asia has been exploring some innovative in silico approaches to better tackle avian flu taking advantage of the very large computing resources available on international grid infrastructures. Grids were used to study the impact of mutations on the effectiveness of existing drugs against H5N1 and to find potentially new leads active on mutated strains. Grids allow also the integration of distributed data in a completely secured way. The paper presents how we are currently exploring how to integrate the existing data sources towards a global surveillance network for molecular epidemiology.Comment: 7 pages, submitted to Infectious Disorders - Drug Target

Asynchronous Remote Medical Consultation for Ghana

Computer-mediated communication systems can be used to bridge the gap between doctors in underserved regions with local shortages of medical expertise and medical specialists worldwide. To this end, we describe the design of a prototype remote consultation system intended to provide the social, institutional and infrastructural context for sustained, self-organizing growth of a globally-distributed Ghanaian medical community. The design is grounded in an iterative design process that included two rounds of extended design fieldwork throughout Ghana and draws on three key design principles (social networks as a framework on which to build incentives within a self-organizing network; optional and incremental integration with existing referral mechanisms; and a weakly-connected, distributed architecture that allows for a highly interactive, responsive system despite failures in connectivity). We discuss initial experiences from an ongoing trial deployment in southern Ghana.Comment: 10 page

Grid Databases for Shared Image Analysis in the MammoGrid Project

The MammoGrid project aims to prove that Grid infrastructures can be used for collaborative clinical analysis of database-resident but geographically distributed medical images. This requires: a) the provision of a clinician-facing front-end workstation and b) the ability to service real-world clinician queries across a distributed and federated database. The MammoGrid project will prove the viability of the Grid by harnessing its power to enable radiologists from geographically dispersed hospitals to share standardized mammograms, to compare diagnoses (with and without computer aided detection of tumours) and to perform sophisticated epidemiological studies across national boundaries. This paper outlines the approach taken in MammoGrid to seamlessly connect radiologist workstations across a Grid using an "information infrastructure" and a DICOM-compliant object model residing in multiple distributed data stores in Italy and the UKComment: 10 pages, 5 figure

Real-world Machine Learning Systems: A survey from a Data-Oriented Architecture Perspective

Machine Learning models are being deployed as parts of real-world systems with the upsurge of interest in artificial intelligence. The design, implementation, and maintenance of such systems are challenged by real-world environments that produce larger amounts of heterogeneous data and users requiring increasingly faster responses with efficient resource consumption. These requirements push prevalent software architectures to the limit when deploying ML-based systems. Data-oriented Architecture (DOA) is an emerging concept that equips systems better for integrating ML models. DOA extends current architectures to create data-driven, loosely coupled, decentralised, open systems. Even though papers on deployed ML-based systems do not mention DOA, their authors made design decisions that implicitly follow DOA. The reasons why, how, and the extent to which DOA is adopted in these systems are unclear. Implicit design decisions limit the practitioners' knowledge of DOA to design ML-based systems in the real world. This paper answers these questions by surveying real-world deployments of ML-based systems. The survey shows the design decisions of the systems and the requirements these satisfy. Based on the survey findings, we also formulate practical advice to facilitate the deployment of ML-based systems. Finally, we outline open challenges to deploying DOA-based systems that integrate ML models.Comment: Under revie