4,001 research outputs found
Approaches to the use of sensor data to improve classroom experience
quipping classrooms with inexpensive sensors can enable students and teachers with the opportunity to interact with the classroom in a smart way. In this paper an approach to acquiring contextual data from a classroom environment, using inexpensive sensors, is presented. We present our approach to formalising the usage data. Further we demonstrate how the data was used to model specific room usage situation as cases in a Case-based reasoning (CBR) system. The room usage data was than integrated in a room recommendations system, reasoning on the formalised usage data. We also detail on our on-going work to integrating the systems presented in this paper into our Smart University vision
Data literacy in the smart university approach
Equipping classrooms with inexpensive sensors for data collection can provide students and teachers with the opportunity to interact with the classroom in a smart way. In this paper two approaches to acquiring contextual data from a classroom environment are presented. We further present our approach to analysing the collected room usage data on site, using low cost single board computer, such as a Raspberry Pi and Arduino units, performing a significant part of the data analysis on-site. We demonstrate how the usage data was used to model specifcic room usage situation as cases in a Case-based reasoning (CBR) system. The room usage data was then integrated in a room recommender system, reasoning on the formalised usage data, allowing for a convenient and intuitive end user experience based on the collected raw sensor data. Having implemented and tested our approaches we are currently investigating the possibility of using (XML)Schema-informed compression to enhance the security and efficiency of the transmission of a large number of sensor reports generated by interpreting the raw data on-site, to our central data sink. We are investigating this new approach to usage data transmission as we are aiming to integrate our on-going work into our vision of the Smart University to ensure and enhance the Smart University's data literacy
A novel mode of capping protein-regulation by Twinfilin
Cellular actin assembly is controlled at the barbed ends of actin filaments, where capping protein (CP) limits polymerization. Twinfilin is a conserved in vivo binding partner of CP, yet the significance of this interaction has remained a mystery. Here, we discover that the C-terminal tail of Twinfilin harbors a CP-interacting (CPI) motif, identifying it as a novel CPI-motif protein. Twinfilin and the CPI-motif protein CARMIL have overlapping binding sites on CP. Further, Twinfilin binds competitively with CARMIL to CP, protecting CP from barbed-end displacement by CARMIL. Twinfilin also accelerates dissociation of the CP inhibitor V-1, restoring CP to an active capping state. Knockdowns of Twinfilin and CP each cause similar defects in cell morphology, and elevated Twinfilin expression rescues defects caused by CARMIL hyperactivity. Together, these observations define Twinfilin as the first \u27pro-capping\u27 ligand of CP and lead us to propose important revisions to our understanding of the CP regulatory cycle
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A VLSI implementation of the collision avoidance switch protocol for CAMB tree LANs
To solve a performance bottle neck in random access LANs due to packet collisions and their resolution, collision avoidance switches are introduced. These switches allow random access protocols to achieve high performance by resolving collisions among packets. A conventional hardware implementation of these switches is the use of TTL chips. In this implementation; a handful of TTL chips are required to forma single switch (e.g., 18 TTL chips are needed for an implementation of the CAMB switch [7]). Thus, implementation of a complete network, which requires several of these switches, could very well result in a large and complex hardware system.Today's modern chip technology allows us to pack large quantity of logic in a single chip. By transferring the conventional implementation of the collision avoidance switches into a VLSI chip, the complexity of the resultant hardware is greatly reduced, not to mention the improvement in hardware performance and ease of packaging.This report provides an overall study of the collision avoidance protocols for the tree LANs with emphasis on the implementation of collision avoidance switches. Hardware implementations of sorne of these switches are discussed. And a VLSI implementation of the CAMB switch protocol is introduced
The Custodial Randall-Sundrum Model: From Precision Tests to Higgs Physics
We reexamine the Randall-Sundrum (RS) model with enlarged gauge symmetry
SU(2)_L x SU(2)_R x U(1)_X x P_LR in the presence of a brane-localized Higgs
sector. In contrast to the existing literature, we perform the Kaluza-Klein
(KK) decomposition within the mass basis, which avoids the truncation of the KK
towers. Expanding the low-energy spectrum as well as the gauge couplings in
powers of the Higgs vacuum expectation value, we obtain analytic formulas which
allow for a deep understanding of the model-specific protection mechanisms of
the T parameter and the left-handed Z-boson couplings. In particular, in the
latter case we explain which contributions escape protection and identify them
with the irreducible sources of P_LR symmetry breaking. We furthermore show
explicitly that no protection mechanism is present in the charged-current
sector confirming existing model-independent findings. The main focus of the
phenomenological part of our work is a detailed discussion of Higgs-boson
couplings and their impact on physics at the CERN Large Hadron Collider. For
the first time, a complete one-loop calculation of all relevant Higgs-boson
production and decay channels is presented, incorporating the effects stemming
from the extended electroweak gauge-boson and fermion sectors.Comment: 74 pages, 13 figures, 3 tables. v2: Matches version published in JHE
Technology News, October-December 2014
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State-of-charge and state-of-health prediction of lead-acid batteries for hybrid electric vehicles using non-linear observers
The paper describes the application of state-estimation techniques for the real-time prediction of state-of-charge (SoC) and state-of-health (SoH) of lead-acid cells. Approaches based on the extended Kalman filter (EKF) are presented to provide correction for offset, drift and state divergence - an unfortunate feature of more traditional coulomb-counting techniques. Experimental results are employed to demonstrate the relative attributes of the proposed methodolog
Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response.
The progressive failure of protein homeostasis is a hallmark of aging and a common feature in neurodegenerative disease. As the enzymes executing the final stages of autophagy, lysosomal proteases are key contributors to the maintenance of protein homeostasis with age. We previously reported that expression of granulin peptides, the cleavage products of the neurodegenerative disease protein progranulin, enhance the accumulation and toxicity of TAR DNA binding protein 43 (TDP-43) in Caenorhabditis elegans (C. elegans). In this study we show that C. elegans granulins are produced in an age- and stress-dependent manner. Granulins localize to the endolysosomal compartment where they impair lysosomal protease expression and activity. Consequently, protein homeostasis is disrupted, promoting the nuclear translocation of the lysosomal transcription factor HLH-30/TFEB, and prompting cells to activate a compensatory transcriptional program. The three C. elegans granulin peptides exhibited distinct but overlapping functional effects in our assays, which may be due to amino acid composition that results in distinct electrostatic and hydrophobicity profiles. Our results support a model in which granulin production modulates a critical transition between the normal, physiological regulation of protease activity and the impairment of lysosomal function that can occur with age and disease
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