39,862 research outputs found
DPVis: Visual Analytics with Hidden Markov Models for Disease Progression Pathways
Clinical researchers use disease progression models to understand patient
status and characterize progression patterns from longitudinal health records.
One approach for disease progression modeling is to describe patient status
using a small number of states that represent distinctive distributions over a
set of observed measures. Hidden Markov models (HMMs) and its variants are a
class of models that both discover these states and make inferences of health
states for patients. Despite the advantages of using the algorithms for
discovering interesting patterns, it still remains challenging for medical
experts to interpret model outputs, understand complex modeling parameters, and
clinically make sense of the patterns. To tackle these problems, we conducted a
design study with clinical scientists, statisticians, and visualization
experts, with the goal to investigate disease progression pathways of chronic
diseases, namely type 1 diabetes (T1D), Huntington's disease, Parkinson's
disease, and chronic obstructive pulmonary disease (COPD). As a result, we
introduce DPVis which seamlessly integrates model parameters and outcomes of
HMMs into interpretable and interactive visualizations. In this study, we
demonstrate that DPVis is successful in evaluating disease progression models,
visually summarizing disease states, interactively exploring disease
progression patterns, and building, analyzing, and comparing clinically
relevant patient subgroups.Comment: to appear at IEEE Transactions on Visualization and Computer Graphic
Discovery Is Never By Chance: Designing for (Un)Serendipity
Serendipity has a long tradition in the history of science as having played a key role in many significant discoveries. Computer scientists, valuing the role of serendipity in discovery, have attempted to design systems that encourage serendipity. However, that research has focused primarily on only one aspect of serendipity: that of chance encounters. In reality, for serendipity to be valuable chance encounters must be synthesized into insight. In this paper we show, through a formal consideration of serendipity and analysis of how various systems have seized on attributes of interpreting serendipity, that there is a richer space for design to support serendipitous creativity, innovation and discovery than has been tapped to date. We discuss how ideas might be encoded to be shared or discovered by ‘association-hunting’ agents. We propose considering not only the inventor’s role in perceiving serendipity, but also how that inventor’s perception may be enhanced to increase the opportunity for serendipity. We explore the role of environment and how we can better enable serendipitous discoveries to find a home more readily and immediately
- …