Prognostic Tools for Early Mortality in Hemorrhagic Stroke: Systematic Review and Meta-Analysis

Background and Purpose: Several risk scores have been developed to predict mortality in intracerebral hemorrhage (ICH). We aimed to systematically determine the performance of published prognostic tools. Methods: We searched MEDLINE and EMBASE for prognostic models (published between 2004 and April 2014) used in predicting early mortality (<6 months) after ICH. We evaluated the discrimination performance of the tools through a random-effects meta-analysis of the area under the receiver operating characteristic curve (AUC) or c-statistic. We evaluated the following components of the study validity: study design, collection of prognostic variables, treatment pathways, and missing data. Results: We identified 11 articles (involving 41,555 patients) reporting on the accuracy of 12 different tools for predicting mortality in ICH. Most studies were either retrospective or post-hoc analyses of prospectively collected data; all but one produced validation data. The Hemphill-ICH score had the largest number of validation cohorts (9 studies involving 3,819 patients) within our systematic review and showed good performance in 4 countries, with a pooled AUC of 0.80 [95% confidence interval (CI)=0.77-0.85]. We identified several modified versions of the Hemphill-ICH score, with the ICH-Grading Scale (GS) score appearing to be the most promising variant, with a pooled AUC across four studies of 0.87 (95% CI=0.84-0.90). Subgroup testing found statistically significant differences between the AUCs obtained in studies involving Hemphill-ICH and ICH-GS scores (p=0.01). Conclusions: Our meta-analysis evaluated the performance of 12 ICH prognostic tools and found greater supporting evidence for 2 models (Hemphill-ICH and ICH-GS), with generally good performance overall

Approaches to conceptual clustering

Methods for Conceptual Clustering may be explicated in two lights. Conceptual Clustering methods may be viewed as extensions to techniques of numerical taxonomy, a collection of methods developed by social and natural scientists for creating classification schemes over object sets. Alternatively, conceptual clustering may be viewed as a form of learning by observation or concept formation, as opposed to methods of learning from examples or concept identification. In this paper we survey and compare a number of conceptual clustering methods along dimensions suggested by each of these views. The point we most wish to clarify is that conceptual clustering processes can be explicated as being composed of three distinct but inter-dependent subprocesses: the process of deriving a hierarchical classification scheme; the process of aggregating objects into individual classes; and the process of assigning conceptual descriptions to object classes. Each subprocess may be characterized along a number of dimensions related to search, thus facilitating a better understanding of the conceptual clustering process as a whole

Coordinate noun phrase disambiguation in a generative parsing model

In this paper we present methods for improving the disambiguation of noun phrase (NP) coordination within the framework of a lexicalised history-based parsing model. As well as reducing noise in the data, we look at modelling two main sources of information for disambiguation: symmetry in conjunct structure, and the dependency between conjunct lexical heads. Our changes to the baseline model result in an increase in NP coordination dependency f-score from 69.9% to 73.8%, which represents a relative reduction in f-score error of 13%