Deep Grassmann Manifold Optimization for Computer Vision

In this work, we propose methods that advance four areas in the field of computer vision: dimensionality reduction, deep feature embeddings, visual domain adaptation, and deep neural network compression. We combine concepts from the fields of manifold geometry and deep learning to develop cutting edge methods in each of these areas. Each of the methods proposed in this work achieves state-of-the-art results in our experiments. We propose the Proxy Matrix Optimization (PMO) method for optimization over orthogonal matrix manifolds, such as the Grassmann manifold. This optimization technique is designed to be highly flexible enabling it to be leveraged in many situations where traditional manifold optimization methods cannot be used. We first use PMO in the field of dimensionality reduction, where we propose an iterative optimization approach to Principal Component Analysis (PCA) in a framework called Proxy Matrix optimization based PCA (PM-PCA). We also demonstrate how PM-PCA can be used to solve the general $L_p$-PCA problem, a variant of PCA that uses arbitrary fractional norms, which can be more robust to outliers. We then present Cascaded Projection (CaP), a method which uses tensor compression based on PMO, to reduce the number of filters in deep neural networks. This, in turn, reduces the number of computational operations required to process each image with the network. Cascaded Projection is the first end-to-end trainable method for network compression that uses standard backpropagation to learn the optimal tensor compression. In the area of deep feature embeddings, we introduce Deep Euclidean Feature Representations through Adaptation on the Grassmann manifold (DEFRAG), that leverages PMO. The DEFRAG method improves the feature embeddings learned by deep neural networks through the use of auxiliary loss functions and Grassmann manifold optimization. Lastly, in the area of visual domain adaptation, we propose the Manifold-Aligned Label Transfer for Domain Adaptation (MALT-DA) to transfer knowledge from samples in a known domain to an unknown domain based on cross-domain cluster correspondences

Generative-Discriminative Low Rank Decomposition for Medical Imaging Applications

In this thesis, we propose a method that can be used to extract biomarkers from medical images toward early diagnosis of abnormalities. Surge of demand for biomarkers and availability of medical images in the recent years call for accurate, repeatable, and interpretable approaches for extracting meaningful imaging features. However, extracting such information from medical images is a challenging task because the number of pixels (voxels) in a typical image is in order of millions while even a large sample-size in medical image dataset does not usually exceed a few hundred. Nevertheless, depending on the nature of an abnormality, only a parsimonious subset of voxels is typically relevant to the disease; therefore various notions of sparsity are exploited in this thesis to improve the generalization performance of the prediction task. We propose a novel discriminative dimensionality reduction method that yields good classification performance on various datasets without compromising the clinical interpretability of the results. This is achieved by combining the modelling strength of generative learning framework and the classification performance of discriminative learning paradigm. Clinical interpretability can be viewed as an additional measure of evaluation and is also helpful in designing methods that account for the clinical prior such as association of certain areas in a brain to a particular cognitive task or connectivity of some brain regions via neural fibres. We formulate our method as a large-scale optimization problem to solve a constrained matrix factorization. Finding an optimal solution of the large-scale matrix factorization renders off-the-shelf solver computationally prohibitive; therefore, we designed an efficient algorithm based on the proximal method to address the computational bottle-neck of the optimization problem. Our formulation is readily extended for different scenarios such as cases where a large cohort of subjects has uncertain or no class labels (semi-supervised learning) or a case where each subject has a battery of imaging channels (multi-channel), \etc. We show that by using various notions of sparsity as feasible sets of the optimization problem, we can encode different forms of prior knowledge ranging from brain parcellation to brain connectivity