Computer-assisted polyp matching between optical colonoscopy and CT colonography: a phantom study

Potentially precancerous polyps detected with CT colonography (CTC) need to be removed subsequently, using an optical colonoscope (OC). Due to large colonic deformations induced by the colonoscope, even very experienced colonoscopists find it difficult to pinpoint the exact location of the colonoscope tip in relation to polyps reported on CTC. This can cause unduly prolonged OC examinations that are stressful for the patient, colonoscopist and supporting staff. We developed a method, based on monocular 3D reconstruction from OC images, that automatically matches polyps observed in OC with polyps reported on prior CTC. A matching cost is computed, using rigid point-based registration between surface point clouds extracted from both modalities. A 3D printed and painted phantom of a 25 cm long transverse colon segment was used to validate the method on two medium sized polyps. Results indicate that the matching cost is smaller at the correct corresponding polyp between OC and CTC: the value is 3.9 times higher at the incorrect polyp, comparing the correct match between polyps to the incorrect match. Furthermore, we evaluate the matching of the reconstructed polyp from OC with other colonic endoluminal surface structures such as haustral folds and show that there is a minimum at the correct polyp from CTC. Automated matching between polyps observed at OC and prior CTC would facilitate the biopsy or removal of true-positive pathology or exclusion of false-positive CTC findings, and would reduce colonoscopy false-negative (missed) polyps. Ultimately, such a method might reduce healthcare costs, patient inconvenience and discomfort.Comment: This paper was presented at the SPIE Medical Imaging 2014 conferenc

Visual / acoustic detection and localisation in embedded systems

©Cranfield UniversityThe continuous miniaturisation of sensing and processing technologies is increasingly offering a variety of embedded platforms, enabling the accomplishment of a broad range of tasks using such systems. Motivated by these advances, this thesis investigates embedded detection and localisation solutions using vision and acoustic sensors. Focus is particularly placed on surveillance applications using sensor networks. Existing vision-based detection solutions for embedded systems suffer from the sensitivity to environmental conditions. In the literature, there seems to be no algorithm able to simultaneously tackle all the challenges inherent to real-world videos. Regarding the acoustic modality, many research works have investigated acoustic source localisation solutions in distributed sensor networks. Nevertheless, it is still a challenging task to develop an ecient algorithm that deals with the experimental issues, to approach the performance required by these systems and to perform the data processing in a distributed and robust manner. The movement of scene objects is generally accompanied with sound emissions with features that vary from an environment to another. Therefore, considering the combination of the visual and acoustic modalities would offer a significant opportunity for improving the detection and/or localisation using the described platforms. In the light of the described framework, we investigate in the first part of the thesis the use of a cost-effective visual based method that can deal robustly with the issue of motion detection in static, dynamic and moving background conditions. For motion detection in static and dynamic backgrounds, we present the development and the performance analysis of a spatio- temporal form of the Gaussian mixture model. On the other hand, the problem of motion detection in moving backgrounds is addressed by accounting for registration errors in the captured images. By adopting a robust optimisation technique that takes into account the uncertainty about the visual measurements, we show that high detection accuracy can be achieved. In the second part of this thesis, we investigate solutions to the problem of acoustic source localisation using a trust region based optimisation technique. The proposed method shows an overall higher accuracy and convergence improvement compared to a linear-search based method. More importantly, we show that through characterising the errors in measurements, which is a common problem for such platforms, higher accuracy in the localisation can be attained. The last part of this work studies the different possibilities of combining visual and acoustic information in a distributed sensors network. In this context, we first propose to include the acoustic information in the visual model. The obtained new augmented model provides promising improvements in the detection and localisation processes. The second investigated solution consists in the fusion of the measurements coming from the different sensors. An evaluation of the accuracy of localisation and tracking using a centralised/decentralised architecture is conducted in various scenarios and experimental conditions. Results have shown the capability of this fusion approach to yield higher accuracy in the localisation and tracking of an active acoustic source than by using a single type of data

Medical-Data-Models.org:A collection of freely available forms (September 2016)

MDM-Portal (Medical Data-Models) is a meta-data repository for creating, analysing, sharing and reusing medical forms, developed by the Institute of Medical Informatics, University of Muenster in Germany. Electronic forms for documentation of patient data are an integral part within the workflow of physicians. A huge amount of data is collected either through routine documentation forms (EHRs) for electronic health records or as case report forms (CRFs) for clinical trials. This raises major scientific challenges for health care, since different health information systems are not necessarily compatible with each other and thus information exchange of structured data is hampered. Software vendors provide a variety of individual documentation forms according to their standard contracts, which function as isolated applications. Furthermore, free availability of those forms is rarely the case. Currently less than 5 % of medical forms are freely accessible. Based on this lack of transparency harmonization of data models in health care is extremely cumbersome, thus work and know-how of completed clinical trials and routine documentation in hospitals are hard to be re-used. The MDM-Portal serves as an infrastructure for academic (non-commercial) medical research to contribute a solution to this problem. It already contains more than 4,000 system-independent forms (CDISC ODM Format, www.cdisc.org, Operational Data Model) with more than 380,000 dataelements. This enables researchers to view, discuss, download and export forms in most common technical formats such as PDF, CSV, Excel, SQL, SPSS, R, etc. A growing user community will lead to a growing database of medical forms. In this matter, we would like to encourage all medical researchers to register and add forms and discuss existing forms