Modelling Cell Cycle using Different Levels of Representation

Understanding the behaviour of biological systems requires a complex setting of in vitro and in vivo experiments, which attracts high costs in terms of time and resources. The use of mathematical models allows researchers to perform computerised simulations of biological systems, which are called in silico experiments, to attain important insights and predictions about the system behaviour with a considerably lower cost. Computer visualisation is an important part of this approach, since it provides a realistic representation of the system behaviour. We define a formal methodology to model biological systems using different levels of representation: a purely formal representation, which we call molecular level, models the biochemical dynamics of the system; visualisation-oriented representations, which we call visual levels, provide views of the biological system at a higher level of organisation and are equipped with the necessary spatial information to generate the appropriate visualisation. We choose Spatial CLS, a formal language belonging to the class of Calculi of Looping Sequences, as the formalism for modelling all representation levels. We illustrate our approach using the budding yeast cell cycle as a case study

Event-Related Potentials and Emotion Processing in Child Psychopathology

In recent years there has been increasing interest in the neural mechanisms underlying altered emotional processes in children and adolescents with psychopathology. This review provides a brief overview of the most up-to-date findings in the field of Event-Related Potentials (ERPs) to facial and vocal emotional expressions in the most common child psychopathological conditions. In regards to externalising behaviour (i.e. ADHD, CD), ERP studies show enhanced early components to anger, reflecting enhanced sensory processing, followed by reductions in later components to anger, reflecting reduced cognitive-evaluative processing. In regards to internalising behaviour, research supports models of increased processing of threat stimuli especially at later more elaborate and effortful stages. Finally, in autism spectrum disorders abnormalities have been observed at early visual-perceptual stages of processing. An affective neuroscience framework for understanding child psychopathology can be valuable in elucidating underlying mechanisms and inform preventive intervention

Changes in navigational behaviour produced by a wide field of view and a high fidelity visual scene

The difficulties people frequently have navigating in virtual environments (VEs) are well known. Usually these difficulties are quantified in terms of performance (e.g., time taken or number of errors made in following a path), with these data used to compare navigation in VEs to equivalent real-world settings. However, an important cause of any performance differences is changes in people’s navigational behaviour. This paper reports a study that investigated the effect of visual scene fidelity and field of view (FOV) on participants’ behaviour in a navigational search task, to help identify the thresholds of fidelity that are required for efficient VE navigation. With a wide FOV (144 degrees), participants spent significantly larger proportion of their time travelling through the VE, whereas participants who used a normal FOV (48 degrees) spent significantly longer standing in one place planning where to travel. Also, participants who used a wide FOV and a high fidelity scene came significantly closer to conducting the search "perfectly" (visiting each place once). In an earlier real-world study, participants completed 93% of their searches perfectly and planned where to travel while they moved. Thus, navigating a high fidelity VE with a wide FOV increased the similarity between VE and real-world navigational behaviour, which has important implications for both VE design and understanding human navigation. Detailed analysis of the errors that participants made during their non-perfect searches highlighted a dramatic difference between the two FOVs. With a narrow FOV participants often travelled right past a target without it appearing on the display, whereas with the wide FOV targets that were displayed towards the sides of participants overall FOV were often not searched, indicating a problem with the demands made by such a wide FOV display on human visual attention

A procedure for evaluating the influence of road context on drivers' visual behaviour

In this paper, we investigated drivers' visual behaviour while travelling a road regularly opened to traffic in order to evaluate the effectiveness of the traditional scientific models and propose, at the same time, further measures useful for understanding the complex phenomenon. As is known, drivers acquire the necessary information for knowing the road geometry by visually detecting certain areas of the surrounding context. Some models in the literature have shown in a simple and convincing way these mechanisms, but they are valid only with specific assumptions, often very restrictive, such as a two-lane road, horizontal sign clearly visible and no interaction with other vehicles. For this reason, in this study we wanted to investigate different conditions, by estimating the visual strategy of some regular drivers on a three-lane road in presence of other vehicles. The visual behaviour was surveyed with the Tobii Glasses Eye Tracker and the resulting raw data were further manipulated by us to extract more useful information for our purposes. In particular, we quantified the driver's dedicated attention to the various elements present inside the environmental context, both static (road edges, road signs, dashboard, etc.) and dynamic (other vehicles), meaning by this term those that could potentially collide with the trajectories of our vehicle. The achieved results, highlighting the limits of validity of some recent studies, contain some proposed indexes useful to give a better understanding of the visual behaviour in order to detect any eventual weakness of the road