13,705 research outputs found
Erwin Schroedinger, Francis Crick and epigenetic stability
Schroedinger's book 'What is Life?' is widely credited for having played a
crucial role in development of molecular and cellular biology. My essay
revisits the issues raised by this book from the modern perspective of
epigenetics and systems biology. I contrast two classes of potential mechanisms
of epigenetic stability: 'epigenetic templating' and 'systems biology'
approaches, and consider them from the point of view expressed by Schroedinger.
I also discuss how quantum entanglement, a nonclassical feature of quantum
mechanics, can help to address the 'problem of small numbers' that lead
Schroedinger to promote the idea of molecular code-script for explanation of
stability of biological order.Comment: New and improved version of the essay, now published in the online
journal 'Biology Direct'. Contains more expanded discussion on entanglement.
18 pages, 2 figures. The file includes open reviews by E.Koonin, V.Vedral and
E.Karsent
A state variable for crumpled thin sheets
Despite the apparent ease with which a sheet of paper is crumpled and tossed
away, crumpling dynamics are often considered a paradigm of complexity. This
complexity arises from the infinite number of configurations a disordered
crumpled sheet can take. Here we experimentally show that key aspects of
crumpling have a very simple description; the evolution of the damage in
crumpling dynamics can largely be described by a single global quantity, the
total length of all creases. We follow the evolution of the damage network in
repetitively crumpled elastoplastic sheets, and show that the dynamics of this
quantity are deterministic, and depend only on the instantaneous state of the
crease network and not at all on the crumpling history. We also show that this
global quantity captures the crumpling dynamics of a sheet crumpled for the
first time. This leads to a remarkable reduction in complexity, allowing a
description of a highly disordered system by a single state parameter. Similar
strategies may also be useful in analyzing other systems that evolve under
geometric and mechanical constraints, from faulting of tectonic plates to the
evolution of proteins
Open problems in artificial life
This article lists fourteen open problems in artificial life, each of which is a grand challenge requiring a major advance on a fundamental issue for its solution. Each problem is briefly explained, and, where deemed helpful, some promising paths to its solution are indicated
The mechanical response of semiflexible networks to localized perturbations
Previous research on semiflexible polymers including cytoskeletal networks in
cells has suggested the existence of distinct regimes of elastic response, in
which the strain field is either uniform (affine) or non-uniform (non-affine)
under external stress. Associated with these regimes, it has been further
suggested that a new fundamental length scale emerges, which characterizes the
scale for the crossover from non-affine to affine deformations. Here, we extend
these studies by probing the response to localized forces and force dipoles. We
show that the previously identified nonaffinity length [D.A. Head et al. PRE
68, 061907 (2003).] controls the mesoscopic response to point forces and the
crossover to continuum elastic behavior at large distances.Comment: 16 pages, 18 figures; substantial changes to text and figures to
clarify the crossover to continuum elasticity and the role of finite-size
effect
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