PHARMACEUTICAL SCHEDULING USING SIMULATED ANNEALING AND STEEPEST DESCENT METHOD

In the pharmaceutical manufacturing world, a deadline could be the difference between losing a multimillion-dollar contract or extending it. This, among many other reasons, is why good scheduling methods are vital. This problem report addresses Flexible Flowshop (FF) scheduling using Simulated Annealing (SA) in conjunction with the Steepest Descent heuristic (SD). FF is a generalized version of the flowshop problem, where each product goes through S number of stages, where each stage has M number of machines. As opposed to a normal flowshop problem, all ‘jobs’ do not have to flow in the same sequence from stage to stage. The SA metaheuristic is a global optimization method for solving hard combinatorial optimization problems. SD is a local search method that keeps track only of the current solution and moves only to neighboring permutations based on the largest decrease in the objective function value. The goal of this problem report is to use FF in conjunction with SA to minimize the makespan (length of schedule) in a pharmaceutical manufacturing environment. There are 4 total stages in the tentative production route: granulation, compression, coating, and packaging. This process will be uniform; as in, each stage will have the same number of identical machines. In this study, SA solved the illustrative small-scale example problems precisely and efficiently using a very small amount of computation time. Afterward, the SD heuristic is used to ensure that the best solution found by SA is a local optimum. SD did not improve upon the solutions found by SA

َA Multi-objective simulated annealing algorithm to solving flexible no-wait flowshop scheduling problems with transportation times

This paper deals with a bi-objective hybrid no-wait flowshop scheduling problem minimizing the makespan and total weighted tardiness, in which we consider transportation times between stages. Obtaining an optimal solution for this type of complex, large-sized problem in reasonable computational time by using traditional approaches and optimization tools is extremely difficult. This paper presents a new multi-objective simulated annealing algorithm (MOSA). A set of experimental instances are carried out to evaluate the algorithm by advanced multi-objective performance measures. The algorithm is carefully evaluated for its performance against available algorithm by means of multi-objective performance measures and statistical tools. The related results show that a variant of our proposed MOSA provides sound performance comparing with other algorithms

Theoretical and Computational Research in Various Scheduling Models

Nine manuscripts were published in this Special Issue on “Theoretical and Computational Research in Various Scheduling Models, 2021” of the MDPI Mathematics journal, covering a wide range of topics connected to the theory and applications of various scheduling models and their extensions/generalizations. These topics include a road network maintenance project, cost reduction of the subcontracted resources, a variant of the relocation problem, a network of activities with generally distributed durations through a Markov chain, idea on how to improve the return loading rate problem by integrating the sub-tour reversal approach with the method of the theory of constraints, an extended solution method for optimizing the bi-objective no-idle permutation flowshop scheduling problem, the burn-in (B/I) procedure, the Pareto-scheduling problem with two competing agents, and three preemptive Pareto-scheduling problems with two competing agents, among others. We hope that the book will be of interest to those working in the area of various scheduling problems and provide a bridge to facilitate the interaction between researchers and practitioners in scheduling questions. Although discrete mathematics is a common method to solve scheduling problems, the further development of this method is limited due to the lack of general principles, which poses a major challenge in this research field

The hybrid flexible flowshop with transportation times

This paper presents the hybrid, flexible flowshop problem with transportation times between stages, which is an extension of an existing scheduling problem that is well-studied in the literature. We explore different models for the problem with Constraint Programming, MILP, and local search, and compare them on generated benchmark problems that reflect the problem of the industrial partner. We then study two different factory layout design problems, and use the optimization tool to understand the impact of the design choices on the solution quality

Production Scheduling

Generally speaking, scheduling is the procedure of mapping a set of tasks or jobs (studied objects) to a set of target resources efficiently. More specifically, as a part of a larger planning and scheduling process, production scheduling is essential for the proper functioning of a manufacturing enterprise. This book presents ten chapters divided into five sections. Section 1 discusses rescheduling strategies, policies, and methods for production scheduling. Section 2 presents two chapters about flow shop scheduling. Section 3 describes heuristic and metaheuristic methods for treating the scheduling problem in an efficient manner. In addition, two test cases are presented in Section 4. The first uses simulation, while the second shows a real implementation of a production scheduling system. Finally, Section 5 presents some modeling strategies for building production scheduling systems. This book will be of interest to those working in the decision-making branches of production, in various operational research areas, as well as computational methods design. People from a diverse background ranging from academia and research to those working in industry, can take advantage of this volume

Minimizing the sum of flow times with batching and delivery in a supply chain

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The aim of this thesis is to study one of the classical scheduling objectives that is of minimizing the sum of flow times, in the context of a supply chain network. We consider the situation that a supplier schedules a set of jobs for delivery in batches to several manufacturers, who in tum have to schedule and deliver jobs in batches to several customers. The individual problem from the viewpoint of supplier and manufacturers will be considered separately. The decision problem faced by the supplier is that of minimizing the sum of flow time and delivery cost of a set of jobs to be processed on a single machine for delivery in batches to manufacturers. The problem from the viewpoint of manufacturer is similar to the supplier's problem and the only difference is that the scheduling, batching and delivery decisions made by the supplier define a release date for each job, before which the manufacturer cannot start the processing of that job. Also a combined problem in the light of cooperation between the supplier and manufacturer will be considered. The objective of the combined problem is to find the best scheduling, batching, and delivery decisions that benefit the entire system including the supplier and manufacturer. Structural properties of each problem are investigated and used to devise a branch and bound solution scheme. Computational experience shows significant improvements over existing algorithms and also shows that cooperation between a supplier and a manufacturer reduces the total system cost of up to 12.35%, while theoretically the reduction of up to 20% can be achieved for special cases

Performance Improvement Through Benchmarking for Small and Medium Manufacturers (SMM)

Die wichtigsten Kostenfaktoren innerhalb einer Lieferkette lassen sich drei Kategorien zuordnen: Produktions-, Transport-und Lagerkosten. Die Strukturen dieser operativen Kosten im Hinblick auf die Gesamtkosten variieren stark je nach Industriesektor. Produktionskosten stellen dennoch die höchste Kostenart in fast allen Branchen dar, weniger bedeutend folgen danach jeweils die Transport- und Lagerkosten. Die Optimierung einer dieser Kategorien ohne Rücksicht auf die anderen kann zur Erhöhung der Gesamtkosten sowie der allgemeinen Leistungsfähigkeit führen. Diese Dissertation befasst sich mit dem „production distribution problem“ wobei synchronisierte Strategien entwickelt werden können, um die Leistung der Supply Chain zu verbessern und gleichzeitig die Gesamtkosten zu minimieren. Dazu wurde eine Fallstudie aus der Realität untersucht, nämlich das Praxisbeispiel eines Herstellers von Waschmitteln. Zwei Hauptszenarien werden bewertet. Das erste Szenario ist der konventionelle Plan, wobei die Hersteller dominieren. Dies bedeutet, dass der Hersteller findet seinen eigenen optimalen Job-Scheduling-Plan, während die Distribution versucht mit Hilfe dessen ihren optimalen Plan zu finden. Dadurch erhöhen sich die Distributionskosten. Das zweite Szenario betrifft die Synchronisation der Produktions-, Lagerhaltungs- und Transportzeitpläne. Ein zu diesem Zweck entwickeltes Java-Programm und die Job-Scheduling-Software Simal wurden für die Modellierung der konventionellen und integrierten Szenarien verwendet. Beide Szenarien wurden verglichen und validiert. Die Fallstudie betrachtet mehrere Produkte sowie ein schwer zu planendes flowshop- System. Die Ergebnisse zeigen, dass die Gesamtkosten, einschließlich der Einrichtungs-, Lager- und Transportkosten, minimiert werden können, wenn das synchronisierte System angewendet wird.The main cost factors within a supply chain can be put into the categories of production, transportation, and inventory costs. The composition of these operational costs relative to total costs varies largely by industry. However, production cost is the largest of all in almost all the industries, followed by transportation and inventory costs. Optimizing one of these categories without consideration of the others may increase the total cost and reduce the overall performance. This dissertation deals with the production distribution problem of developing synchronized strategies to improve the supply chain performance and to minimize the total cost. A real case study is investigated. This real-life case study is a powder detergent plant located in Libya. There are two main scenarios evaluated. The first scenario is the conventional plan, where the manufacturer dominates. This means the manufacturer finds his own optimum job-scheduling plan, and the distributor tries to find the optimum plan according to it. This will increase the distribution cost. The second scenario involves synchronizing the production, inventory and transportation schedules. A Java program and SimAl (job-schedulingsoftware) were constructed for modelling conventional and integrated scenarios. The two scenarios were compared and validated. The case study considered multiple products and a flowshop system which is difficult to schedule. The results show that the total costs, including setup, inventory and transportation, can be minimized when the synchronized system is applied

New Solution Approaches for Scheduling Problems in Production and Logistics

The current cumulative PhD thesis consists of six papers published in/submitted to scientific journals. The focus of the thesis is to develop new solution approaches for scheduling problems encountering in manufacturing as well as in logistics. The thesis is divided into two parts: “ma-chine scheduling in production” and “scheduling problems in logistics” each of them consisting three papers. To have most comprehensive overview of the topic of machine scheduling, the first part of the thesis starts with two systematic review papers, which were conducted on tertiary level (i.e., re-viewing literature reviews). Both of these papers analyze a sample of around 130 literature re-views on machine scheduling problems. The first paper use a subjective quantitative approach to evaluate the sample, while the second papers uses content analysis which is an objective quanti-tative approach to extract meaningful information from massive data. Based on the analysis, main attributes of scheduling problems in production are identified and are classified into sever-al categories. Although the focus of both these papers are set to review scheduling problems in manufacturing, the results are not restricted to machine scheduling problem and the results can be extended to the second part of the thesis. General drawbacks of literature reviews are identi-fied and several suggestions for future researches are also provided in both papers. The third paper in the first part of the thesis presents the results of 105 new heuristic algorithms developed to minimize total flow time of a set of jobs in a flowshop manufacturing environ-ment. The computational experiments confirm that the best heuristic proposed in this paper im-proves the average error of best existing algorithm by around 25 percent. The first paper in second part is focused on minimizing number of electric tow-trains responsi-ble to deliver spare parts from warehouse to the production lines. Together with minimizing number of these electric vehicles the paper is also focused to maximize the work load balance among the drivers of the vehicles. For this problem, after analyzing the complexity of the prob-lem, an opening heuristic, a mixed integer linear programing (MILP) model and a taboo-search neighborhood search approach are proposed. Several managerial insights, such as the effect of battery capacity on the number of required vehicles, are also discussed. The second paper of the second part addresses the problem of preparing unit loaded devices (ULDs) at air cargos to be loaded latter on in planes. The objective of this problem is to mini-mize number of workers required in a way that all existing flight departure times are met and number of available places for building ULDs is not violated. For this problem, first, a MILP model is proposed and then it is boosted with a couple of heuristics which enabled the model to find near optimum solutions in a matter of 10 seconds. The paper also investigates the inherent tradeoff between labor and space utilization as well as the uncertainty about the volume of cargo to be processed. The last paper of the second part proposes an integrated model to improve both ergonomic and economic performance of manual order picking process by rotating pallets in the warehouse. For the problem under consideration in this paper, we first present and MILP model and then pro-pose a neighborhood search based on simulated annealing. The results of numerical experiment indicate that selectively rotating pallets may reduce both order picking time as well as the load on order picker, which leads to a quicker and less risky order picking process