Cardiomyopathy Causing Mutations Stabilize an Intermediate State of Thin Filaments

This is the author accepted manuscript. The final version is available from the publisher via the DOI in this recordWhen solving constrained multi-objective optimization problems, an important issue is how to balance convergence, diversity and feasibility simultaneously. To address this issue, this paper proposes a parameter-free constraint handling technique, a two-archive evolutionary algorithm, for constrained multi-objective optimization. It maintains two collaborative archives simultaneously: one, denoted as the convergence-oriented archive (CA), is the driving force to push the population toward the Pareto front; the other one, denoted as the diversity-oriented archive (DA), mainly tends to maintain the population diversity. In particular, to complement the behavior of the CA and provide as much diversified information as possible, the DA aims at exploring areas under-exploited by the CA including the infeasible regions. To leverage the complementary effects of both archives, we develop a restricted mating selection mechanism that adaptively chooses appropriate mating parents from them according to their evolution status. Comprehensive experiments on a series of benchmark problems and a real-world case study fully demonstrate the competitiveness of our proposed algorithm, in comparison to five state-of-the-art constrained evolutionary multi-objective optimizers.Royal Society (Government)Ministry of Science and Technology of ChinaScience and Technology Innovation Committee Foundation of ShenzhenShenzhen Peacock PlanEngineering and Physical Sciences Research Council (EPSRC

Multiobjective optimization of electromagnetic structures based on self-organizing migration

Práce se zabývá popisem nového stochastického vícekriteriálního optimalizačního algoritmu MOSOMA (Multiobjective Self-Organizing Migrating Algorithm). Je zde ukázáno, že algoritmus je schopen řešit nejrůznější typy optimalizačních úloh (s jakýmkoli počtem kritérií, s i bez omezujících podmínek, se spojitým i diskrétním stavovým prostorem). Výsledky algoritmu jsou srovnány s dalšími běžně používanými metodami pro vícekriteriální optimalizaci na velké sadě testovacích úloh. Uvedli jsme novou techniku pro výpočet metriky rozprostření (spread) založené na hledání minimální kostry grafu (Minimum Spanning Tree) pro problémy mající více než dvě kritéria. Doporučené hodnoty pro parametry řídící běh algoritmu byly určeny na základě výsledků jejich citlivostní analýzy. Algoritmus MOSOMA je dále úspěšně použit pro řešení různých návrhových úloh z oblasti elektromagnetismu (návrh Yagi-Uda antény a dielektrických filtrů, adaptivní řízení vyzařovaného svazku v časové oblasti…).This thesis describes a novel stochastic multi-objective optimization algorithm called MOSOMA (Multi-Objective Self-Organizing Migrating Algorithm). It is shown that MOSOMA is able to solve various types of multi-objective optimization problems (with any number of objectives, unconstrained or constrained problems, with continuous or discrete decision space). The efficiency of MOSOMA is compared with other commonly used optimization techniques on a large suite of test problems. The new procedure based on finding of minimum spanning tree for computing the spread metric for problems with more than two objectives is proposed. Recommended values of parameters controlling the run of MOSOMA are derived according to their sensitivity analysis. The ability of MOSOMA to solve real-life problems from electromagnetics is shown in a few examples (Yagi-Uda and dielectric filters design, adaptive beam forming in time domain…).

Multi agent collaborative search based on Tchebycheff decomposition

This paper presents a novel formulation of Multi Agent Collaborative Search, for multi-objective optimization, based on Tchebycheff decomposition. A population of agents combines heuristics that aim at exploring the search space both globally (social moves) and in a neighborhood of each agent (individualistic moves). In this novel formulation the selection process is based on a combination of Tchebycheff scalarization and Pareto dominance. Furthermore, while in the previous implementation, social actions were applied to the whole population of agents and individualistic actions only to an elite sub-population, in this novel formulation this mechanism is inverted. The novel agent-based algorithm is tested at first on a standard benchmark of difficult problems and then on two specific problems in space trajectory design. Its performance is compared against a number of state-of-the-art multi objective optimization algorithms. The results demonstrate that this novel agent-based search has better performance with respect to its predecessor in a number of cases and converges better than the other state-of-the-art algorithms with a better spreading of the solutions

Hybrid behavioural-based multi-objective space trajectory optimization

In this chapter we present a hybridization of a stochastic based search approach for multi-objective optimization with a deterministic domain decomposition of the solution space. Prior to the presentation of the algorithm we introduce a general formulation of the optimization problem that is suitable to describe both single and multi-objective problems. The stochastic approach, based on behaviorism, combinedwith the decomposition of the solutions pace was tested on a set of standard multi-objective optimization problems and on a simple but representative case of space trajectory design

A novel multi-objective evolutionary algorithm based on space partitioning

To design an e ective multi-objective optimization evolutionary algorithms (MOEA), we need to address the following issues: 1) the sensitivity to the shape of true Pareto front (PF) on decomposition-based MOEAs; 2) the loss of diversity due to paying so much attention to the convergence on domination-based MOEAs; 3) the curse of dimensionality for many-objective optimization problems on grid-based MOEAs. This paper proposes an MOEA based on space partitioning (MOEA-SP) to address the above issues. In MOEA-SP, subspaces, partitioned by a k-dimensional tree (kd-tree), are sorted according to a bi-indicator criterion de ned in this paper. Subspace-oriented and Max-Min selection methods are introduced to increase selection pressure and maintain diversity, respectively. Experimental studies show that MOEA-SP outperforms several compared algorithms on a set of benchmarks