1,400 research outputs found

    Cognitive Training With Healthy Older Adults: Investigating the Effectiveness of the Brain Age Software for Nintendo DS

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    An increasing number of empirical studies have demonstrated the effectiveness of cognitive training (CT) with healthy, cognitively intact older adults. Less is known regarding the effectiveness of commercially available “brain training” programs. The current study investigated the impact of daily CT presented via the Brain Age® software for Nintendo DS on neurocognitive abilities in a sample of healthy, community-dwelling older adults. Over the six-week study, participants in the CT group completed training activities and were compared to an active control group who played card games on the Nintendo DS. At pre-test and post-test, a wide range of empirically validated neuropsychological outcome measures was administered to examine the proximal and distal transfer effects of training. Although within normal range, the average MMSE score was significantly higher in the control group at pre-test; no other baseline differences in demographics or performance on primary neuropsychological outcome measures were observed. In the CT group, estimated “brain age” decreased and performance on daily training tasks significantly improved over the six-week study period. Importantly however, performance improved from pre-test to post-test on measures of everyday verbal memory, visual working memory, and math fluency in both the CT and active control groups. Participants in the CT group rated usage of the Brain Age software as significantly more mentally challenging and endorsed greater subjective memory improvement at post-test than participants in the control group. These findings demonstrate that both CT and cognitive stimulation protocols produced transfer effects in the current study. That is, Brain Age software use led to enhanced cognitive performance over time, but it did not do in a manner that exceeded the effects achieved by general cognitive stimulation. Enhanced working memory in the CT group and executive attention in the control group are discussed as possible explanation for improved performance on the outcome measures

    Drugs, games, and devices for enhancing cognition: implications for work and society

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    As work environments change, the demands on working people change. Cognitive abilities in particular are becoming progressively more important for work performance and successful competition in a global environment. However, work-related stress, performance over long hours, lack of sleep, shift work, and jet lag affect cognitive functions. Therefore, an increasing number of healthy people are reported to use cognitive-enhancing drugs, as well as other interventions, such as noninvasive brain stimulation, to maintain or improve work performance. This review summarizes research on pharmacological and technical methods as well as cognitive training, including game apps for the brain, in healthy people. In neuropsychiatric disorders, impairments in cognitive functions can drastically reduce the chances of returning to work; therefore, this review also summarizes findings from pharmacological and cognitive-training studies in neuropsychiatric disorders.All cited psychopharmacological work from Professor Sahakian laboratory was funded by a Wellcome Trust Grant (089589/Z/09/Z) awarded to T.W. Robbins, B.J. Everitt, A.C. Roberts, J.W. Dalley, and B.J. Sahakian, and it was conducted at the Behavioural and Clinical Neuroscience Institute, which is supported by a joint award from the Medical Research Council and Wellcome Trust (G00001354). ABB was supported by a grant from the The Wallitt Foundation.This is the author accepted manuscript. The final version is available from Wiley via http://dx.doi.org/10.1111/nyas.1304

    Interventional programmes to improve cognition during healthy and pathological ageing: Cortical modulations and evidence for brain plasticity

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    Available online 06 March 2018A growing body of evidence suggests that healthy elderly individuals and patients with Alzheimer’s disease retain an important potential for neuroplasticity. This review summarizes studies investigating the modulation of neural activity and structural brain integrity in response to interventions involving cognitive training, physical exercise and non-invasive brain stimulation in healthy elderly and cognitively impaired subjects (including patients with mild cognitive impairment (MCI) and Alzheimer’s disease). Moreover, given the clinical relevance of neuroplasticity, we discuss how evidence for neuroplasticity can be inferred from the functional and structural brain changes observed after implementing these interventions. We emphasize that multimodal programmes, which combine several types of interventions, improve cognitive function to a greater extent than programmes that use a single interventional approach. We suggest specific methods for weighting the relative importance of cognitive training, physical exercise and non-invasive brain stimulation according to the functional and structural state of the brain of the targeted subject to maximize the cognitive improvements induced by multimodal programmes.This study was funded by the European Commission Marie-Skłodowska Curie Actions, Individual Fellowships; 655423-NIBSAD, Italian Ministry of HealthGR-2011-02349998, and Galician government (Postdoctoral Grants Plan I2C 2011-2015)

    The Gray Matter project: modificating lifestyles to prevent dementia

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    As dementia aetiology is based on different bio-psychosocial factors, prevention strategies for dementia have recently focused on multi-domain interventions of individuals at risk and/or with a normative cognitive level, encouraging the lifestyle change through combined programs of physical activity, cognitive training, nutrition education and social activities (in chapter 1, a narrative review of these studies is presented). Most of the multidomain intervention aimed on the prevention of cognitive disease are carried on with elderly patients with a mild cognitive decline or on at-risk adult categories. 5 Caregivers of patients with dementia are considered as an at-risk category. The majority of them (86%) are represented by family members (prominently women) who are also defined as “informal caregivers”. They fulfil their caringgiving role from 7 to 11 h a day on average, up to 10-15 h when clinical conditions worsen 10. Informal caregivers have to cope with physical, psychological and social stressors that affect their health conditions and quality of life negatively (Eleuteri et al., 2016). The burdens of caregiving include many things that have been shown to increase the risk of cognitive decline, including chronic stress, social isolation, depression, decreased physical activity, and a shift in eating habits toward more fast food and significantly more weight compared with controls (Vitaliano et al., 1996). This could be connected with the important role that sleep plays between stress and metabolic health (Geiker et al., 2018). Being a caregiver has been found to be a factor affecting negatively sleep quality (Brummett et al., 2006). Interventions to promote positive lifestyles are, therefore, important in order to improve the caregivers’ general health and, specifically, to prevent the cognitive decline. In the second chapter, an article recently published specifies the importance of multimodal interventions in ameliorating caregivers’ health, since complex moderation and mediation effects exist between the different areas involved in the AD risk reduction. The third chapter will, finally, describe the results of the Gray Matter Project, a multidomain pilot RCT, firstly carried out done in Cache County, Utah designed to promote positive changes in lifestyle (exercise, nutrition, cognitive stimulation, social engagement, stress management, and sleep quality), specifically for the purpose of reducing AD risk in family caregivers of elderly with dementia

    2nd Place Research Paper: Effects of Cognitive Interventions on the Cognition of Patients Diagnosed With Dementia

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    The aim of this literature review was to test the hypothesis: If a patient diagnosed with dementia participates in a cognitive intervention, then they will develop fewer cognitive deficits than a patient diagnosed with dementia who does not participate in a cognitive intervention. Recent literature was systematically searched using several databases. A total of 20 empirical articles were included in this review. Inclusion criteria consisted of a diagnosis of dementia for each participating patient. Each study includes an experimental group of patients who participated in a cognitive intervention and a control group of patients who did not participate in a cognitive intervention. Various types of cognitive interventions were tested during these studies. The cognitive abilities of all patients were tested prior to and at the conclusion of treatment. The cognitive changes experienced by patients who participated in the cognitive interventions were compared to the cognitive changes experienced by patients who did not participate the cognitive interventions. The findings of these studies varied in their relationship to the thesis hypothesis. Ten of these studies showed results that supported the thesis hypothesis, 7 studies refuted the thesis hypothesis, and 3 studies showed findings that both supported and refuted the thesis hypothesis. The variance of results can be explained by the differing cognitive functions of focus of each cognitive intervention. Some of these interventions proved to have greater benefits on the cognitive abilities of patients diagnosed with dementia than others

    Interventions for Persons with Mild Cognitive Impairment (MCI) An Evidence-Based Practice Project

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    This Evidence-Based Practice (EBP) project addressed the following question: What occupational therapy and multidisciplinary/interprofessional interventions are most effective for addressing mild cognitive impairment (MCI) to improve occupational performance, functional cognition, participation, well-being, quality of life, and caregiver burden

    Exploring the impact of Cognitive Health Enhancing Behaviours, Subjective Cognitive Complaints, Fear of Dementia and Generalised Anxiety on Cognitive Function

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    There has been much interest recently in health behaviours that might reduce the risk of neurodegenerative illnesses that cause dementia. Examples of behaviours that potentially enhance (neuro)cognitive health include exercising, maintaining social connections, cognitive activity, and diet. This thesis explores how anxiety mediates the relationship between cognitive health enhancing behaviours and cognitive functioning in healthy adults. Part I is a systematic literature review examining the impact of psychosocial, cognitive training, and multidomain interventions on cognitive functioning. In total, 31 randomised controlled trials (RCTs) were included in this review. Part II presents a secondary analysis of data collected from a charity called Food for the Brain (FFB). Structural Equation Modelling (SEM) was used to analyse whether different types of anxiety mediate the relationship between cognitive health enhancing behaviours and cognitive functioning. Exploratory analysis of longitudinal data collected at six, 12 and 24 months after baseline, investigated predictors of change in cognitive health enhancing behaviours over time. Part III is a critical appraisal that reflects on my experience of co-production and completing the systematic review for the APPLE-Tree project, methodological problems with the measures in the empirical study and the role that clinical psychology has in public health
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