Mitigation of artifacts due to isolated acoustic heterogeneities in photoacoustic computed tomography using a variable data truncation-based reconstruction method

Photoacoustic computed tomography (PACT) is an emerging computed imaging modality that exploits optical contrast and ultrasonic detection principles to form images of the absorbed optical energy density within tissue. If the object possesses spatially variant acoustic properties that are unaccounted for by the reconstruction method, the estimated image can contain distortions. While reconstruction methods have recently been developed to compensate for this effect, they generally require the object's acoustic properties to be known a priori. To circumvent the need for detailed information regarding an object's acoustic properties, we previously proposed a half-time reconstruction method for PACT. A half-time reconstruction method estimates the PACT image from a data set that has been temporally truncated to exclude the data components that have been strongly aberrated. However, this method can be improved upon when the approximate sizes and locations of isolated heterogeneous structures, such as bones or gas pockets, are known. To address this, we investigate PACT reconstruction methods that are based on a variable data truncation (VDT) approach. The VDT approach represents a generalization of the half-time approach, in which the degree of temporal truncation for each measurement is determined by the distance between the corresponding ultrasonic transducer location and the nearest known bone or gas void location. Computer-simulated and experimental data are employed to demonstrate the effectiveness of the approach in mitigating artifacts due to acoustic heterogeneities

A Hybrid Segmentation and D-bar Method for Electrical Impedance Tomography

The Regularized D-bar method for Electrical Impedance Tomography provides a rigorous mathematical approach for solving the full nonlinear inverse problem directly, i.e. without iterations. It is based on a low-pass filtering in the (nonlinear) frequency domain. However, the resulting D-bar reconstructions are inherently smoothed leading to a loss of edge distinction. In this paper, a novel approach that combines the rigor of the D-bar approach with the edge-preserving nature of Total Variation regularization is presented. The method also includes a data-driven contrast adjustment technique guided by the key functions (CGO solutions) of the D-bar method. The new TV-Enhanced D-bar Method produces reconstructions with sharper edges and improved contrast while still solving the full nonlinear problem. This is achieved by using the TV-induced edges to increase the truncation radius of the scattering data in the nonlinear frequency domain thereby increasing the radius of the low pass filter. The algorithm is tested on numerically simulated noisy EIT data and demonstrates significant improvements in edge preservation and contrast which can be highly valuable for absolute EIT imaging

Estimating the Spectrum in Computed Tomography Via Kullback–Leibler Divergence Constrained Optimization

Purpose We study the problem of spectrum estimation from transmission data of a known phantom. The goal is to reconstruct an x‐ray spectrum that can accurately model the x‐ray transmission curves and reflects a realistic shape of the typical energy spectra of the CT system. Methods Spectrum estimation is posed as an optimization problem with x‐ray spectrum as unknown variables, and a Kullback–Leibler (KL)‐divergence constraint is employed to incorporate prior knowledge of the spectrum and enhance numerical stability of the estimation process. The formulated constrained optimization problem is convex and can be solved efficiently by use of the exponentiated‐gradient (EG) algorithm. We demonstrate the effectiveness of the proposed approach on the simulated and experimental data. The comparison to the expectation–maximization (EM) method is also discussed. Results In simulations, the proposed algorithm is seen to yield x‐ray spectra that closely match the ground truth and represent the attenuation process of x‐ray photons in materials, both included and not included in the estimation process. In experiments, the calculated transmission curve is in good agreement with the measured transmission curve, and the estimated spectra exhibits physically realistic looking shapes. The results further show the comparable performance between the proposed optimization‐based approach and EM. Conclusions Our formulation of a constrained optimization provides an interpretable and flexible framework for spectrum estimation. Moreover, a KL‐divergence constraint can include a prior spectrum and appears to capture important features of x‐ray spectrum, allowing accurate and robust estimation of x‐ray spectrum in CT imaging

Sparsity prior for electrical impedance tomography with partial data

This paper focuses on prior information for improved sparsity reconstruction in electrical impedance tomography with partial data, i.e. data measured only on subsets of the boundary. Sparsity is enforced using an $\ell_1$ norm of the basis coefficients as the penalty term in a Tikhonov functional, and prior information is incorporated by applying a spatially distributed regularization parameter. The resulting optimization problem allows great flexibility with respect to the choice of measurement boundaries and incorporation of prior knowledge. The problem is solved using a generalized conditional gradient method applying soft thresholding. Numerical examples show that the addition of prior information in the proposed algorithm gives vastly improved reconstructions even for the partial data problem. The method is in addition compared to a total variation approach.Comment: 17 pages, 12 figure