Advanced receivers and waveforms for UAV/Aircraft aeronautical communications

Nowadays, several studies are launched for the design of reliable and safe communications systems that introduce Unmanned Aerial Vehicle (UAV), this paves the way for UAV communication systems to play an important role in a lot of applications for non-segregated military and civil airspaces. Until today, rules for integrating commercial UAVs in airspace still need to be defined, the design of secure, highly reliable and cost effective communications systems still a challenging task. This thesis is part of this communication context. Motivated by the rapid growth of UAV quantities and by the new generations of UAVs controlled by satellite, the thesis aims to study the various possible UAV links which connect UAV/aircraft to other communication system components (satellite, terrestrial networks, etc.). Three main links are considered: the Forward link, the Return link and the Mission link. Due to spectrum scarcity and higher concentration in aircraft density, spectral efficiency becomes a crucial parameter for largescale deployment of UAVs. In order to set up a spectrally efficient UAV communication system, a good understanding of transmission channel for each link is indispensable, as well as a judicious choice of the waveform. This thesis begins to study propagation channels for each link: a mutipath channels through radio Line-of-Sight (LOS) links, in a context of using Meduim Altitude Long drones Endurance (MALE) UAVs. The objective of this thesis is to maximize the solutions and the algorithms used for signal reception such as channel estimation and channel equalization. These algorithms will be used to estimate and to equalize the existing muti-path propagation channels. Furthermore, the proposed methods depend on the choosen waveform. Because of the presence of satellite link, in this thesis, we consider two low-papr linear waveforms: classical Single-Carrier (SC) waveform and Extented Weighted Single-Carrier Orthogonal Frequency-Division Multiplexing (EW-SC-OFDM) waveform. channel estimation and channel equalization are performed in the time-domain (SC) or in the frequency-domain (EW-SC-OFDM). UAV architecture envisages the implantation of two antennas placed at wings. These two antennas can be used to increase diversity gain (channel matrix gain). In order to reduce channel equalization complexity, the EWSC- OFDM waveform is proposed and studied in a muti-antennas context, also for the purpose of enhancing UAV endurance and also increasing spectral efficiency, a new modulation technique is considered: Spatial Modulation (SM). In SM, transmit antennas are activated in an alternating manner. The use of EW-SC-OFDM waveform combined to SM technique allows us to propose new modified structures which exploit exces bandwidth to improve antenna bit protection and thus enhancing system performances

Air Traffic Management Abbreviation Compendium

As in all fields of work, an unmanageable number of abbreviations are used today in aviation for terms, definitions, commands, standards and technical descriptions. This applies in general to the areas of aeronautical communication, navigation and surveillance, cockpit and air traffic control working positions, passenger and cargo transport, and all other areas of flight planning, organization and guidance. In addition, many abbreviations are used more than once or have different meanings in different languages. In order to obtain an overview of the most common abbreviations used in air traffic management, organizations like EUROCONTROL, FAA, DWD and DLR have published lists of abbreviations in the past, which have also been enclosed in this document. In addition, abbreviations from some larger international projects related to aviation have been included to provide users with a directory as complete as possible. This means that the second edition of the Air Traffic Management Abbreviation Compendium includes now around 16,500 abbreviations and acronyms from the field of aviation

The use of computer-aided drug design in small molecule drug discovery

Drug discovery is one of the most challenging research fields that contributes to the birth of novel drugs for therapeutic use. Due to the complexity and intricate nature of the research, lengthy processes are involved in identifying potential hit molecules for a therapeutic target. To shorten the time required to reach the hit-to-lead stage, computer-aided drug design (CADD) has been used to expedite the process and reduce laboratory expenses. Common strategies used within CADD involve structure-based drug design (SBDD) and ligand-based drug design (LBDD). Both strategies were used extensively in two projects showing the complementarity of each strategy throughout the process. In this work, two separate drug discovery projects are detailed: Design, synthesis and molecular docking study of novel tetrahydrocurcumin analogues as potential sarcoplasmic-endoplasmic reticulum calcium ATPases (SERCA) inhibitors – details the identification, synthesis and testing of potential hit candidate(s) targeting SERCA by using SBDD Filamenting temperature-sensitive mutant Z (FtsZ) as therapeutic target in ligand-based drug design – details the identification, synthesis and testing of potential hit molecule(s) targeting FtsZ In the first project, homology modelling and virtual compound library screening were utilised as the SBDD methods to identify potential hit molecules for testing in P-type calcium ATPases such as SERCA. Preliminary results have found compound 20, an analogue of tetrahydrocurcumin, to show some SERCA inhibitory effect at 300µM based on a SERCA-specific calcium signalling assay performed via fluorometric imaging plate reader. Molecular docking study has also reflected this outcome with desirable ligand-protein binding energies found for 20 when compared with other tested ligands. Pharmacophore screening was used as the main LBDD method in the second project to identify probable hit candidates targeting FtsZ. Potential ligands were synthesised, and tested for antibacterial effect in Bacillus Subtilis strain 168 (Bs168) and Streptococcus pneumoniae strain R6 (SpnR6) cells. One of the tetrahydrocurcumin analogues, compound 4, was found to have minimum inhibitory concentration (MIC) ≤ 10 µM in Bs168 cells and ≤ 2 µM in spnR6 cells. The IC50 values for 4 were 9.1 ± 0.01 µM and 1 ± 0.01 µM in Bs168 and SpnR6 cells respectively. The MIC of 4 was found to be very similar to the MIC of compound 1, a known hit compound targeting against Bs168 cells. On the other hand, the MIC of 4 was lower than the MIC (> 64 µg/mL) of a well-known FtsZ inhibitor, PC190723, against S. pneumoniae. Subsequent molecular docking analyses were completed to evaluate the ligand-protein binding energies to correlate against the testing results. Both compounds 20 and 4 possess some structural similarities and differences that may confer their different effects in these protein targets, which render both with potentials to become the next lead molecules for future development