11,653 research outputs found
Tensor Regression with Applications in Neuroimaging Data Analysis
Classical regression methods treat covariates as a vector and estimate a
corresponding vector of regression coefficients. Modern applications in medical
imaging generate covariates of more complex form such as multidimensional
arrays (tensors). Traditional statistical and computational methods are proving
insufficient for analysis of these high-throughput data due to their ultrahigh
dimensionality as well as complex structure. In this article, we propose a new
family of tensor regression models that efficiently exploit the special
structure of tensor covariates. Under this framework, ultrahigh dimensionality
is reduced to a manageable level, resulting in efficient estimation and
prediction. A fast and highly scalable estimation algorithm is proposed for
maximum likelihood estimation and its associated asymptotic properties are
studied. Effectiveness of the new methods is demonstrated on both synthetic and
real MRI imaging data.Comment: 27 pages, 4 figure
White matter differences between healthy young ApoE4 carriers and non-carriers identified with tractography and support vector machines.
The apolipoprotein E4 (ApoE4) is an established risk factor for Alzheimer's disease (AD). Previous work has shown that this allele is associated with functional (fMRI) changes as well structural grey matter (GM) changes in healthy young, middle-aged and older subjects. Here, we assess the diffusion characteristics and the white matter (WM) tracts of healthy young (20-38 years) ApoE4 carriers and non-carriers. No significant differences in diffusion indices were found between young carriers (ApoE4+) and non-carriers (ApoE4-). There were also no significant differences between the groups in terms of normalised GM or WM volume. A feature selection algorithm (ReliefF) was used to select the most salient voxels from the diffusion data for subsequent classification with support vector machines (SVMs). SVMs were capable of classifying ApoE4 carrier and non-carrier groups with an extremely high level of accuracy. The top 500 voxels selected by ReliefF were then used as seeds for tractography which identified a WM network that included regions of the parietal lobe, the cingulum bundle and the dorsolateral frontal lobe. There was a non-significant decrease in volume of this WM network in the ApoE4 carrier group. Our results indicate that there are subtle WM differences between healthy young ApoE4 carriers and non-carriers and that the WM network identified may be particularly vulnerable to further degeneration in ApoE4 carriers as they enter middle and old age
Computer-Aided Diagnosis in Neuroimaging
This chapter is intended to provide an overview to the most used methods for computer-aided diagnosis in neuroimaging and its application to neurodegenerative diseases. The fundamental preprocessing steps, and how they are applied to different image modalities, will be thoroughly presented. We introduce a number of widely used neuroimaging analysis algorithms, together with a wide overview on the recent advances in brain imaging processing. Finally, we provide a general conclusion on the state of the art in brain imaging processing and possible future developments
Quicksilver: Fast Predictive Image Registration - a Deep Learning Approach
This paper introduces Quicksilver, a fast deformable image registration
method. Quicksilver registration for image-pairs works by patch-wise prediction
of a deformation model based directly on image appearance. A deep
encoder-decoder network is used as the prediction model. While the prediction
strategy is general, we focus on predictions for the Large Deformation
Diffeomorphic Metric Mapping (LDDMM) model. Specifically, we predict the
momentum-parameterization of LDDMM, which facilitates a patch-wise prediction
strategy while maintaining the theoretical properties of LDDMM, such as
guaranteed diffeomorphic mappings for sufficiently strong regularization. We
also provide a probabilistic version of our prediction network which can be
sampled during the testing time to calculate uncertainties in the predicted
deformations. Finally, we introduce a new correction network which greatly
increases the prediction accuracy of an already existing prediction network. We
show experimental results for uni-modal atlas-to-image as well as uni- / multi-
modal image-to-image registrations. These experiments demonstrate that our
method accurately predicts registrations obtained by numerical optimization, is
very fast, achieves state-of-the-art registration results on four standard
validation datasets, and can jointly learn an image similarity measure.
Quicksilver is freely available as an open-source software.Comment: Add new discussion
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