10,360 research outputs found

    Categorizing Flight Paths using Data Visualization and Clustering Methodologies

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    This work leverages the U.S. Federal Aviation Administration's Traffic Flow Management System dataset and DV8, a recently developed tool for highly interactive visualization of air traffic data, to develop clustering algorithms for categorizing air traffic by their varying flight paths. Two clustering methodologies, a spatial-based geographic distance model, and a vector-based cosine similarity model, are demonstrated and compared for their clustering effectiveness. Examples of their applications reveal successful, realistic clustering based on automated clustering result determination and human-in-the-loop processes, with geographic distance algorithms performing better for enroute portions of flight paths and cosine similarity algorithms performing better for near-terminal operations, such as arrival paths. A point extraction technique is applied to improve computation efficiency.Comment: Published in the 9th International Conference on Research in Air Transportation (ICRAT'20): https://www.icrat.org/previous-conferences/9th-international-conference/papers

    A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys

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    Defining cellular and molecular identities within the kidney is necessary to understand its organization and function in health and disease. Here we demonstrate a reproducible method with minimal artifacts for single-nucleus Droplet-based RNA sequencing (snDrop-Seq) that we use to resolve thirty distinct cell populations in human adult kidney. We define molecular transition states along more than ten nephron segments spanning two major kidney regions. We further delineate cell type-specific expression of genes associated with chronic kidney disease, diabetes and hypertension, providing insight into possible targeted therapies. This includes expression of a hypertension-associated mechano-sensory ion channel in mesangial cells, and identification of proximal tubule cell populations defined by pathogenic expression signatures. Our fully optimized, quality-controlled transcriptomic profiling pipeline constitutes a tool for the generation of healthy and diseased molecular atlases applicable to clinical samples

    Inferring transportation modes from GPS trajectories using a convolutional neural network

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    Identifying the distribution of users' transportation modes is an essential part of travel demand analysis and transportation planning. With the advent of ubiquitous GPS-enabled devices (e.g., a smartphone), a cost-effective approach for inferring commuters' mobility mode(s) is to leverage their GPS trajectories. A majority of studies have proposed mode inference models based on hand-crafted features and traditional machine learning algorithms. However, manual features engender some major drawbacks including vulnerability to traffic and environmental conditions as well as possessing human's bias in creating efficient features. One way to overcome these issues is by utilizing Convolutional Neural Network (CNN) schemes that are capable of automatically driving high-level features from the raw input. Accordingly, in this paper, we take advantage of CNN architectures so as to predict travel modes based on only raw GPS trajectories, where the modes are labeled as walk, bike, bus, driving, and train. Our key contribution is designing the layout of the CNN's input layer in such a way that not only is adaptable with the CNN schemes but represents fundamental motion characteristics of a moving object including speed, acceleration, jerk, and bearing rate. Furthermore, we ameliorate the quality of GPS logs through several data preprocessing steps. Using the clean input layer, a variety of CNN configurations are evaluated to achieve the best CNN architecture. The highest accuracy of 84.8% has been achieved through the ensemble of the best CNN configuration. In this research, we contrast our methodology with traditional machine learning algorithms as well as the seminal and most related studies to demonstrate the superiority of our framework.Comment: 12 pages, 3 figures, 7 tables, Transportation Research Part C: Emerging Technologie
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