An Ontology-Based Artificial Intelligence Model for Medicine Side-Effect Prediction: Taking Traditional Chinese Medicine as An Example

In this work, an ontology-based model for AI-assisted medicine side-effect (SE) prediction is developed, where three main components, including the drug model, the treatment model, and the AI-assisted prediction model, of proposed model are presented. To validate the proposed model, an ANN structure is established and trained by two hundred and forty-two TCM prescriptions. These data are gathered and classified from the most famous ancient TCM book and more than one thousand SE reports, in which two ontology-based attributions, hot and cold, are introduced to evaluate whether the prescription will cause SE or not. The results preliminarily reveal that it is a relationship between the ontology-based attributions and the corresponding predicted indicator that can be learnt by AI for predicting the SE, which suggests the proposed model has a potential in AI-assisted SE prediction. However, it should be noted that, the proposed model highly depends on the sufficient clinic data, and hereby, much deeper exploration is important for enhancing the accuracy of the prediction

Biopiracy <i>versus </i>one-world medicine – from colonial relicts to global collaborative concepts

Background: Practices of biopiracy to use genetic resources and indigenous knowledge by Western companies without benefit-sharing of those, who generated the traditional knowledge, can be understood as form of neocolonialism.Hypothesis: : The One-World Medicine concept attempts to merge the best of traditional medicine from developing countries and conventional Western medicine for the sake of patients around the globe.Study design: Based on literature searches in several databases, a concept paper has been written. Legislative initiatives of the United Nations culminated in the Nagoya protocol aim to protect traditional knowledge and regulate benefit-sharing with indigenous communities. The European community adopted the Nagoya protocol, and the corresponding regulations will be implemented into national legislation among the member states. Despite pleasing progress, infrastructural problems of the health care systems in developing countries still remain. Current approaches to secure primary health care offer only fragmentary solutions at best. Conventional medicine from industrialized countries cannot be afforded by the impoverished population in the Third World. Confronted with exploding costs, even health systems in Western countries are endangered to burst. Complementary and alternative medicine (CAM) is popular among the general public in industrialized countries, although the efficacy is not sufficiently proven according to the standards of evidence-based medicine. CAM is often available without prescription as over-the-counter products with non-calculated risks concerning erroneous self-medication and safety/toxicity issues. The concept of integrative medicine attempts to combine holistic CAM approaches with evidence-based principles of conventional medicine.Conclusion: To realize the concept of One-World Medicine, a number of standards have to be set to assure safety, efficacy and applicability of traditional medicine, e.g. sustainable production and quality control of herbal products, performance of placebo-controlled, double-blind, randomized clinical trials, phytovigilance, as well as education of health professionals and patients

The Analysis of Existing Experience for the Ethnobotanical Information System

Ethnobotanical researches reflect the conventional learning of a region. Over the previous decade, medical plants which used for healing indigenous people has become a significant notion among the people and impacted improvement of scientific and ethnobotanical knowledge and investigations of eliminating health problems. A public database has been based on data assembled from various verifiable sources, including journals, travel records, and treatises on therapeutic plants, composed by explorers, botanists, doctors, researchers who went to the nations during the most recent three centuries. In addition, ethnobotanical data depicted in chronicled natural accumulations and in Ancient and Medieval writings from the inquired district have been incorporated into the database. The databases have to be sufficiently adaptable to illustrate a valuable tool for analysts who need to store and analyze present and past ethnobotanical data from the researched location. The ethnobotanical researches are improved in Azerbaijan day by day. The database is used for informing people about some national plants which are growing in the different region of Azerbaijan. The ethnobotanical databases from different countries are analyzed in this article.There are used some special methods for comparing the differences among these databases as data mining and text mining. As a first step the suitable databases are gathered for our investigation, then are defined the best information systems that are used in many countries\u27 biologists and scientists and the end is observed advantages and disadvantages of all existing ethnobotanical databases which we researched. The features of information systems are evaluated. The results demonstrated each of databases has its very own quality, but none has turned a standard form for universal research. The reason is very basic: none of these databases enable specialists to include their own information. There is also illustrated sample structure, main tables and key components of the ethnobotanical database.The obtained results, while a few ethnobotanical databases existing, none are satisfactory answers for worldwide work, and none enable analysts to include their very own information. There is a need brought together all essential properties of existing databases, and creating a free database that encourages ethnobotanical research. Due to the rise and quick improvement in the field of data advances, it has now turned out to be conceivable to digitize, oversee and make ethnobotanical information accessible to a more extensive gathering of people

Exploring the Potential of Large Language models in Traditional Korean Medicine: A Foundation Model Approach to Culturally-Adapted Healthcare

Introduction: Traditional Korean medicine (TKM) emphasizes individualized diagnosis and treatment, making AI modeling difficult due to limited data and implicit processes. GPT-3.5 and GPT-4, large language models, have shown impressive medical knowledge despite lacking medicine-specific training. This study aimed to assess the capabilities of GPT-3.5 and GPT-4 for TKM using the Korean National Licensing Examination for Korean Medicine Doctors. Methods: GPT-3.5 (February 2023) and GPT-4 (March 2023) models answered 340 questions from the 2022 examination across 12 subjects. Each question was independently evaluated five times in an initialized session. Results: GPT-3.5 and GPT-4 achieved 42.06% and 57.29% accuracy, respectively, with GPT-4 nearing passing performance. There were significant differences in accuracy by subjects, with 83.75% accuracy for neuropsychiatry compared to 28.75% for internal medicine (2). Both models showed high accuracy in recall-based and diagnosis-based questions but struggled with intervention-based ones. The accuracy for questions that require TKM-specialized knowledge was relatively lower than the accuracy for questions that do not GPT-4 showed high accuracy for table-based questions, and both models demonstrated consistent responses. A positive correlation between consistency and accuracy was observed. Conclusion: Models in this study showed near-passing performance in decision-making for TKM without domain-specific training. However, limits were also observed that were believed to be caused by culturally-biased learning. Our study suggests that foundation models have potential in culturally-adapted medicine, specifically TKM, for clinical assistance, medical education, and medical research.Comment: 31 pages, 6 figure